Napoleone Ferrara
University of California, San Diego
Vascular endothelial growth factor CCancerEndothelial stem cellInternal medicineEndocrinologyPathologyVascular endothelial growth factor AVascular endothelial growth factor BMolecular biologyReceptorChemistryImmunologyGrowth factorEndotheliumVascular endothelial growth factorNeovascularizationAngiogenesisCancer researchMedicineBiologyCell biology
Publications 362
#1Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
See related article by Presta et al., [Cancer Res 1997;57:4593–99][1] . Visit the Cancer Research 75th Anniversary [timeline][2]. The highlighted article describes the engineering of a molecule that for the first time allowed testing the hypothesis that blocking VEGF-mediated angiogenesis may
1 CitationsSource
#1Nadja OsterbergH-Index: 8
#2Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
Last. Marcia MacheinH-Index: 20
view all 10 authors...
Glioblastomas are highly vascularized tumors with a prominent infiltration of macrophages/microglia whose role in promoting glioma growth, invasion, and angiogenesis has not been fully elucidated.The contribution of myeloid-derived vascular endothelial growth factor (VEGF) to glioma growth was analyzed in vivo in a syngeneic intracranial GL261 glioma model using a Cre/loxP system to knock out the expression of VEGF-A in CD11b + myeloid cells. Changes in angiogenesis-related gene expression profi...
18 CitationsSource
#1Mark Espina (UCSD: University of California, San Diego)H-Index: 3
#2Cheryl A. Arcinue (UCSD: University of California, San Diego)H-Index: 9
Last. William R. Freeman (UCSD: University of California, San Diego)H-Index: 82
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Aim To review the longitudinal changes of outer retinal tubulations (ORTs) in wet age-related macular degeneration (AMD) and their response to anti-vascular endothelial growth factor (VEGF) therapy by spectral-domain optical coherence tomography (SD-OCT), and to correlate these observations with disease activity, presence or absence of fluid, and patients’ demographics. Methods Retrospective study of wet AMD eyes treated with anti-VEGF agents and showing ORTs on SD-OCT, and the patients’ fellow ...
6 CitationsSource
#1Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
#2Anthony P. Adamis (Genentech)H-Index: 85
The targeting of vascular endothelial growth factor A (VEGFA), a crucial regulator of both normal and pathological angiogenesis, has revealed innovative therapeutic approaches in oncology and ophthalmology. The first VEGFA inhibitor, bevacizumab, was approved by the US Food and Drug Administration in 2004 for the first-line treatment of metastatic colorectal cancer, and the first VEGFA inhibitors in ophthalmology, pegaptanib and ranibizumab, were approved in 2004 and 2006, respectively. To mark ...
360 CitationsSource
#1Alexander Jais (MPG: Max Planck Society)H-Index: 13
#2Maite Solas (MPG: Max Planck Society)H-Index: 19
Last. Jens C. BrüningH-Index: 84
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High-fat diet (HFD) feeding induces rapid reprogramming of systemic metabolism. Here, we demonstrate that HFD feeding of mice downregulates glucose transporter (GLUT)-1 expression in blood-brain barrier (BBB) vascular endothelial cells (BECs) and reduces brain glucose uptake. Upon prolonged HFD feeding, GLUT1 expression is restored, which is paralleled by increased expression of vascular endothelial growth factor (VEGF) in macrophages at the BBB. In turn, inducible reduction of GLUT1 expression ...
100 CitationsSource
#1Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
I am honored and humbled to be one of the awardees of the 2014 A. Champalimaud Vision Award. I offer my heartfelt thanks to the Champalimaud Foundation President, Leonor Beleza, and to the Award Committee Members for this wonderful recognition. I feel especially fortunate to have had the opportunity to witness my scientific discoveries move from the bench to the clinic. Scientific discovery is hugely exciting, but the ability to translate that work into potentially helping someone lead a better ...
35 CitationsSource
#1Wei Liang (UCSD: University of California, San Diego)H-Index: 10
#2Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
Chronic inflammation fosters cancer development and progression and also modulates tumor responses to anticancer therapies. Neutrophils are key effector cells in innate immunity and are known to play a critical role in various inflammatory disorders. However, the functions of neutrophils in cancer pathogenesis have been largely neglected until recently and still remain poorly characterized compared with other immune cells in the tumor microenvironment. We highlight recent findings on the mechani...
136 CitationsSource
#1Deepitha Selvaraj (Heidelberg University)H-Index: 5
#2Vijayan Gangadharan (Heidelberg University)H-Index: 10
Last. Rohini Kuner (Molecular Medicine Partnership Unit)H-Index: 55
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Cancer pain is a debilitating disorder and a primary determinant of the poor quality of life. Here, we report a non-vascular role for ligands of the Vascular Endothelial Growth Factor (VEGF) family in cancer pain. Tumor-derived VEGF-A, PLGF-2, and VEGF-B augment pain sensitivity through selective activation of VEGF receptor 1 (VEGFR1) expressed in sensory neurons in human cancer and mouse models. Sensory-neuron-specific genetic deletion/silencing or local or systemic blockade of VEGFR1 prevented...
57 CitationsSource
#1Idit Eshkar-Oren (Weizmann Institute of Science)H-Index: 3
#2Sharon Krief (Weizmann Institute of Science)H-Index: 11
Last. Elazar Zelzer (Weizmann Institute of Science)H-Index: 31
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Blood vessels serve as key regulators of organogenesis by providing oxygen, nutrients and molecular signals. During limb development, programmed cell death (PCD) contributes to separation of the digits. Interestingly, prior to the onset of PCD, the autopod vasculature undergoes extensive patterning that results in high interdigital vascularity. Here, we show that in mice, the limb vasculature positively regulates interdigital PCD. In vivo , reduction in interdigital vessel number inhibited PCD, ...
10 CitationsSource
#1Junji Moriya (UCSD: University of California, San Diego)H-Index: 3
#2Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
Background Diabetes is a risk factor for the development of cardiovascular diseases with impaired angiogenesis. We have previously shown that platelet-derived growth factor C (PDGF-C) and its receptor, PDGF receptor α (PDGFR-α) were downregulated in ischemic limbs of diabetic mice, although the underlying mechanisms remained elusive. Protein kinase C (PKC) is a family of serine/threonine kinases and is known to be involved in angiogenesis. The purpose of this study is to elucidate the mechanisms...
12 CitationsSource