Alexandra V. Chatzikonstantinou
University of Ioannina
Nuclear chemistryIonic liquidSolubilityFourier transform infrared spectroscopyCatalysisBioreactorNanotechnologyX-ray photoelectron spectroscopyOrganic chemistryCovalent bondEnzymeBiochemical engineeringChemistryBiocatalysisMaterials scienceCombinatorial chemistryHydroxytyrosolOleuropeinNatural productCandida antarcticaLipaseBioconversionQuercetinBiotransformationMoleculeImmobilized enzymeComputer scienceMolecular dynamicsRegioselectivityNuclear magnetic resonance spectroscopyDrug discovery
17Publications
5H-index
111Citations
Publications 16
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#1Elena Gkantzou (UoI: University of Ioannina)H-Index: 3
#2Katerina Govatsi (FORTH: Foundation for Research & Technology – Hellas)
Last. Haralambos Stamatis (UoI: University of Ioannina)H-Index: 35
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#1Elena Gkantzou (UoI: University of Ioannina)H-Index: 3
#2Alexandra V. Chatzikonstantinou (UoI: University of Ioannina)H-Index: 5
Last. Haralambos Stamatis (UoI: University of Ioannina)H-Index: 35
view all 6 authors...
The ever-growing demand for cost-effective and innocuous biocatalytic transformations has prompted the rational design and development of robust biocatalytic tools. Enzyme immobilization technology lies in the formation of cooperative interactions between the tailored surface of the support and the enzyme of choice, which result in the fabrication of tremendous biocatalytic tools with desirable properties, complying with the current demands even on an industrial level. Different nanoscale materi...
3 CitationsSource
In this work, hybrid zinc oxide–iron oxide (ZnOFe) magnetic nanoparticles were synthesized employing Olea europaea leaf aqueous extract as a reducing/chelating and capping medium. The resulting magnetic nanoparticles were characterized by basic spectroscopic and microscopic techniques, namely, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), fourier-transform infrared (FTIR) and atomic force microscopy (AFM), exhibiting a spherical shape, average size of 15–17 nm, and a functiona...
1 CitationsSource
#1Antonios Kouloumpis (UoI: University of Ioannina)H-Index: 12
#2Alexandra V. Chatzikonstantinou (UoI: University of Ioannina)H-Index: 5
Last. Petra Rudolf (UG: University of Groningen)H-Index: 60
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Germanane (GeH), a graphane analogue, has attracted significant interest because of its optoelectronic properties; however, the environmental and biological effects of GeH have scarcely been invest...
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#1Alexandra V. Chatzikonstantinou (UoI: University of Ioannina)H-Index: 5
#2Angeliki C. Polydera (UoI: University of Ioannina)H-Index: 8
Last. Haralambos Stamatis (UoI: University of Ioannina)H-Index: 35
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Abstract The preparation, characterization and application of a novel robust nanobiocatalyst, developed through the covalent binding of lipase B from Pseudozyma antarctica on magnetic hierarchically porous carbon materials (HPCFe), is reported. The nanobiocatalyst was characterized by combination of spectroscopic and microscopic techniques. Structural and catalytic characterization indicates that HPCFe nanostructures create a microenvironment which stabilizes the structure of the immobilized enz...
5 CitationsSource
#1Alexandra V. Chatzikonstantinou (UoI: University of Ioannina)H-Index: 5
#2Antonis D. Tsiailanis (UoI: University of Ioannina)H-Index: 3
Last. Andreas G. Tzakos (UoI: University of Ioannina)H-Index: 30
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Abstract Enzymes are pliable systems and core cellular components allowing the performance of several processes. They can also be utilized as “green” synthetic factories to generate bioactive therapeutic, diagnostic or theranostic compounds. Methods to enable the mapping of enzyme substrates as well as the understanding of the interactions of the formed products with target proteins could be of importance. This chapter describes the utilization of the “NMR tube bioreactor” method. This method, c...
1 CitationsSource
#1Alexandra V. Chatzikonstantinou (UoI: University of Ioannina)H-Index: 5
#2Elena Gkantzou (UoI: University of Ioannina)H-Index: 3
Last. Haralambos Stamatis (UoI: University of Ioannina)H-Index: 35
view all 10 authors...
In the present study, we developed novel β-glucosidase-based nano-biocatalysts for the bioconversion of oleuropein to hydroxytyrosol. Using non-covalent or covalent immobilization approaches, β-glucosidases from almonds and Thermotoga maritima were attached for the first time on oxidized and non-oxidized porous carbon cuboids (PCC). Various methods were used for the characterization of the bio-nanoconjugates, such as Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscop...
8 CitationsSource
#1Alexandra V. Chatzikonstantinou (UoI: University of Ioannina)H-Index: 5
#2Maria V. Chatziathanasiadou (UoI: University of Ioannina)H-Index: 9
Last. Andreas G. Tzakos (UoI: University of Ioannina)H-Index: 30
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Abstract Background Natural products offer a wide range of biological activities, but they are not easily integrated in the drug discovery pipeline, because of their inherent scaffold intricacy and the associated complexity in their synthetic chemistry. Enzymes may be used to perform regioselective and stereoselective incorporation of functional groups in the natural product core, avoiding harsh reaction conditions, several protection/deprotection and purification steps. Methods Herein, we devel...
7 CitationsSource
#1Alexandra V. Chatzikonstantinou (UoI: University of Ioannina)H-Index: 5
#2Elena Gkantzou (UoI: University of Ioannina)H-Index: 3
Last. Haralambos Stamatis (UoI: University of Ioannina)H-Index: 35
view all 5 authors...
Abstract This chapter deals with the use of functionalized derivatives of graphene oxide as nanoscaffolds for the immobilization and stabilization of laccase from Trametes versicolor. Covalent and noncovalent immobilization approaches are described, while a novel method for the development of laccase-based multilayer nanoassemblies is also presented. Various biochemical, spectroscopic, and microscopic techniques were applied to characterize the nanobiocatalytic systems in respect to their micros...
3 CitationsSource