Herman Favoreel
Ghent University
GlycoproteinActinInternalizationViral replicationCytoskeletonCellMolecular biologyVirologyAntibodyReceptorImmunologyVirusPseudorabiesHerpes simplex virusEndocytosisActin cytoskeletonBiologyImmune systemMicrobiologyCell biology
174Publications
39H-index
3,628Citations
Publications 174
Newest
The nuclear factor kappa B (NF-κB) pathway is known to integrate signaling associated with very diverse intra- and extracellular stressors, including virus infections, and triggers a powerful (proinflammatory) response through the expression of NF-κB-regulated genes. Typically, the NF-κB pathway collects and transduces threatening signals at the cell surface or in the cytoplasm leading to nuclear import of activated NF-κB transcription factors. In the current work, we demonstrate that the swine ...
Source
Both type I and III interferons (IFNs) play a crucial role in host antiviral response by activating the JAK/STAT (Janus kinase/signal transducer and activator of transcription) signaling pathway to trigger the expression of antiviral IFN-stimulated genes (ISGs). We report that the porcine alphaherpesvirus pseudorabies virus (PRV) triggers proteasomal degradation of the key Janus kinases Jak1 and to a lesser extent Tyk2, thereby inhibiting both type I and III IFN-induced STAT1 phosphorylation and...
Source
#1Leen Hermans (UGent: Ghent University)H-Index: 1
#2Steffi De Pelsmaeker (UGent: Ghent University)H-Index: 7
Last. Bert Devriendt (UGent: Ghent University)H-Index: 19
view all 6 authors...
Beta glucans are naturally occurring polysaccharides present in cell walls of fungi, yeast, bacteria, cereals, seaweed and algae. These microbe-associated molecular patterns (MAMPs) possess immunomodulatory properties. In human, it has been suggested that NK cells can be activated by β glucans. Here, we aimed to elucidate whether β glucans modulate porcine NK cell responses in vitro and if so, how these effects are mediated. We investigated the effect of two β glucans, Macrogard and Curdlan, whi...
Source
#1Sofie Denaeghel (UGent: Ghent University)H-Index: 1
#2Steffi De Pelsmaeker (UGent: Ghent University)H-Index: 7
Last. Herman Favoreel (UGent: Ghent University)H-Index: 39
view all 4 authors...
Herpesviruses display a complex and carefully balanced interaction with important players in the antiviral immune response of immunocompetent natural hosts, including natural killer (NK) cells. With regard to NK cells, this delicate balance is illustrated on the one hand by severe herpesvirus disease reported in individuals with NK cell deficiencies and on the other hand by several NK cell evasion strategies described for herpesviruses. In the current study, we report that porcine cells infected...
Source
#1Yue Yin (UGent: Ghent University)H-Index: 1
#2Herman Favoreel (UGent: Ghent University)H-Index: 39
Type III interferons (IFNs) represent the most recently discovered group of IFNs. Together with type I IFNs (e.g. IFN-α/β), type III IFNs (IFN-λ) are produced as part of the innate immune response to virus infection, and elicit an anti-viral state by inducing expression of interferon stimulated genes (ISGs). It was initially thought that type I IFNs and type III IFNs perform largely redundant functions. However, it has become evident that type III IFNs particularly play a major role in antiviral...
Source
BACKGROUND Toll-like receptors (TLRs) are a family of transmembrane pattern recognition receptors that are mainly expressed on immune cells. Recognition of various exogenous and endogenous molecular patterns activates the TLR signalling cascade, which orchestrates an inflammatory immune response. Dysfunctional immune responses, including aberrant TLR signalling, are increasingly implicated in the associations between sedentarism, chronic low-grade systemic inflammation and various non-communicab...
#2Sandra Marmiroli (University of Modena and Reggio Emilia)H-Index: 29
Last. Herman FavoreelH-Index: 39
view all 3 authors...
The US3 serine/threonine protein kinase is conserved among the alphaherpesvirus family and represents an important virulence factor. US3 plays a role in viral nuclear egress, induces dramatic alterations of the cytoskeleton, represses apoptosis, enhances gene expression and modulates the immune response. Although several substrates of US3 have been identified, an unbiased screen to identify US3 phosphorylation targets has not yet been described. Here, we perform a shotgun and phosphoproteomics a...
Source
#1Jonas L. Delva (UGent: Ghent University)H-Index: 2
#2Hans Nauwynck (UGent: Ghent University)H-Index: 79
Last. Herman Favoreel (UGent: Ghent University)H-Index: 39
view all 4 authors...
Pseudorabies virus (PRV) is a member of the alphaherpesvirus subfamily of the herpesviruses and is the causative agent of Aujeszky's disease in pigs, causing respiratory, neurological, and reproductive symptoms. Given the heavy economic losses associated with Aujeszky's disease epidemics, great efforts were made to develop efficacious vaccines. One of the best modified live vaccines to this day is the attenuated Bartha K61 strain. The use of this vaccine in extensive vaccination programs worldwi...
Source
#1Valerie RedantH-Index: 1
#2Herman Favoreel (UGent: Ghent University)H-Index: 39
Last. Nick De ReggeH-Index: 15
view all 5 authors...
Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis in Asia. JEV infection of mice and humans can lead to an uncontrolled inflammatory response in the central nervous system (CNS), resulting in a detrimental outcome. Pigs act as important amplification and reservoir hosts, and JEV infection of pigs is mostly subclinical. Information on virus spread in the CNS and immune responses controlling JEV infection in the CNS of pigs, however remains scarce. Nine-week-old pigs wer...
Source
#1Nicolas Romero (UGent: Ghent University)H-Index: 2
#2Cliff Van Waesberghe (UGent: Ghent University)H-Index: 5
Last. Herman Favoreel (UGent: Ghent University)H-Index: 39
view all 3 authors...
The nuclear factor kappa B (NF-kappaB) is a potent transcription factor, activation of which typically results in robust pro-inflammatory signalling and triggering of fast negative feedback modulators to avoid excessive inflammatory responses. Here, we report that infection of epithelial cells, including primary porcine respiratory epithelial cells, with the porcine alphaherpesvirus pseudorabies virus (PRV) results in gradual and persistent activation of NF-kappaB, illustrated by proteasome-depe...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.