Napoleone Ferrara
University of California, San Diego
Vascular endothelial growth factor CCancerEndothelial stem cellInternal medicineEndocrinologyPathologyVascular endothelial growth factor AVascular endothelial growth factor BMolecular biologyReceptorChemistryImmunologyGrowth factorEndotheliumVascular endothelial growth factorNeovascularizationAngiogenesisCancer researchMedicineBiologyCell biology
Publications 362
#1Kevin M. Sargent (NU: University of Nebraska–Lincoln)H-Index: 5
#2Ningxia Lu (NU: University of Nebraska–Lincoln)H-Index: 5
Last. Andrea S. Cupp (NU: University of Nebraska–Lincoln)H-Index: 25
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Because VEGFA has been implicated in follicle development, the objective of this study was to determine the effects of granulosa- and germ cell-specific VEGFA loss on ovarian morphogenesis, function, and female fertility. pDmrt1-Cre mice were mated to floxed VEGFA mice to develop granulosa-/germ cell-specific knockouts (pDmrt1-Cre;Vegfa-/-). The time from mating to first parturition was increased when pDmrt1-Cre;Vegfa-/- females were mated to control males (P = 0.0008) and tended to be longer fo...
10 CitationsSource
#1Kevin M. SargentH-Index: 5
#2Ningxia LuH-Index: 5
Last. Andrea S. CuppH-Index: 25
view all 8 authors...
#1Deepitha SelvarajH-Index: 5
#2Vijayan GangadharanH-Index: 10
Last. Rohini KunerH-Index: 55
view all 13 authors...
#1Guanglei Zhuang (Genentech)H-Index: 25
#2Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
The vascular endothelial growth factor (VEGF) family of ligands and receptors has been implicated in vascular development during embryogenesis. There is now a consensus that VEGF receptor signaling is also central to pathological angiogenesis associated with cancer, intraocular neovascular disorders, and other conditions. Advances in our understanding of the biology of VEGF pathway have led to the development and clinical applications of multiple VEGF-targeted therapies. A more comprehensive und...
#1Sylvaine Guérit (University of Bordeaux)H-Index: 4
#2Anne-Emilie Allain (University of Bordeaux)H-Index: 8
Last. Andreas Bikfalvi (University of Bordeaux)H-Index: 59
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Author(s): Guerit, Sylvaine; Allain, Anne-Emilie; Leon, Celine; Cazenave, William; Ferrara, Napoleone; Branchereau, Pascal; Bikfalvi, Andreas | Abstract: Although it has been documented that the nervous and the vascular systems share numerous analogies and are closely intermingled during development and pathological processes, interactions between the two systems are still poorly described. In this study, we investigated whether vascular endothelial growth factor (VEGF), which is a key regulator...
3 CitationsSource
#1Matija Snurdel (Harvard University)
#2Ana Batista (Harvard University)H-Index: 8
Last. Rakesh K. Jain (Harvard University)H-Index: 208
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Background: Medulloblastoma (MB) is the most common pediatric brain tumor and a heterogeneous disease. Several studies have characterized tumor genetic heterogeneity with the hope of identifying targets for personalized therapy. In fact, inhibitors of Sonic Hedgehog (Shh) - a developmental pathway aberrantly activated in a subset of MBs - are currently being evaluated. Unfortunately, mutations and potential developmental adverse effects in the pediatric population can limit these therapies. We p...
#1Jihong Yang (Genentech)H-Index: 2
#2Xiangdan WangH-Index: 4
Last. Sandeep YadavH-Index: 19
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The objectives of this study were to evaluate the relative binding and potencies of three inhibitors of vascular endothelial growth factor A (VEGF), used to treat neovascular age-related macular degeneration, and assess their relevance in the context of clinical outcome. Ranibizumab is a 48 kDa antigen binding fragment, which lacks a fragment crystallizable (Fc) region and is rapidly cleared from systemic circulation. Aflibercept, a 110 kDa fusion protein, and bevacizumab, a 150 kDa monoclonal a...
57 CitationsSource
#1Michal Milgrom-Hoffman (Weizmann Institute of Science)H-Index: 4
#2Inbal Michailovici (Weizmann Institute of Science)H-Index: 4
Last. Eldad Tzahor (Weizmann Institute of Science)H-Index: 30
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Cardiac and craniofacial developmental programs are intricately linked during early embryogenesis, which is also reflected by a high frequency of birth defects affecting both regions. The molecular nature of the crosstalk between mesoderm and neural crest progenitors and the involvement of endothelial cells within the cardio–craniofacial field are largely unclear. Here we show in the mouse that genetic ablation of vascular endothelial growth factor receptor 2 (Flk1) in the mesoderm results in ea...
14 CitationsSource
#1Junji Moriya (Genentech)H-Index: 3
#2Xiumin Wu (Genentech)H-Index: 28
Last. Napoleone Ferrara (Genentech)H-Index: 179
view all 6 authors...
Background Platelet-derived growth factor C (PDGF-C) has been reported to promote angiogenesis independently of vascular endothelial growth factor (VEGF), although its significance in postnatal angiogenesis in vivo remains poorly understood. VEGF has been employed as a major molecular tool to induce therapeutic angiogenesis. However, VEGF therapy is not very effective in models of cardiovascular diseases associated with diabetes, and the mechanisms of this phenomenon still remain to be elucidate...
17 CitationsSource
#1Jieqing Fan (Cincinnati Children's Hospital Medical Center)H-Index: 4
#1Jieqing Fan (UC: University of Cincinnati)H-Index: 4
Last. Richard A. Lang (UC: University of Cincinnati)H-Index: 2
view all 8 authors...
Angiogenesis defines the process in which new vessels grow from existing vessels. Using the mouse retina as a model system, we show that cysteine-rich motor neuron 1 (Crim1), a type I transmembrane protein, is highly expressed in angiogenic endothelial cells. Conditional deletion of the Crim1 gene in vascular endothelial cells (VECs) causes delayed vessel expansion and reduced vessel density. Based on known Vegfa binding by Crim1 and Crim1 expression in retinal vasculature, where angiogenesis is...
32 CitationsSource