Wassim Abou-Kheir
American University of Beirut
CancerInternal medicineEndocrinologyPathologyNeuroscienceChemistryProgenitor cellPTENMetastasisProstate cancerAdenocarcinomaStem cellPopulationNeurogenesisCancer researchCancer stem cellMedicineCell cultureBiologyCell biology
100Publications
21H-index
1,484Citations
Publications 99
Newest
#1Malak FouaniH-Index: 1
#2Marc FakhouryH-Index: 16
Last. Nada B. LawandH-Index: 15
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Central nervous system tumors and three-dimensional cell biology: Current and future perspectives in modeling
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#1Joseph E. Azar (AUB: American University of Beirut)H-Index: 3
#2Hisham F. Bahmad (AUB: American University of Beirut)H-Index: 13
Last. Wassim Abou-Kheir (AUB: American University of Beirut)H-Index: 21
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Organoids represent one of the most important advancements in the field of stem cells during the past decade. They are three-dimensional in vitro culturing models that originate from self-organizing stem cells and can mimic the in vivo structural and functional specificities of body organs. Organoids have been established from multiple adult tissues as well as pluripotent stem cells and have recently become a powerful tool for studying development and diseases in vitro, drug screening, and host-...
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#1Samar Al Bitar (AUB: American University of Beirut)H-Index: 2
#2Farah Ballout (AUB: American University of Beirut)H-Index: 5
Last. Hala Gali-Muhtasib (AUB: American University of Beirut)H-Index: 32
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Introduction: Radiotherapy is a standard neo-adjuvant therapy for cancer treatment, the success of which is limited by the resistance of cancer stem cells (CSCs) to therapy in addition to the deleterious effects of ionizing radiation (IR) to surrounding normal tissues. Despite the anticancer efficacy of combining IR with standard chemotherapeutic drugs, such treatments have shown great toxicity to normal cells. Thus, recent therapeutic strategies have aimed to combine IR with natural compounds t...
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#1Hisham F. Bahmad (Mount Sinai Hospital)H-Index: 13
#2Mohamad K. Elajami (Mount Sinai Hospital)H-Index: 3
Last. Wassim Abou-Kheir (AUB: American University of Beirut)H-Index: 21
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Stem cells are undifferentiated cells with the ability to proliferate and convert to different types of differentiated cells that make up the various tissues and organs in the body. They exist both in embryos as pluripotent stem cells that can differentiate into the three germ layers and as multipotent or unipotent stem cells in adult tissues to aid in repair and homeostasis. Perturbations in these cells' normal functions can give rise to a wide variety of diseases. In this review, we discuss th...
5 CitationsSource
#1Farah Chamaa (KAUST: King Abdullah University of Science and Technology)H-Index: 10
#2Batoul Darwish (AUB: American University of Beirut)H-Index: 4
Last. Wassim Abou-Kheir (AUB: American University of Beirut)H-Index: 21
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Abstract Deep brain stimulation (DBS) has shown positive clinical results in neurodegenerative diseases. Previous work from our group showed that a single session of DBS to the anteromedial thalamic nucleus (AMN) in awake rats, increased proliferation of stem/progenitor cells in the dentate gyrus (DG) of the hippocampus. We thought to examine the effect of single versus multiple sessions of DBS to the AMN in modulating adult hippocampal neurogenesis. Rats received unilateral single session, mult...
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Prostate cancer (PCa) is by far the most commonly diagnosed cancer in men worldwide. Despite sensitivity to androgen deprivation, patients with advanced disease eventually develop resistance to therapy and may die of metastatic castration-resistant prostate cancer (mCRPC). A key challenge in the management of PCa is the clinical heterogeneity that is hard to predict using existing biomarkers. Defining molecular biomarkers for PCa that can reliably aid in diagnosis and distinguishing patients who...
4 CitationsSource
#1Muhieddine Labban (AUB: American University of Beirut)H-Index: 2
#2J. Najdi (AUB: American University of Beirut)
Last. Albert El-Hajj (AUB: American University of Beirut)H-Index: 3
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BACKGROUND Bladder cancer is the ninth most common cancer worldwide, and the third most common cancer in Lebanon. Immunohistochemistry (IHC) has been used to stratify muscle-invasive bladder cancer (MIBC) into different subtypes. However, to our knowledge, there exists no study that investigates the use of this low-cost technique to predict prognosis in bladder cancer patients in our region. AIM To examine the feasibility of low-cost triple-marker IHC assessment for MIBC subtyping in order to pr...
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#1Jolie Bou-Gharios (AUB: American University of Beirut)H-Index: 2
#2Sahar Assi (AUB: American University of Beirut)H-Index: 4
Last. Wassim Abou-Kheir (AUB: American University of Beirut)H-Index: 21
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1 CitationsSource
#1Hisham F. Bahmad (AUB: American University of Beirut)H-Index: 13
#2Reda M. Chalhoub (AUB: American University of Beirut)H-Index: 6
Last. Wassim Abou-Kheir (AUB: American University of Beirut)H-Index: 21
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Neuroblastoma (NB) is the most frequently diagnosed extracranial solid tumor among the pediatric population. It is an embryonic tumor with high relapse rates pertaining to the presence of dormant slowly dividing cancer stem cells (CSC) within the tumor bulk that are responsible for therapy resistance. Therefore, there is a dire need to develop new therapeutic approaches that specifically target NB CSCs. Glycogen synthase kinase (GSK)-3β is a serine/threonine kinase that represents a common signa...
5 CitationsSource