Zachary S. Wallace
Harvard University
EpidemiologyInternal medicineAntibodyMortality rateRheumatologyCohort studyImmunologyHazard ratioVasculitisDiseaseMEDLINEIgG4-related diseaseRituximabGranulomatosis with polyangiitisPopulationMedicineCohortPandemicGastroenterology
114Publications
25H-index
3,678Citations
Publications 107
Newest
PURPOSE OF REVIEW: The coronavirus disease 2019 (COVID-19) pandemic has caused significant morbidity and mortality worldwide. Patients with rheumatoid arthritis (RA) face unique challenges during the pandemic, including concerns regarding infection risk, drug shortages, limited access to care, social isolation, and mental health. This review will examine the multifaceted impacts of the COVID-19 pandemic on patients living with RA. RECENT FINDINGS: In patients with RA, risk factors for severe COV...
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#1Kristin M D’Silva (Harvard University)H-Index: 8
#2Naomi Serling-Boyd (Harvard University)H-Index: 5
Last. Zachary S. Wallace (Harvard University)H-Index: 25
view all 6 authors...
We appreciate the comments by Brito et al ,1 and Zhao et al ,2 in response to our manuscript evaluating outcomes among a cohort of patients with rheumatic diseases and COVID-19.3 We were interested to read the reports of their patients during the COVID-19 pandemic and would like to reply to some of their queries. Brito et al raised the important point that the risk of severe infections may vary with therapeutic class of immunosuppressive therapy. We agree that further studies are needed to asses...
1 CitationsSource
#1Naomi Serling-Boyd (Harvard University)H-Index: 5
#2Kristin M D’Silva (Harvard University)H-Index: 8
Last. Zachary S. Wallace (Harvard University)H-Index: 25
view all 11 authors...
Objective In earlier studies, patients with rheumatic and musculoskeletal disease (RMD) who got infected with COVID-19 had a higher risk of mechanical ventilation than comparators. We sought to determine COVID-19 outcomes among patients with RMD 6 months into the pandemic. Methods We conducted a cohort study at Mass General Brigham in Boston, Massachusetts, of patients with RMD matched to up to five comparators by age, sex and COVID-19 diagnosis date (between 30 January 2020 and 16 July 2020) an...
11 CitationsSource
#1Kristin M D’Silva (Harvard University)H-Index: 8
#2Zachary S. Wallace (Harvard University)H-Index: 25
PURPOSE OF REVIEW Patients on disease-modifying anti-rheumatic drugs (DMARDs) remain concerned about potential risks of severe COVID-19 outcomes. Meanwhile, several DMARDs have been proposed as COVID-19 therapies. RECENT FINDINGS In patients with autoimmune diseases, baseline glucocorticoid use is associated with severe COVID-19. While classes of DMARDs (e.g., conventional synthetic, targeted synthetic, and biologic) do not appear to be associated with higher risk, specific medications such as r...
1 CitationsSource
#1Kristin M D’Silva (Harvard University)H-Index: 8
#2Naomi Serling-Boyd (Harvard University)H-Index: 5
Last. Zachary S. Wallace (Harvard University)H-Index: 25
view all 5 authors...
We appreciate the comments by Shanoj et al 1 in response to our letter regarding the SARS-CoV-2 antibody response after COVID-19 in patients with rheumatic disease.2 Examining whether patients treated with CD20 inhibitors have antibody responses to SARS-CoV-2 is a question of great clinical importance in the management and vaccination of patients taking these medications during the COVID-19 pandemic. Shanoj et al describe anti-spike and anti-nucleocapsid antibody test results among five patients...
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#1Rachel Wallwork (Harvard University)H-Index: 6
#2Cory A. Perugino (Harvard University)H-Index: 13
Last. Zachary S. Wallace (Harvard University)H-Index: 25
view all 8 authors...
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#1Lacey B. Robinson (Harvard University)H-Index: 3
#2Liqin Wang (Harvard University)H-Index: 6
Last. Kimberly G. Blumenthal (Harvard University)H-Index: 24
view all 8 authors...
The evidence pertaining to the effects of asthma on Coronavirus disease 2019 outcomes has been unclear. To improve our understanding of the clinically important association of asthma and Coronaviru...
1 CitationsSource
#1Milena A. Gianfrancesco (UCSF: University of California, San Francisco)H-Index: 17
#2Liza A. Leykina (UCSF: University of California, San Francisco)H-Index: 1
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Objective Racial/ethnic minorities experience more severe outcomes of COVID-19 in the general United States (US) population. The aim of this study was to examine the association between race/ethnicity and COVID-19 hospitalization, ventilation status, and mortality in people with rheumatic disease. Methods US patients with rheumatic disease and COVID-19 entered into the COVID-19 Global Rheumatology Alliance physician registry March 24 - August 26, 2020 were included. Race/ethnicity was defined as...
6 CitationsSource
#1Damian R. Plichta (Broad Institute)H-Index: 14
#2Juhi Somani (Aalto University)H-Index: 2
Last. Ramnik J. Xavier (Broad Institute)H-Index: 124
view all 13 authors...
BACKGROUND Immunoglobulin G4-related disease (IgG4-RD) and systemic sclerosis (SSc) are rare autoimmune diseases characterized by the presence of CD4+ cytotoxic T cells in the blood as well as inflammation and fibrosis in various organs, but they have no established etiologies. Similar to other autoimmune diseases, the gut microbiome might encode disease-triggering or disease-sustaining factors. METHODS The gut microbiomes from IgG4-RD and SSc patients as well as healthy individuals with no rece...
1 CitationsSource
#1Liqin Wang (Harvard University)H-Index: 6
#2Eli M. Miloslavsky (Harvard University)H-Index: 14
Last. Zachary S. Wallace (Harvard University)H-Index: 25
view all 6 authors...
Abstract Objectives Clinical notes from electronic health records (EHR) are important to characterize the natural history, comorbidities, and complications of ANCA-associated vasculitis (AAV) because these details may not be captured by claims and structured data. However, labor-intensive chart review is often required to extract information from notes. We hypothesized that machine learning can automatically discover clinically-relevant themes across longitudinal notes to study AAV. Methods This...
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