Yoh Zen
King's College London
Internal medicineRadiologyPathologyImmunohistochemistryBiopsyPancreatitisCarcinomaHepatocellular carcinomaAutoimmune pancreatitisPancreasDiseaseBile ductIgG4-related diseaseFibrosisPrimary sclerosing cholangitisAdenocarcinomaCancer researchMedicineBiologyGastroenterology
Publications 371
#1Dustin E Bosch (UW: University of Washington)H-Index: 5
#2Yoh Zen ('KCL': King's College London)H-Index: 87
Last. Matthew M. Yeh (UW: University of Washington)H-Index: 53
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Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are biliary tract pathologies with increased risk of HCC, although HCC is more commonly associated with viral hepatitis and steatohepatitis. HCC risk stratification in PBC/PSC populations may help select patients for surveillance. We hypothesized that metabolic syndrome associated diagnoses and co-morbid nonalcoholic fatty liver disease (NAFLD) may be risk factors for HCC in patients with PBC and PSC. We undertook a multi...
#1Kshitij Arora (UM: University of Miami)H-Index: 1
#2Mark AndersonH-Index: 27
Last. Vikram DeshpandeH-Index: 120
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Inflammatory pseudotumor is a term used to designate inflammation-rich tumefactive lesions. Following the exclusion of specific entities such as IgG4-related disease and other neoplastic entities previously included in this entity, the majority of hepatic pseudotumors show a prominent fibrohistiocytic inflammatory reaction and have been previously categorized as fibrohistiocytic variant of hepatic pseudotumor (FHVHPT). The goal of this study was to examine the clinical, radiologic, histologic, a...
#1Yun Ma ('KCL': King's College London)H-Index: 35
#2Haibin Su ('KCL': King's College London)H-Index: 56
Last. Giorgina Mieli-Vergani (University of Cambridge)H-Index: 91
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Background and aims Genetic predisposition to autoimmune hepatitis (AIH) in adults is associated with possession of HLA class I (A*01, B*08) and class II alleles (DRB1*03, -04, -07 or -13), depending on geographic regions. Juvenile autoimmune liver disease (AILD) comprises AIH-1, AIH-2 and autoimmune sclerosing cholangitis (ASC), which are phenotypically different from their adult counterparts. We aimed to define the relationship between HLA profile and disease course, severity and outcome in ju...
2 CitationsSource
#1Kaushal Kundalia (University of Cambridge)
#2Abdul Hakeem (Leeds Teaching Hospitals NHS Trust)
Last. Krishna MenonH-Index: 9
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INTRODUCTION Margin accentuation (MA) using Irreversible electroporation (IRE) offers an unique opportunity to reduce the R1 resections in resectable pancreatic cancer (RPC). This study aims to assess the rate of margin positivity using IRE for MA during pancreaticoduodenectomy (PD) for resectable pancreatic head tumours. MATERIALS AND METHODS Following ethical approval, MA using IRE was carried out in 20 consecutive patients to posterior and superior mesenteric vein (SMV) margin, and the pancre...
#1Shintaro Kanaka (Nippon Medical School)H-Index: 1
#2Youichi Kawano (Nippon Medical School)H-Index: 16
Last. Hiroshi Yoshida (Nippon Medical School)H-Index: 41
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Immunoglobulin G4 (IgG4) -related disease (IgG4-RD) is a recently characterized entity in which lymphocytes and plasma cells infiltrate various anatomical sites. IgG4-hepatopathy, which is the manifestation of IgG4-RD, is a broader term covering various patterns of liver injury. The clinical course including the malignant potential of IgG4-RD remains unclear. Here we report the first case of secondary hemochromatosis and hepatocellular carcinoma (HCC) developed from IgG4-hepatopathy. A 67-year-o...
#1Ai KawadaH-Index: 3
#2Shinichi IwamuraH-Index: 3
Last. Kunihisa UchitaH-Index: 9
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The onset of autoimmune hepatitis (AIH) during pregnancy is rare and often poses a diagnostic challenge. A 29-year-old Japanese woman experienced epigastric pain and nausea during the third trimester of her third pregnancy. Three days after the symptom onset, an emergency Caesarean section was performed because of suspected acute fatty liver of pregnancy; however, the patient's liver dysfunction worsened afterward. Despite normal serum IgG concentration and absence of autoantibodies, biopsy-prov...
#1Sonoko IshidaH-Index: 2
#2Masayuki AkitaH-Index: 10
Last. Yoh Zen ('KCL': King's College London)H-Index: 87
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The gene mutation profiles of gastric neuroendocrine neoplasms are incompletely understood. The purpose of this study was to characterize the molecular pathology of poorly differentiated neuroendocrine carcinoma (NEC) and mixed neuroendocrine‒non-neuroendocrine neoplasm (MiNEN) of the stomach. Surgical cases of gastric NEC (n=7) and MiNEN (n=6) were examined by clinical review, immunohistochemistry, microsatellite instability (MSI) analysis and whole exome sequencing. NEC cases consisted of smal...
#1Hiroaki Kanzaki (Chiba University)H-Index: 5
#2Tetsuhiro Chiba (Chiba University)H-Index: 32
Last. Naoya Kato (Chiba University)H-Index: 17
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FGF19/FGFR4 autocrine signaling is one of the main targets for multi-kinase inhibitors (MKIs). However, the molecular mechanisms underlying FGF19/FGFR4 signaling in the antitumor effects to MKIs in hepatocellular carcinoma (HCC) remain unclear. In this study, the impact of FGFR4/ERK signaling inhibition on HCC following MKI treatment was analyzed in vitro and in vivo assays. Serum FGF19 in HCC patients treated using MKIs, such as sorafenib (n = 173) and lenvatinib (n = 40), was measured by enzym...
1 CitationsSource
#1Masayuki Akita (Kobe University)H-Index: 10
#2Ryuichiro Sawada (JFCR: Japanese Foundation for Cancer Research)H-Index: 4
Last. Yoh Zen ('KCL': King's College London)H-Index: 87
view all 9 authors...
This study aimed to establish an immunohistochemical panel useful for subclassification of intrahepatic cholangiocarcinoma (iCCA) into small- and large-duct types. Fifty surgical cases of iCCA consisting of small- (n=31) and large-duct types (n=19) were examined. In order to imitate liver needle biopsies, tissue microarrays were constructed using three tissue cores (2 mm in diameter) obtained from one representative paraffin block of each case. Immunostaining for C-reactive protein (CRP), N-cadh...
#1Yooyun Chung (University of Cambridge)
#2Mussarat N. Rahim (University of Cambridge)H-Index: 2
Last. Michael A. Heneghan (University of Cambridge)H-Index: 56
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INTRODUCTION Autoimmune hepatitis (AIH) is an immune mediated, inflammatory disease affecting the liver as a result of environmental triggers in susceptible individuals leading to loss of self-tolerance. The immunopathogenesis of AIH is not fully understood which limits targeted therapeutic options. AREAS COVERED In this review, the authors provide an overview of current practice in the management of AIH which include induction therapy with corticosteroids (+/- thiopurines), followed by maintena...