Mitzi Nagarkatti
University of South Carolina
Internal medicineEndocrinologymicroRNACannabinoid receptorMolecular biologyProinflammatory cytokineReceptorChemistryApoptosisImmunologyColitisT cellInflammationCytokineCancer researchMedicineBiologyImmune systemCell biologyPharmacology
367Publications
66H-index
10.4kCitations
Publications 345
Newest
#1Peng Yang (USC: University of South Carolina)H-Index: 8
#2Yuanyuan Luo (USC: University of South Carolina)
Last. Chuanbing Tang (USC: University of South Carolina)H-Index: 56
view all 8 authors...
This paper reports antimicrobial metallopolymers containing biodegradable polycaprolactone as the backbone with boronic acid and cobaltocenium as the side chain. While boronic acid promotes interactions with bacterial cells via boronolectin with lipopolysaccharides, cationic cobaltocenium facilitates the unique complexation with anionic β-lactam antibiotics. The synergistic interactions in these metallopolymer-antibiotic bioconjugates were evidenced by re-sensitized efficacy of penicillin-G agai...
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#1Ayan Mondal (USC: University of South Carolina)H-Index: 6
#2Punnag Saha (USC: University of South Carolina)H-Index: 4
Last. Mitzi Nagarkatti (USC: University of South Carolina)H-Index: 66
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Abstract null null Nonalcoholic fatty liver disease (NAFLD) has been shown to be associated with extrahepatic comorbidities including neuronal inflammation and Alzheimer’s-like pathology. Environmental and genetic factors also act as a second hit to modulate severity and are expected to enhance the NAFLD-linked neuropathology. We hypothezied that environmental microcystin-LR (MC-LR), a toxin produced by harmful algal blooms of cyanobacteria, exacerbates the neuroinflammation and degeneration of ...
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The current spreading coronavirus SARS-CoV-2 is highly infectious and pathogenic. In this study, we screened the gene expression of three host receptors (ACE2, DC-SIGN and L-SIGN) of SARS coronaviruses and dendritic cells (DCs) status in bulk and single cell transcriptomic datasets of upper airway, lung or blood of COVID-19 patients and healthy controls. In COVID-19 patients, DC-SIGN gene expression was interestingly decreased in lung DCs but increased in blood DCs. Within DCs, conventional DCs ...
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#1Dan Xue (USC: University of South Carolina)
#2Ethan A. Older (USC: University of South Carolina)
Last. Xiaoyu TangH-Index: 13
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Bacterial natural product biosynthetic genes, canonically clustered, have been increasingly found to rely on cryptic enzymes encoded elsewhere in the genome for completion of biosynthesis. The study and application of lanthipeptides are frequently hindered by cryptic proteases required for final maturation. Here, we establish a global correlation network bridging the gap between lanthipeptide precursors and cryptic proteases. Applying our analysis to 161,954 bacterial genomes, we establish 5,209...
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#1Dan Xue (USC: University of South Carolina)
#2Ethan A. Older (USC: University of South Carolina)
Last. Mitzi Nagarkatti (USC: University of South Carolina)H-Index: 66
view all 12 authors...
Proteases required for lanthipeptide maturation are not encoded in many of their respective biosynthetic gene clusters. These cryptic proteases hinder the study and application of lanthipeptides as promising drug candidates. Here, we establish a global correlation network bridging the gap between lanthipeptide precursors and cryptic proteases. Applying our analysis to 161,954 bacterial genomes, we establish 6,041 correlations between precursors and cryptic proteases, with 91 prioritized. We use ...
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#1Piper A Robida (USC: University of South Carolina)
#2Alena P. Chumanevich (USC: University of South Carolina)H-Index: 11
Last. Carole A. Oskeritzian (USC: University of South Carolina)H-Index: 26
view all 7 authors...
Atopic dermatitis (AD or eczema) is the most common chronic inflammatory skin disorder worldwide. Ceramides (Cer) maintain skin barrier functions, which are disrupted in lesional skin of AD patients. However, Cer status during the pre-lesional phase of AD is not well defined. Using a variation of human AD-like preclinical model consisting of a 7-day topical exposure to ovalbumin (OVA), or control, we observed elevation of Cer C16 and C24. Skin mRNA quantification of enzymes involved in Cer metab...
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#1Punnag SahaH-Index: 4
#2Peter T. SkidmoreH-Index: 1
Last. Nancy G. KlimasH-Index: 73
view all 14 authors...
Gulf War Illness (GWI) is a chronic multi-symptomatic illness that is associated with fatigue, pain, cognitive deficits, and gastrointestinal disturbances and presents a significant challenge to treat in clinics. Our previous studies show a role of an altered Gut–Brain axis pathology in disease development and symptom persistence in GWI. The present study utilizes a mouse model of GWI to study the role of a labdane diterpenoid andrographolide (AG) to attenuate the Gut–Brain axis-linked pathology...
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Chronic inflammation is considered to be a silent killer because it is the underlying cause of a wide range of clinical disorders, from cardiovascular to neurological diseases, and from cancer to obesity. In addition, there are over 80 different types of debilitating autoimmune diseases for which there are no cure. Currently, the drugs that are available to suppress chronic inflammation are either ineffective or overtly suppress the inflammation, thereby causing increased susceptibility to infec...
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#1Lukuan Hou (USC: University of South Carolina)
#2Ying Li (MUC: Minzu University of China)
Last. Jie Li (USC: University of South Carolina)H-Index: 44
view all 14 authors...
Abstract Antibiotic resistance and emerging viral pandemics have posed an urgent need for new anti-infective drugs. By screening our microbial extract library against the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the notorious ESKAPE pathogens, an active fraction was identified and purified, leading to an initial isolation of adipostatins A (1) and B (2). In order to diversify the chemical structures of adipostatins toward enhanced biological activities, a...
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#1William Becker (USC: University of South Carolina)H-Index: 2
#2Haider Rasheed Alrafas (USC: University of South Carolina)H-Index: 4
Last. Prakash S. Nagarkatti (USC: University of South Carolina)H-Index: 72
view all 11 authors...
Background and aims Cannabinoid receptor (CB) activation can attenuate inflammatory bowel disease (IBD) in experimental models and human cohorts. However, the role of the microbiome, metabolome, or the respective contributions of hematopoietic and non-hematopoietic cells in the anti-colitic effects of cannabinoids has yet to be determined. Methods Female C57BL/6 mice were treated with either cannabidiol (CBD), Δ 9-tetrahydrocannabinol (THC), a combination of CBD and THC or vehicle, in several mo...
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