Kaitlin M. Bratlie
Iowa State University
Self-healing hydrogelsAnalytical chemistryBiophysicsPhenotypeBiomedical engineeringAdsorptionInfrared spectroscopyCatalysisNanotechnologyChemistryMaterials scienceBenzeneBiomaterialMacrophageDrug deliveryWound healingChemical engineeringTissue engineeringPlatinumCell biology
72Publications
22H-index
2,389Citations
Publications 68
Newest
#1Lida Zhu (Iowa State University)H-Index: 2
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
Abstract The pH of cutaneous wounds is dynamic and correlates with the stage of the wound healing process. The inflammation stage is acidic, granulation shifts to a progressively alkali pH, and the remodeling phase returns skin to its pre-injury pH. By taking the advantage of this pH difference, stage-specific wound treatments can be developed to respond to these environmental cues using pH sensitive hydrogels. To obtain tunable physical and chemical properties, chitosan was first methacrylated ...
20 CitationsSource
#1Dana Akilbekova (NU: Nazarbayev University)H-Index: 8
#2Anuraag Boddupalli (Iowa State University)H-Index: 4
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
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Recent studies have demonstrated the beneficial effect of low-power lasers and polarized light on wound healing, inflammation, and the treatment of rheumatologic and neurologic disorders. The overall effect of laser irradiation treatment is still controversial due to the lack of studies on the biochemical mechanisms and the optimal parameters for the incident light that should be chosen for particular applications. Here, we study how NIH/3T3 fibroblasts respond to irradiation with linearly polar...
1 CitationsSource
#1Lida Zhu (Iowa State University)H-Index: 2
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
Abstract Surfactants are commonly used drug carriers, however, there is a lack of understanding regarding the relationship between drug loading, drug release kinetics, and cell internalization with the physicochemical properties of the drug carriers, preventing rational design. The effects of altering hydrophobic and hydrophilic chain lengths on a poly[poly-(oxyethylene)-oxy-5-hydroxyisophthaloyl] (Ppeg) platform for delivering hydrophobic drugs was examined. The synthesized polymers were charac...
2 CitationsSource
#1Hannah C. Bygd (Iowa State University)H-Index: 7
#2Lilusi Ma (Iowa State University)H-Index: 2
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
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Abstract Liposomes are one of the most widely studied drug carriers due to their relative biocompatibility, lack of immune system stimulation, ability to be cell specific, and serve as a protective drug carrier. Due to several physicochemical properties such as size and charge, liposomes naturally target the phagocytic capabilities of macrophages. In the tumor microenvironment, macrophages strongly influence growth and progression, making them an appealing target for drug delivery. Using the nat...
6 CitationsSource
#1Lilusi Ma (Iowa State University)H-Index: 2
#2Hannah C. Bygd (Iowa State University)H-Index: 7
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
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The effects of surface modifications on liposomes using a library of arginine derivatives for improved drug delivery were examined. Both unmodified and modified liposomes were tested for their drug delivery properties and propensity for internalization by macrophages. All materials were characterized by dynamic light scattering (DLS) and zeta potential. The resulting liposomes were able to encapsulate doxorubicin with a loading efficiency greater than 90% and cumulative releases of less than 15%...
9 CitationsSource
#1Hannah C. Bygd (Iowa State University)H-Index: 7
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
Understanding macrophage responses to biomaterials is crucial to the success of implanted medical devices, tissue engineering scaffolds, and drug delivery vehicles. Cellular responses to materials may depend synergistically on multiple surface chemistries, due to the polyvalent nature of cell–ligand interactions. Previous work in our lab found that different surface functionalities of chemically modified alginate could sway macrophage phenotype toward either the pro-inflammatory or pro-angiogeni...
5 CitationsSource
#1Anuraag Boddupalli (Iowa State University)H-Index: 4
#2Lida Zhu (Iowa State University)H-Index: 2
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
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This review focuses on materials and methods used to induce phenotypic changes in macrophages and fibroblasts. Herein, we give a brief overview on how changes in macrophages and fibroblasts phenotypes are critical biomarkers for identification of implant acceptance, wound healing effectiveness, and are also essential for evaluating the regenerative capabilities of some hybrid strategies that involve the combination of natural and synthetic materials. The different types of cells present during t...
29 CitationsSource
Macrophage (MΦ) reprogramming has received significant attention in applications such as cancer therapeutics and tissue engineering where the host immune response to biomaterials is crucial in determining the success or failure of an implanted device. Polymeric systems can potentially be used to redirect infiltrating M1 MΦs toward a proangiogenic phenotype. This work exploits the concept of MΦ reprogramming in the engineering of materials for improving the longevity of tissue engineering scaffol...
20 CitationsSource
#1Arturo J. VegasH-Index: 25
#2Omid VeisehH-Index: 42
Last. Daniel G. AndersonH-Index: 119
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Nat. Biotechnol. 34, 345–352 (2016); published online 29 January 2016; corrected after print 18 April 2016 In the version of this article initially published, one author, Adam C. Graham, his affiliation, and his contribution were omitted. In addition, two acknowledgments, to W. Salmon and J. Wyckoff, were omitted.
10 CitationsSource
#1Hai Tran (Iowa State University)H-Index: 1
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
Abstract Matrix metalloproteinases (MMPs) are proteases that destroy the extracellular matrix and have important roles in the foreign body response, wound healing, and disease. Of particular importance is the chronic wound environment in which MMP activity is increased, resulting in destruction of the de novo extracellular matrix. One potential treatment of these wounds would be to use dressings that are capable of inhibiting MMP activity. In this study, we examined the effect of seven polymer m...
1 CitationsSource