Paola Mura
University of Florence
Drug carrierNuclear chemistryDissolution testingSolubilityOrganic chemistryAqueous solutionChemistryMaterials scienceNaproxenInclusion compoundCyclodextrinChitosanDrugDifferential scanning calorimetryChemical engineeringChromatographyPermeationAmorphous solidDosage formDissolution
224Publications
50H-index
6,766Citations
Publications 221
Newest
#1Paola MuraH-Index: 50
Last. Marzia CirriH-Index: 33
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The aim of this study was the optimization of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in terms of physicochemical and biopharmaceutical properties, to develop effective and stable aqueous liquid formulations of hydrochlorothiazide, suitable for paediatric therapy, overcoming its low-solubility and poor-stability problems. Based on solubility studies, Precirol® ATO5 and Transcutol® HP were used as solid and liquid lipids, respectively. The effect of different surfa...
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#1Marzia Cirri (UniFI: University of Florence)H-Index: 33
#2Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
Last. Paola Mura (UniFI: University of Florence)H-Index: 50
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Abstract Metronidazole is the drug of choice in the treatment of bacterial vaginosis, but the oral therapy can induce several collateral effects. Aim of this work was the development of a vaginal multiparticulate system loaded with metronidazole able to improve its residence time allowing a complete drug release. Several kinds of MS were prepared using chitosan dissolved in different organic acids or alginate coated with chitosan. FTIR and DSC analyses were performed to study the interactions be...
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#1Marzia Cirri (UniFI: University of Florence)H-Index: 33
#2Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
Last. Paola Mura (UniFI: University of Florence)H-Index: 50
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Abstract Hydrochlorothiazide (HCT) is widely used in pediatrics for hypertension management. Due to the lack of pediatric commercial forms, community or hospital pharmacies generally prepare HCT extemporaneous pediatric suspensions by dispersing in water a portion of a crushed tablet or the drug powder; however, any dose or stability control is usually done on these preparations. Obtaining stable HCT solutions is very challenging, due to its low water-solubility and pH-dependent degradation. The...
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#1Marzia Cirri (UniFI: University of Florence)H-Index: 33
#2Paola Mura (UniFI: University of Florence)H-Index: 50
Last. Letizia Brunetti (UniFI: University of Florence)H-Index: 1
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The aim of this work was to evaluate the effectiveness of mesoporous clays or silicas to develop fast-dissolving glyburide tablets based on a liquisolid approach. Selected clay (Neusilin®US2) and silica (Aeroperl®300) allowed preparation of innovative drug liquisolid systems containing dimethylacetamide or 2-pyrrolidone as drug solvents, without using coating materials which are necessary in conventional systems. The obtained liquisolid powders were characterized for solid-state properties, flow...
2 CitationsSource
#1Paola Mura (UniFI: University of Florence)H-Index: 50
Abstract Complexation with cyclodextrins (CDs) has been widely and successfully used in pharmaceutical field, mainly for enhancing solubility, stability and bioavailability of a variety of drugs. However, some important drawbacks, including rapid removal from the bloodstream after in vivo administration, or possible replacement, in biological media, of the entrapped drug moieties by other molecules with higher affinity for the CD cavity, can limit the CDs effectiveness as drug carriers. This rev...
6 CitationsSource
#1Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
#2Patrizia Rossi (UniFI: University of Florence)H-Index: 22
Last. Paola Mura (UniFI: University of Florence)H-Index: 50
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Abstract Flufenamic acid is a nonsteroidal anti-inflammatory drug characterized by a low solubility and a variable oral bioavailability. Flufenamic acid is present in the commercial products in two polymorphic enantiotropic forms (Form I and III). Bioinequivalence was observed for commercial solid dosage forms due to the different dissolution rate of batches. Aim of this work is the full characterization of the solid state properties of flufenamic acid in order to evidence reasons of its variabl...
3 CitationsSource
#1Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
#2Marzia Cirri (UniFI: University of Florence)H-Index: 33
Last. Paola Mura (UniFI: University of Florence)H-Index: 50
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Hydrochlorothiazide (HCT), a Biopharmaceutical Classification System (BCS) class IV drug, is characterized by low solubility and permeability, that negatively affect its oral bioavailability, reducing its therapeutic efficacy. The combined use of cyclodextrins (CDs) and nanoclays (NCs) recently proved to be a successful strategy in developing delivery systems able to merge the potential benefits of both carriers. In this work, several binary systems of CDs or NCs with the drug were obtained, usi...
5 CitationsSource
#1Paola Mura (UniFI: University of Florence)H-Index: 50
#2Maurizio ValleriH-Index: 6
Last. Natascia Mennini (UniFI: University of Florence)H-Index: 24
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Abstract The performance of a series of inorganic salts as direct compression excipients was systematically evaluated. The physical-chemical and technological properties of the different salts were investigated in terms of crystalline/amorphous state, morphology, granulometry, apparent/tapped density, specific surface area, flowability, compressibility, dilution and distribution coefficients. To achieve a comprehensive evaluation of the performance of the different salts, the data obtained by th...
1 CitationsSource
#1Paola Mura (UniFI: University of Florence)H-Index: 50
#2Maurizio ValleriH-Index: 6
Last. Marzia Cirri (UniFI: University of Florence)H-Index: 33
view all 5 authors...
Abstract This work evaluated the suitability of various mesoporous silicas as carriers for developing an oral formulation endowed with improved dissolution properties of glibenclamide, hypoglycemic agent poorly water-soluble. The different silicas were examined for solid-state, morphology, and technological and physical-chemical properties (granulometry, specific surface area, wettability, water content, water activity, apparent density, flowability, compactability). A pairwise comparison allowe...
8 CitationsSource