Kaitlin M. Bratlie
Iowa State University
Self-healing hydrogelsAnalytical chemistryBiophysicsPhenotypeBiomedical engineeringAdsorptionInfrared spectroscopyCatalysisNanotechnologyChemistryMaterials scienceArginineBenzeneBiomaterialMacrophageDrug deliveryWound healingChemical engineeringTissue engineeringPlatinumCell biology
72Publications
22H-index
2,389Citations
Publications 68
Newest
#1Tanzeel Ur Rehman (Iowa State University)
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
A library of arginine-like surface modifiers was tested to improve the targetability of DOPE:DOPC liposomes towards myofibroblasts in a tumor microenvironment. Liposomes were characterized using zeta potential and dynamic light scattering. Cell viability remained unchanged for all liposomes. Liposomes were encapsulated using doxorubicin with an encapsulation efficiency >94%. The toxicity of doxorubicin-loaded liposomes was calculated via half-maximal inhibitory concentration (IC50) for fibroblas...
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#1Zhuqing Li (Iowa State University)H-Index: 2
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
Macrophage polarization is a key factor in determining the success of implanted tissue engineering scaffolds. Polysaccharides (derived from plants, animals, and microorganisms) are known to modulate macrophage phenotypes by recognizing cell membrane receptors. Numerous studies have developed polysaccharide-based materials into functional biomaterial substrates for tissue regeneration and pharmaceutical application due to their immunostimulatory activities and anti-inflammatory response. They are...
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Multifunctional two-dimensional nanosheet materials have attracted attention in biomedical fields due to their unique physiochemical and biological properties. Interactions between intestinal stem cells and Engineered Nanomaterials (ENMs) are an essential area in research with the growing diagnosis of gastrointestinal (GI) diseases. One unique type of two-dimensional metal carbide nanomaterial, niobium carbide (Nb2 C), has shown promising properties for potential applications in this field, such...
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#1Zhuqing Li (Iowa State University)H-Index: 2
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
Abstract In tissue regeneration, the goal is to regenerate tissue similar to what was damaged or missing while preventing fibrotic scarring, which may lead to decreased mechanical strength and dissimilar tissue characteristics compared to native tissue. We believe collagen orientation plays a critical role in wound contraction and scarring and that it is modulated by myofibroblasts. We used macrophage conditioned medium to simulate complex events that can influence the fibroblast phenotype durin...
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#1Zihao Xu (Iowa State University)H-Index: 4
#2Dohgyu Hwang (Iowa State University)H-Index: 5
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
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Abstract Adhesion of macrophages to material substrates plays an essential role in many biological behaviors and biomedical procedures, including wound healing, cancer treatment and biomaterial implantation. Therefore, altering the adhesion of macrophages using biomaterial design may help control their biological function. In this work, we developed a straightforward method to render the hydrogel surface more hydrophobic and demonstrated that the adhesion of macrophages on hydrogels was enhanced...
2 CitationsSource
#1Clarence C. King (WSU: Washington State University)H-Index: 1
#2Amelia Ann Brown (WSU: Washington State University)H-Index: 1
Last. Scott P. Beckman (WSU: Washington State University)H-Index: 20
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#1Anuraag Boddupalli (Iowa State University)H-Index: 4
#2Dana Akilbekova (Iowa State University)H-Index: 8
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
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Abstract Functionalized biomaterials interface with tissue upon implantation. There is a growing need to understand how materials properties influence this interaction so that efficient tissue engineering systems can be developed. In this study, we characterize collagen organization in response to functionalized glass beads implanted in SKH1-E mice. Poly- l -arginine (PLR) was modified with arginine derivatives to create a functionalized surface and was coated on glass beads. Tissue sections wer...
1 CitationsSource
#1Ryan A. Koppes (NU: Northeastern University)H-Index: 14
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
Last. Iman Noshadi (Rowan University)H-Index: 4
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#1Zihao Xu (Iowa State University)H-Index: 4
#2Dohgyu Hwang (Iowa State University)H-Index: 5
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
view all 5 authors...
A balance of macrophage phenotypes is essential in successful implantation. Therefore, biomaterials should be carefully designed to better regulate the response of macrophages. We demonstrate macrophage adhesion and phenotypic shifts can be modulated with hydrophobically modified hydrogels. This study represents a fundamental concept in controlling cell adhesion and differentiation with substrate hydrophobicity. Gel synthesis was carried out using methacrylated gellan gum (MGG), which was polyme...
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#1Yijun Qi (Iowa State University)H-Index: 6
#2Jo Lohman (Iowa State University)H-Index: 1
Last. Qun Wang (Iowa State University)H-Index: 50
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: Vitamin C (ascorbic acid) and vitamin B3 (niacin) have been extensively studied since the 20th century. In the area of stem cell biology, vitamin C has shown its direct impact toward homeostasis and epigenetic changes (D'Aniello et al., Stem Cells International, 2017, 1-16). Vitamin B3 aids in maintaining healthy intestinal homeostasis and reducing gut inflammation by participating in the rapamycin signaling pathway (Kumar et al., The American Journal of Physiology-Gastrointestinal and Liver P...
5 CitationsSource