Guido Reber
University of Geneva
Internal medicineRadiologyEndocrinologySurgeryPathologyMolecular biologyAntibodyChemistryPredictive value of testsImmunologyRespiratory diseasePulmonary embolismAntiphospholipid syndromeAnticoagulantD-dimerVenous thrombosisLupus anticoagulantThrombosisBeta 2-Glycoprotein INuclear medicineVenous thromboembolismMedicineBiologyPlateletGastroenterologyPharmacology
Publications 155
#1Nathalie SattaH-Index: 15
#2Guido ReberH-Index: 44
Last. Philippe de MoerlooseH-Index: 44
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The antiphospholipid syndrome is characterized by clinical manifesta- tions (thrombosis and/or pregnancy morbidity) associated with the so-called antiphospholipid antibodies (aPL). These antibodies are in fact mainly directed against protein-phospholipid complexes, the main protein being b2-glycoprotein 1. After a brief review on the syndrome and its diagnosis, we will discuss the possible mechanisms responsible for the clinical complications. aPL can interfere directly with the coagulation syst...
AbstractBackground. Rheumatoid arthritis (RA) is a risk factor for the development of Felty's syndrome and large granular lymphocyte (LGL) leukemia. Anti-cyclic citrullinated peptide (CCP) antibodies are considered highly specific for RA and are directed against various citrullinated antigens, including citrullinated fibrinogen. Anti-CCP antibodies may interfere with the detection of citrullinated proteins and their function. In this article, we describe the possible inhibition of fibrinogen by ...
#1Michael NaglerH-Index: 14
#2Lucas M. BachmannH-Index: 5
Last. Walter A. WuilleminH-Index: 35
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Background: While the assessment of analytical precision within medical laboratories has received much attention in scientific enquiry, the degree of as well as the sources causing variation between them remains incompletely understood. In this study, we quantified the variance components when performing coagulation tests with identical analytical platforms in different laboratories and computed intraclass correlations coefficients (ICC) for each coagulation test. Methods: Data from eight labora...
17 CitationsSource
#1Guido ReberH-Index: 44
#1Guido ReberH-Index: 21
Last. P. De Moerloose (Geneva College)H-Index: 23
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4 CitationsSource
Less than 60 cases of acquired factor (F)XIII deficiencies have been reported, most having distinct clinical features. To illustrate the therapeutic challenges of acquired FXIII inhibitors, we report a case of a 65-year-old patient with no previous bleeding history who suddenly developed massive haemorrhages associated to a strong and isolated FXIII inhibitor. No underlying disorder has been detected till now after three years of follow-up. Despite aggressive treatment with prednisone, rituximab...
41 CitationsSource
#1Karim J. Brandt (University of Geneva)H-Index: 12
#2Céline Fickentscher (University of Geneva)H-Index: 5
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Introduction Antiphospholipid antibody syndrome (APS) is an auto-immune disease associated with arterial or venous thrombosis and/or recurrent fetal loss and is caused by pathogenic antiphospholipid antibodies (aPLA). We recently demonstrated TLR2 as a crucial factor in recognizing aPLA by monocytes. While TLR4 is known to transmit signals from both the plasma membrane and endosomal compartments, less is known about the function of endosomal trafficking on TLR2 signaling. Methods Primary human m...
#1Sophie Stoppa-Vaucher (Boston Children's Hospital)H-Index: 7
#2Mirjam Dirlewanger (Boston Children's Hospital)H-Index: 6
Last. Valerie M. Schwitzgebel (Boston Children's Hospital)H-Index: 18
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Adipose tissue may release mediators that induce a chronic inflammatory state and alterations in coagulation, which contribute to insulin resistance, atherosclerosis, and thrombosis. We investigated whether inflammatory and/or prothrombotic states exist in obese children and assessed their interrelationship. Sixty-one subjects were recruited, aged between 6 and 16 years, to participate in a cross-sectional study at Children's University Hospital of Geneva. Selected pro/anti-inflammatory cytokine...
33 CitationsSource
#1Lars M. Asmis (UZH: University of Zurich)H-Index: 17
#2Lorenzo AlberioH-Index: 25
Last. Walter A. WuilleminH-Index: 35
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article i nfo Introduction: Rivaroxaban (RXA) is licensed for prophylaxis of venous thromboembolism after major orthopaedic surgery of the lower limbs. Currently, no test to quantify RXA in plasma has been validated in an inter-laboratory setting. Our study had three aims: to assess i) the feasibility of RXA quantification with a commercial anti-FXa assay, ii) its accuracy and precision in an inter-laboratory setting, and iii) the influence of 10 mg of RXA on routine coagulation tests. Methods: ...
121 CitationsSource
#1Nathalie SattaH-Index: 15
Last. Philippe de MoerlooseH-Index: 44
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The presence of antiphospholipid antibodies (aPLAs) is associated with arterial or venous thrombosis and/or recurrent fetal loss. The proposed pathogenic mechanisms for aPLA effects include the inflammatory activation of monocytes and endothelial cells. Toll-like receptors (TLRs) are candidate signaling intermediates. The aim of this study was to investigate the relative contribution of TLR2 and TLR4 in cell activation by aPLAs. Of 32 patient-derived aPLAs, 19 induced an inflammatory activation ...
84 CitationsSource