Hongmei Mou
Harvard University
AirwayInduced pluripotent stem cellEndothelial stem cellInternal medicinePathologyEmbryonic stem cellCellular differentiationCellBasal (phylogenetics)Cell typeProgenitor cellImmunologyAdult stem cellInflammationCystic fibrosisLungCystic fibrosis transmembrane conductance regulatorSMADStem cellPopulationTransepithelial MigrationTracheal EpitheliumCancer researchEpitheliumCancer stem cellCarcinogenesisCell growthMedicineBiologyRespiratory epitheliumImmune systemCell biology
Publications 37
#1Lael M. Yonker (Harvard University)H-Index: 13
#2Juliana Barrios (Harvard University)H-Index: 8
Last. Bryan P. Hurley (Harvard University)H-Index: 22
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Inflammation of the airway involves the recruitment of highly active immune cells to combat and clear microbes and toxic factors, however this inflammatory response can result in unintended damage to lung tissue. Tissue damage resulting from inflammation is often mitigated by resolving factors that limit the scope and duration of the inflammatory response. Both inflammatory and resolving processes require the actions of a vast array of lipid mediators that can be rapidly synthesized through a va...
#1Hongmei Mou (Harvard University)H-Index: 17
#2Ying Yang (CUMC: Columbia University Medical Center)H-Index: 8
Last. Xingbin Ai (Harvard University)H-Index: 23
view all 16 authors...
Summary Pulmonary neuroendocrine cells (PNECs) have crucial roles in airway physiology and immunity by producing bioactive amines and neuropeptides (NPs). A variety of human diseases exhibit PNEC hyperplasia. Given accumulated evidence that PNECs represent a heterogenous population of cells, we investigate how PNECs differ, whether the heterogeneity is similarly present in mouse and human cells, and whether specific disease involves discrete PNECs. Herein, we identify three distinct types of PNE...
1 CitationsSource
#1Brian M. LinH-Index: 24
#1Brian LinH-Index: 10
Last. Jayaraj RajagopalH-Index: 30
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3 CitationsSource
#1Junjie Lu (Harvard University)H-Index: 9
#2Xiaobo Zhu (SDU: Shandong University)H-Index: 1
Last. Paul H. Lerou (Harvard University)H-Index: 18
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Bronchopulmonary dysplasia remains one of the most common complication of prematurity, despite significant improvements in perinatal care. Functional modeling of human lung development and disease, like BPD, is limited by our ability to access the lung and to maintain relevant progenitor cell populations in culture. We supplemented Rho/SMAD signaling inhibition with mTOR inhibition to generate epithelial basal cell-like cell lines from tracheal aspirates of neonates. Single-cell RNA-sequencing c...
5 CitationsSource
#1Jie Xu (UM: University of Michigan)H-Index: 19
#2Alessandra Livraghi-Butrico (UNC: University of North Carolina at Chapel Hill)H-Index: 15
Last. Fei SunH-Index: 9
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Existing animal models of cystic fibrosis (CF) have provided key insights into CF pathogenesis but have been limited by short life spans, absence of key phenotypes, and/or high maintenance costs. Here, we report the CRISPR/Cas9-mediated generation of CF rabbits, a model with a relatively long lifespan and affordable maintenance and care costs. CF rabbits supplemented solely with oral osmotic laxative had a median survival of ~ 40 days and died of gastrointestinal disease, but therapeutic regimen...
5 CitationsSource
#1Yuan Hao (Brigham and Women's Hospital)H-Index: 4
#2Samuel BatesH-Index: 1
Last. Xiaobo Zhou (Brigham and Women's Hospital)H-Index: 58
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RATIONALE Genetic association studies have identified rs2076295 in association with idiopathic pulmonary fibrosis (IPF). We hypothesized rs2076295 is the functional variant regulating desmoplakin (DSP) expression in human bronchial epithelial cells, and DSP regulates extracellular matrix-related gene expression and cell migration, relevant to IPF development. OBJECTIVE To determine whether rs2076295 regulates DSP expression, and the function of DSP in airway epithelial cells. METHODS Using CRISP...
3 CitationsSource
#1Darin L. Wiesner (UW: University of Wisconsin-Madison)H-Index: 16
#2Richard M. Merkhofer (UW: University of Wisconsin-Madison)H-Index: 7
Last. Bruce S. Klein (UW: University of Wisconsin-Madison)H-Index: 59
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Summary Airway epithelium is the first body surface to contact inhaled irritants and report danger. Here, we report how epithelial cells recognize and respond to aeroallergen alkaline protease 1 (Alp1) of Aspergillus sp., because proteases are critical components of many allergens that provoke asthma. In a murine model, Alp1 elicits helper T (Th) cell-dependent lung eosinophilia that is initiated by the rapid response of bronchiolar club cells to Alp1. Alp1 damages bronchiolar cell junctions, wh...
11 CitationsSource
#1Michael B. Feldman (Harvard University)H-Index: 9
#1Michael B. Feldman (Harvard University)H-Index: 10
Last. Jatin M. Vyas (Harvard University)H-Index: 28
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Aspergillus fumigatus is a ubiquitous fungal pathogen capable of causing multiple pulmonary diseases including invasive aspergillosis, chronic necrotizing aspergillosis, fungal colonization, and allergic bronchopulmonary aspergillosis. Intact mucocilliary barrier function and early airway neutrophil responses are critical for clearing fungal conidia from the host airways prior to establishing disease. Following inhalation, Aspergillus conidia deposit in the small airways where they are likely to...
2 CitationsSource
#1Hongmei MouH-Index: 17