David C. Whitcomb
University of Pittsburgh
Internal medicineEndocrinologySurgeryPathologyIntensive care medicinePancreatitisHereditary pancreatitisAcute pancreatitisPancreatic diseasePancreasDiseasePancreatic cancerTrypsinogenIn patientGeneticsDiabetes mellitusBioinformaticsMedicineBiologyGastroenterology
Publications 609
#1David C. WhitcombH-Index: 89
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#1Christie Y. Jeon (UCLA: University of California, Los Angeles)H-Index: 26
#2Robert G. Feldman (University of Pittsburgh)H-Index: 48
Last. Adam Slivka (University of Pittsburgh)H-Index: 61
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BACKGROUND/OBJECTIVE Smoking prevalence in patients with chronic pancreatitis [CP] is high. We aimed to understand lifetime history of smoking and cohort trends in CP patients to inform effective strategies for smoking cessation. METHOD Data on 317 CP patients from the North American Pancreatitis Study 2 [NAPS2] Continuation and Validation Study and the NAPS2 Ancillary Study were analyzed. Smoking history was assessed for each phase of life from the onset of smoking to study enrollment. Data on ...
#1Christopher J. Langmead (CMU: Carnegie Mellon University)H-Index: 21
#2Peter Lee (HUP: Hospital of the University of Pennsylvania)H-Index: 9
Last. Georgios I. Papachristou (University of Pittsburgh)H-Index: 49
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INTRODUCTION Existing laboratory markers and clinical scoring systems have shown suboptimal accuracies for early prediction of persistent organ failure (POF) in acute pancreatitis (AP). We used information theory and machine learning to select the best-performing panel of circulating cytokines for predicting POF early in the disease course and performed verification of the cytokine panel's prognostic accuracy in an independent AP cohort. METHODS The derivation cohort included 60 subjects with AP...
#1Jorge D. MachicadoH-Index: 13
#2Rawad MounzerH-Index: 15
Last. Georgios I. PapachristouH-Index: 49
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#1Ellyn K. Dunbar (University of Pittsburgh)H-Index: 1
#2Jami L. Saloman (University of Pittsburgh)H-Index: 14
Last. David C. Whitcomb (University of Pittsburgh)H-Index: 89
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Pain is the most distressing and disruptive feature of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) resulting in low quality of life (QOL) and disabilities. There is no single, characteristic pain pattern in patients with RAP and CP. Abdominal imaging features of CP accurately reflect morphologic features but they do not correlate with pain. Pain is the major driver of poor quality of life (QOL) and it is the constant pain, rather than intermittent pain that drives poor QOL. ...
#1Rhonda M. Brand (University of Pittsburgh)H-Index: 20
#2Beverley A. Moore (University of Pittsburgh)H-Index: 9
Last. Ian McGowan (University of Pittsburgh)H-Index: 24
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Introduction: Poor translatability of animal disease models has hampered development of new inflammatory bowel disorders (IBD) therapeutics. We describe a preclinical, ex vivo system using freshly ...
#1Pedram Paragomi (University of Pittsburgh)H-Index: 11
#2Marie Tuft (University of Pittsburgh)H-Index: 4
Last. Georgios I. Papachristou (OSU: Ohio State University)H-Index: 49
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BACKGROUND AND AIM The primary aim was to validate the Pancreatitis Activity Scoring System (PASS) in a multicenter prospectively ascertained acute pancreatitis (AP) cohort. Second, we investigated the association of early PASS trajectories with disease severity and length of hospital stay (LOS). METHODS Data were prospectively collected through the APPRENTICE consortium (2015-2018). AP severity was categorized based on revised Atlanta classification. Delta PASS (ΔPASS) was calculated by subtrac...
#1Kishore Vipperla (University of Pittsburgh)H-Index: 9
#2Allison Kanakis (University of Pittsburgh)H-Index: 1
Last. Dhiraj Yadav (University of Pittsburgh)H-Index: 52
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Abstract Objectives Pain burn-out during the course of chronic pancreatitis (CP), proposed in the 1980s, remains controversial, and has clinical implications. We aimed to describe the natural course of pain in a well-characterized cohort. Methods We constructed the clinical course of 279 C P patients enrolled from 2000 to 2014 in the North American Pancreatitis Studies from UPMC by retrospectively reviewing their medical records (median observation period, 12.4 years). We assessed abdominal pain...
#1Zobeida Cruz-Monserrate (The Ohio State University Wexner Medical Center)H-Index: 21
#2Kristyn Gumpper (The Ohio State University Wexner Medical Center)H-Index: 9
Last. Darwin L. Conwell (The Ohio State University Wexner Medical Center)H-Index: 53
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Abstract Background Chronic pancreatitis (CP) does not have diagnostic or prognostic biomarkers. CP is the end stage of a progressive inflammatory syndrome that is diagnosed at late stages by morphologic features. To diagnose earlier stages of the disease, a new mechanistic definition was established based on identifying underlying pathogenic processes and biomarker evidence of disease activity and stage. Although multiple risk factors are known, the corresponding biomarkers needed to make a hig...
INTRODUCTION Studies evaluating the natural history of exocrine pancreatic dysfunction (EPD) after acute pancreatitis (AP) are sparse. This study aims to assess incidence and predictors of weight loss and gastrointestinal (GI) symptoms suggestive of EPD 12 months after an AP episode. METHODS Patients enrolled in the Pancreatitis-associated Risk of Organ Failure Study at the time of an AP episode were included. Weight and GI symptom data were prospectively collected by self-report at enrollment a...