Yoh Zen
Kobe University
RadiologyPathologyImmunohistochemistryBiopsyPancreatitisIntraductal papillary mucinous neoplasmAutoimmune hepatitisCarcinomaHepatocellular carcinomaAutoimmune pancreatitisPancreasBile ductIgG4-related diseaseFibrosisPrimary sclerosing cholangitisAdenocarcinomaCancer researchMedicineBiologyGastroenterology
Publications 356
#1Yun Ma ('KCL': King's College London)H-Index: 34
#2Habin Su ('KCL': King's College London)
Last. Giorgina Mieli-Vergani (University of Cambridge)H-Index: 70
view all 19 authors...
Background and aims Genetic predisposition to autoimmune hepatitis (AIH) in adults is associated with possession of HLA class I (A*01, B*08) and class II alleles (DRB1*03, -04, -07 or -13), depending on geographic regions. Juvenile autoimmune liver disease (AILD) comprises AIH-1, AIH-2 and autoimmune sclerosing cholangitis (ASC), which are phenotypically different from their adult counterparts. We aimed to define the relationship between HLA profile and disease course, severity and outcome in ju...
#2Abdul R. HakeemH-Index: 11
Last. Krishna MenonH-Index: 10
view all 15 authors...
#1Shintaro Kanaka (Nippon Medical School)H-Index: 1
#2Youichi Kawano (Nippon Medical School)H-Index: 14
Last. Hiroshi Yoshida (Nippon Medical School)H-Index: 34
view all 10 authors...
Immunoglobulin G4 (IgG4) -related disease (IgG4-RD) is a recently characterized entity in which lymphocytes and plasma cells infiltrate various anatomical sites. IgG4-hepatopathy, which is the manifestation of IgG4-RD, is a broader term covering various patterns of liver injury. The clinical course including the malignant potential of IgG4-RD remains unclear. Here we report the first case of secondary hemochromatosis and hepatocellular carcinoma (HCC) developed from IgG4-hepatopathy. A 67-year-o...
#1Ai KawadaH-Index: 3
#2Shinichi IwamuraH-Index: 3
Last. Kunihisa UchitaH-Index: 8
view all 9 authors...
The onset of autoimmune hepatitis (AIH) during pregnancy is rare and often poses a diagnostic challenge. A 29-year-old Japanese woman experienced epigastric pain and nausea during the third trimester of her third pregnancy. Three days after the symptom onset, an emergency Caesarean section was performed because of suspected acute fatty liver of pregnancy; however, the patient's liver dysfunction worsened afterward. Despite normal serum IgG concentration and absence of autoantibodies, biopsy-prov...
#1Sonoko IshidaH-Index: 2
#2Masayuki AkitaH-Index: 9
Last. Yoh Zen ('KCL': King's College London)H-Index: 69
view all 10 authors...
The gene mutation profiles of gastric neuroendocrine neoplasms are incompletely understood. The purpose of this study was to characterize the molecular pathology of poorly differentiated neuroendocrine carcinoma (NEC) and mixed neuroendocrine‒non-neuroendocrine neoplasm (MiNEN) of the stomach. Surgical cases of gastric NEC (n=7) and MiNEN (n=6) were examined by clinical review, immunohistochemistry, microsatellite instability (MSI) analysis and whole exome sequencing. NEC cases consisted of smal...
#1Yooyun Chung (University of Cambridge)
#2Mussarat N. Rahim (University of Cambridge)H-Index: 1
Last. Michael A. Heneghan (University of Cambridge)H-Index: 46
view all 5 authors...
INTRODUCTION Autoimmune hepatitis (AIH) is an immune mediated, inflammatory disease affecting the liver as a result of environmental triggers in susceptible individuals leading to loss of self-tolerance. The immunopathogenesis of AIH is not fully understood which limits targeted therapeutic options. AREAS COVERED In this review, the authors provide an overview of current practice in the management of AIH which include induction therapy with corticosteroids (+/- thiopurines), followed by maintena...
#1Hiroaki Kanzaki (Chiba University)H-Index: 5
#2Tetsuhiro Chiba (Chiba University)H-Index: 32
Last. Naoya Kato (Chiba University)H-Index: 15
view all 31 authors...
FGF19/FGFR4 autocrine signaling is one of the main targets for multi-kinase inhibitors (MKIs). However, the molecular mechanisms underlying FGF19/FGFR4 signaling in the antitumor effects to MKIs in hepatocellular carcinoma (HCC) remain unclear. In this study, the impact of FGFR4/ERK signaling inhibition on HCC following MKI treatment was analyzed in vitro and in vivo assays. Serum FGF19 in HCC patients treated using MKIs, such as sorafenib (n = 173) and lenvatinib (n = 40), was measured by enzym...
#1Masayuki Akita (Kobe University)H-Index: 9
#2Ryuichiro Sawada (JFCR: Japanese Foundation for Cancer Research)H-Index: 4
Last. Yoh Zen ('KCL': King's College London)H-Index: 69
view all 9 authors...
This study aimed to establish an immunohistochemical panel useful for subclassification of intrahepatic cholangiocarcinoma (iCCA) into small- and large-duct types. Fifty surgical cases of iCCA consisting of small- (n=31) and large-duct types (n=19) were examined. In order to imitate liver needle biopsies, tissue microarrays were constructed using three tissue cores (2 mm in diameter) obtained from one representative paraffin block of each case. Immunostaining for C-reactive protein (CRP), N-cadh...
#2Guido Stirnimann (University of Bern)H-Index: 12
Last. Giorgina Mieli-Vergani ('KCL': King's College London)H-Index: 70
view all 15 authors...
Abstract Background & aim The diagnosis of primary biliary cholangitis (PBC), an uncommon immune-mediated cholestatic liver disease, is based on positive circulating anti-mitochondrial (AMA) and/or PBC-specific anti-nuclear autoantibodies (ANA), coupled with elevated serum alkaline phopsphatase (ALP) levels. Timely initiation of treatment with ursodeoxycholic acid prevents progression to cirrhosis and liver failure. We aimed at investigating liver histology in patients with normal ALP level and ...
#1Bushra Kanwal (UCL: University College London)
#2Yoh Zen (University of Cambridge)H-Index: 69
Last. Aamir Ahmed ('KCL': King's College London)H-Index: 20
view all 7 authors...