Napoleone Ferrara
University of California, San Diego
Vascular endothelial growth factor CCancerEndothelial stem cellInternal medicineEndocrinologyPathologyVascular endothelial growth factor AVascular endothelial growth factor BMolecular biologyReceptorChemistryImmunologyGrowth factorEndotheliumVascular endothelial growth factorNeovascularizationAngiogenesisCancer researchMedicineBiologyCell biology
Publications 362
#1Claire E. Lewis (University of Sheffield)H-Index: 82
#2Napoleone Ferrara (Genentech)H-Index: 179
In this issue of Cancer Cell , Mazzieri, Pucci, and colleagues describe the marked effects of inhibiting the proangiogenic cytokine, Angiopoietin-2, on tumor angiogenesis and progression in spontaneous tumor models, as well as the proangiogenic functions of TIE2-expressing macrophages.
17 CitationsSource
Priming of the organ-specific premetastatic sites is thought to be an important yet incompletely understood step during metastasis. In this study, we show that the metastatic tumors we examined overexpress granulocyte-colony stimulating factor (G-CSF), which expands and mobilizes Ly6G+Ly6C+ granulocytes and facilitates their subsequent homing at distant organs even before the arrival of tumor cells. Moreover, G-CSF–mobilized Ly6G+Ly6C+ cells produce the Bv8 protein, which has been implicated in ...
414 CitationsSource
#1Ningxia LuH-Index: 5
#2Debra T. CloptonH-Index: 11
Last. Andrea S. CuppH-Index: 25
view all 7 authors...
Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy
178 CitationsSource
#1Benjamin Drogat (UGent: Ghent University)H-Index: 10
#2Joanna Kalucka (UGent: Ghent University)H-Index: 1
Last. Jody J. Haigh (UGent: Ghent University)H-Index: 40
view all 17 authors...
To determine the role of vascular endothelial growth factor (Vegf) in embryonic erythroid development we have deleted or overexpressed Vegf specifically in the erythroid lineage using the EpoR-iCre transgenic line in combination with Cre/loxP conditional gain and loss of function Vegf alleles. ROSA26 promoter-based expression of the Vegf164 isoform in the early erythroid lineage resulted in a differentiation block of primitive erythroid progenitor (EryP) development and a partial block in defini...
20 CitationsSource
#1Andrew Scott (UCL Institute of Ophthalmology)H-Index: 1
#1Andrew C. Scott (UCL Institute of Ophthalmology)H-Index: 64
Last. Marcus Fruttiger (UCL Institute of Ophthalmology)H-Index: 55
view all 8 authors...
Vascular endothelial growth factor (VEGF) plays a critical role in normal development as well as retinal vasculature disease. During retinal vascularization, VEGF is most strongly expressed by not yet vascularized retinal astrocytes, but also by retinal astrocytes within the developing vascular plexus, suggesting a role for retinal astrocyte-derived VEGF in angiogenesis and vessel network maturation. To test the role of astrocyte-derived VEGF, we used Cre-lox technology in mice to delete VEGF in...
132 CitationsSource
#1Alicia S. Chung (Genentech)H-Index: 8
#2John K. Lee (Genentech)H-Index: 17
Last. Napoleone Ferrara (Genentech)H-Index: 179
view all 3 authors...
The cardiovascular system develops and matures through two tightly regulated processes: vasculogenesis and angiogenesis. This Opinion article discusses the parallels and differences in the angiogenic process under either a physiological or a pathological state, especially tumorigenesis.
642 CitationsSource
#1Ling Luo (UofU: University of Utah)H-Index: 16
#2H. Uehara (UofU: University of Utah)H-Index: 2
Last. B. K. Ambati (UofU: University of Utah)H-Index: 4
view all 10 authors...
#1Yeung Yik Andy (Genentech)H-Index: 2
#2Xiumin WuH-Index: 28
Last. Henry B. LowmanH-Index: 42
view all 12 authors...
Bevacizumab [Avastin; anti–vascular endothelial growth factor (VEGF) antibody] is an antiangiogenic IgG approved for treating patients with certain types of colon, breast, and lung cancer. In these indications, bevacizumab is administered every 2 to 3 weeks, prompting us to study ways to reduce the frequency of administration. Increasing affinity to neonatal Fc receptor (FcRn) may extend the pharmacokinetic half-life of an antibody, but the quantitative effect of FcRn affinity on clearance has n...
116 CitationsSource
#1Carlos Bais (Genentech)H-Index: 21
#2Xiumin Wu (Genentech)H-Index: 28
Last. Napoleone Ferrara (Genentech)H-Index: 179
view all 23 authors...
Summary It has been recently reported that treatment with an anti-placenta growth factor (PlGF) antibody inhibits metastasis and primary tumor growth. Here we show that, although anti-PlGF treatment inhibited wound healing, extravasation of B16F10 cells, and growth of a tumor engineered to overexpress the PlGF receptor (VEGFR-1), neutralization of PlGF using four novel blocking antibodies had no significant effect on tumor angiogenesis in 15 models. Also, genetic ablation of the tyrosine kinase ...
200 CitationsSource