Jiri Vejvoda
Charles University in Prague
Troponin IInternal medicineSurgeryCardiologyRandomized controlled trialIntensive care medicinePlacebo-controlled studyStatinHeparinAspirinAcute coronary syndromeUnstable anginaCholesterolFluvastatinCerivastatinC-reactive proteinIn patientMyocardial infarctionClinical trialMedicine
10Publications
6H-index
131Citations
Publications 10
Newest
#1Jiří BonaventuraH-Index: 2
#2David AlanH-Index: 6
Last. Josef VeselkaH-Index: 23
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In spite of many years of development and implementation of pre-hospital advanced life support programmes, the survival rate of out-of-hospital cardiac arrest (OHCA) used to be very poor. Neurologic injury from cerebral hypoxia is the most common cause of death in patients with OHCA. In the past two decades, post-resuscitation care has developed many new concepts aimed at improving the neurological outcome and survival rate of patients after cardiac arrest. Systematic post-cardiac arrest care af...
8 CitationsSource
Selenium (Se) is an essential trace element with antioxidant function. The aim of the present study was to estimate the alterations of Se serum level during the acute phase of myocardial infarction and its relation to biomarkers of myocardial necrosis. Serum Se levels were measured at admission and after 24 h in 60 consecutive patients with acute coronary syndrome (both with and without ST elevation). Troponin I (TnI) was assessed at admission and then twice daily for 3 days; patients with norma...
19 CitationsSource
#1Petr OstadalH-Index: 19
#2David AlanH-Index: 6
Last. Jana Cepova (Charles University in Prague)H-Index: 7
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Background Statins have been proved to be effective in reduction of mortality and morbidity when started in the early secondary prevention in stabilized patients after acute coronary syndrome (ACS). The safety and efficacy of statin administration directly in the first-line therapy in unstable ACS patients is not clear. The aim of our study was, therefore, to assess the effect of statin treatment initiated immediately at hospital admission of patients with ACS.
18 CitationsSource
#1Petr Hájek (Charles University in Prague)H-Index: 15
#2David Alan (Charles University in Prague)H-Index: 6
Last. Josef Veselka (Charles University in Prague)H-Index: 23
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A left main coronary artery thrombosis is a life-threatening condition demanding immediate therapeutic management. Traditional treatment options include thrombolysis, percutaneous coronary intervention (PCI) with stenting or cardiac bypass surgery. The number of reported cases in which aspiration thrombectomy has been used is limited. Indications for this therapeutic approach are determined by coronary anatomy, clinical stability, and hemodynamic condition of the patient. We present the case of ...
7 CitationsSource
#1Petr Ostadal (Charles University in Prague)H-Index: 19
#2David AlanH-Index: 6
Last. Andreas KrügerH-Index: 18
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Acute coronary syndrome (ACS) is a pathological condition caused by erosion or disruption of unstable coronary plaques, leading to subsequent activation of a coagulation cascade, platelet adhesion and aggregation, fibrin deposition and ultimately to the formation of a thrombus, obstructing the coronary artery. It is, therefore, apparent that the optimal therapeutic approach should include antiplatelet and anticoagulant agents. Low-molecular-weight heparins (LMWHs) have been repeatedly shown to b...
4 Citations
#1Petr Ostadal (Charles University in Prague)H-Index: 19
#2David Alan (Charles University in Prague)H-Index: 6
Last. Æ Jan Vojacek (Charles University in Prague)H-Index: 1
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It is widely assumed that acute benefit of statin therapy is mediated especially by non-lipid effects. The immediate influence of statins on lipid levels in patients with acute coronary syndrome (ACS) is, however, not clear. A total of 64 consecutive patients with ACS were randomized at admission to fluvastatin 80 mg (Group 1, N = 32) or standard therapy without statin (Group 2, N = 32). The levels of total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein c...
5 CitationsSource
#1Petr Ostadal (Charles University in Prague)H-Index: 19
#2David Alan (Charles University in Prague)H-Index: 6
Last. Jana Cepova (Charles University in Prague)H-Index: 7
view all 4 authors...
Source
#1Petr Ostadal (Charles University in Prague)H-Index: 19
#2David Alan (Charles University in Prague)H-Index: 6
Last. Jana Cepova (Charles University in Prague)H-Index: 7
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Background: Activation of inflammatory pathways plays an important contributory role in coronary plaque instability and subsequent rupture, which can lead to the development of acute coronary syndrome (ACS). Elevated levels of serum inflammatory markers such as C-reactive protein (CRP) represent independent risk factors for further cardiovascular events. Recent evidence indicates that in addition to lowering cholesterol levels, statins also decrease levels of inflammatory markers. Previous contr...
21 CitationsSource
#1Petr Ostadal (Charles University in Prague)H-Index: 19
#2David AlanH-Index: 6
Last. Jiri VejvodaH-Index: 6
view all 3 authors...
Statins are cholesterol-lowering drugs, highly effective in the primary and secondary prevention of coronary artery disease. It has been found, however, that statins also have nonlipid effects; they can influence different pathways, which have been described to participate in the pathogenesis of acute coronary syndrome (ACS). Inflammation or decreased production of nitric oxide are obvious targets for statin therapy. Recently, several large clinical trials have been published, showing safety and...
3 Citations
#1Petr Ostadal (Charles University in Prague)H-Index: 19
#2David Alan (Charles University in Prague)H-Index: 6
Last. Jan Vojáček (Charles University in Prague)H-Index: 16
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The aim of our study was to evaluate whether a single dose of cerivastatin at the time of admission of patients with unstable angina pectoris (UAP) or non-Q-wave myocardial infarction (NQMI) can influence the serum level of C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) 24 h later. Forty-four patients with rest chest pain and subendocardial ischemia on ECG were randomized to receive cerivastatin 0.3 mg at the time of admission (group C+) to standard therapy or to remain ...
48 CitationsSource