Napoleone Ferrara
University of California, San Diego
Vascular endothelial growth factor CCancerEndothelial stem cellInternal medicineEndocrinologyPathologyVascular endothelial growth factor AVascular endothelial growth factor BMolecular biologyReceptorChemistryImmunologyGrowth factorEndotheliumVascular endothelial growth factorNeovascularizationAngiogenesisCancer researchMedicineBiologyCell biology
Publications 362
#1Junji Moriya (UCSD: University of California, San Diego)H-Index: 3
#2Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
Inhibition of the vascular endothelial growth factor (VEGF)–VEGF receptor 2 (VEGFR2) signaling axis may play a role in endothelial dysfunction and serious vascular complications associated with diabetes. In this issue, Warren et al . identified a ligand-independent, receptor tyrosine kinase–independent VEGFR2 signaling pathway that is responsible for impaired responses to VEGF in diabetic endothelial cells. Reactive oxygen species (ROS) resulting from the hyperglycemic status promoted activation...
8 CitationsSource
#1Ningxia LuH-Index: 5
#2Kevin M. SargentH-Index: 5
Last. Andrea S. CuppH-Index: 25
view all 10 authors...
Vascular endothelial growth factor A (VEGFA) isoform treatment has been demonstrated to alter spermatogonial stem cell homeostasis. Therefore, we generated pDmrt1-Cre;Vegfa−/− (knockout, KO) mice by crossing pDmrt1-Cre mice to floxed Vegfa mice to test whether loss of all VEGFA isoforms in Sertoli and germ cells would impair spermatogenesis. When first mated, KO males took 14 days longer to get control females pregnant (P < .02) and tended to take longer for all subsequent parturition intervals ...
29 CitationsSource
#1Minah Kim (KAIST)H-Index: 7
#2Hyeung Ju Park (KAIST)H-Index: 3
Last. Gou Young Koh (KAIST)H-Index: 70
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The features and regulation of uterine angiogenesis and vascular remodelling during pregnancy are poorly defined. Here we show that dynamic and variable decidual angiogenesis (sprouting, intussusception and networking), and active vigorous vascular remodelling such as enlargement and elongation of ‘vascular sinus folding’ (VSF) and mural cell drop-out occur distinctly in a spatiotemporal manner in the rapidly growing mouse uterus during early pregnancy — just after implantation but before placen...
86 CitationsSource
#1Alicia S. Chung (Genentech)H-Index: 8
#2Xiumin Wu (Genentech)H-Index: 28
Last. Napoleone FerraraH-Index: 179
view all 12 authors...
The efficacy of anti-angiogenic therapy for cancer could be improved if tumor resistance mechanisms were better understood. In this report, Napoleone Ferrara and his colleagues uncover a tumor resistance mechanism to VEGF-neutralizing antibodies triggered by IL-17, the hallmark cytokine of TH17 cells.
294 CitationsSource
#1Cuiling Zhong (Genentech)H-Index: 12
#2Jianyong Wang (Genentech)H-Index: 9
Last. Napoleone Ferrara (Genentech)H-Index: 179
view all 24 authors...
Purpose: Our goal was to develop a potent humanized antibody against mouse/human CXCL12. This report summarized its in vitro and in vivo activities. Experimental Design: Cell surface binding and cell migration assays were used to select neutralizing hamster antibodies, followed by testing in several animal models. Monoclonal antibody (mAb) 30D8 was selected for humanization based on its in vitro and in vivo activities. Results: 30D8, a hamster antibody against mouse and human CXCL12α, CXCL12β, a...
33 CitationsSource
#1Deepak Sampath (Genentech)H-Index: 44
#2Jason Oeh (Genentech)H-Index: 15
Last. Richard A.D. Carano (Genentech)H-Index: 53
view all 23 authors...
The phosphatidylinositol 3-kinase (PI3K) pathway is a central mediator of vascular endothelial growth factor (VEGF)-driven angiogenesis. The discovery of small molecule inhibitors that selectively target PI3K or PI3K and mammalian target of rapamycin (mTOR) provides an opportunity to pharmacologically determine the contribution of these key signaling nodes in VEGF-A-driven tumor angiogenesis in vivo. This study used an array of micro-vascular imaging techniques to monitor the antivascular effect...
25 CitationsSource
#1Matthew J. Brauer (Genentech)H-Index: 21
#2Guanglei Zhuang (Genentech)H-Index: 25
Last. Carlos Bais (Genentech)H-Index: 21
view all 30 authors...
Purpose: The aim of this study was to identify conserved pharmacodynamic and potential predictive biomarkers of response to anti-VEGF therapy using gene expression profiling in preclinical tumor models and in patients. Experimental Design: Surrogate markers of VEGF inhibition [VEGF-dependent genes or VEGF-dependent vasculature (VDV)] were identified by profiling gene expression changes induced in response to VEGF blockade in preclinical tumor models and in human biopsies from patients treated wi...
41 CitationsSource
#1Ling Luo (UofU: University of Utah)H-Index: 16
#2Hironori Uehara (UofU: University of Utah)H-Index: 14
Last. Balamurali K. Ambati (UofU: University of Utah)H-Index: 35
view all 35 authors...
Optimal phototransduction requires separation of the avascular photoreceptor layer from the adjacent vascularized inner retina and choroid. Breakdown of peri-photoreceptor vascular demarcation leads to retinal angiomatous proliferation or choroidal neovascularization, two variants of vascular invasion of the photoreceptor layer in age-related macular degeneration (AMD), the leading cause of irreversible blindness in industrialized nations. Here we show that sFLT-1, an endogenous inhibitor of vas...
61 CitationsSource
Background Platelet-derived growth factor-C (PDGF-C) is known to promote angiogenesis independently of vascular endothelial growth factor (VEGF), although its significance in postnatal angiogenesis in vivo remains poorly understood. Methods and Results We employed murine model of hind limb ischemia and found that expression of PDGF-C and its receptor PDGFR-alpha were markedly up-regulated in ischemic limbs. Treatment with a neutralizing antibody against PDGF-C significantly impaired blood flow r...
#1Guanglei Zhuang (Genentech)H-Index: 25
#2Napoleone Ferrara (Genentech)H-Index: 179
Last. Annalisa M. VanHook (American Association for the Advancement of Science)H-Index: 6
view all 3 authors...
This Podcast features an interview with Guanglei Zhuang and Napoleone Ferrara, authors of a Research Article that appears in the 16 April 2013 issue of Science Signaling . Zhuang and Ferrara discuss results from their analysis of the temporal dynamics of protein phosphorylation events downstream of vascular endothelial growth factor (VEGF) receptor activation. VEGFs are secreted growth factors that promote angiogenesis, and they promote growth of blood vessels during normal development, in wound...