Napoleone Ferrara
University of California, San Diego
Vascular endothelial growth factor CCancerEndothelial stem cellInternal medicineEndocrinologyPathologyVascular endothelial growth factor AVascular endothelial growth factor BMolecular biologyReceptorChemistryImmunologyGrowth factorEndotheliumVascular endothelial growth factorNeovascularizationAngiogenesisCancer researchMedicineBiologyCell biology
Publications 362
#1Wei Liang (UCSD: University of California, San Diego)H-Index: 10
#2Qin Li (UCSD: University of California, San Diego)H-Index: 6
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 3 authors...
The tumor-promoting functions of neutrophils have been mainly attributed to induction of tumor angiogenesis or suppression of anticancer immunity. However, a direct impact of neutrophils on tumor cell growth and metastasis remains largely uncharacterized. Here, we coupled a proteomic approach with a functional screen to interrogate the secretome of tumor-associated neutrophils. Surprisingly, the iron-transporting protein transferrin was identified as the major mitogen for tumor cells secreted by...
23 CitationsSource
#1Patrycja Nowak-Sliwinska (University of Geneva)H-Index: 32
#2Kari Alitalo (UH: University of Helsinki)H-Index: 194
Last. Arjan W. Griffioen (VU: VU University Amsterdam)H-Index: 83
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The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the eva...
189 CitationsSource
#1Alena Bartakova (UCSD: University of California, San Diego)H-Index: 12
#2Geoffrey Weiner (UCSD: University of California, San Diego)H-Index: 6
Last. Eric Nudleman (UCSD: University of California, San Diego)H-Index: 14
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The mammalian prokineticins family comprises two conserved proteins, EG-VEGF/PROK1 and Bv8/PROK2, and their two highly related G protein-coupled receptors, PKR1 and PKR2. This signaling system has been linked to several important biological functions, including gastrointestinal tract motility, regulation of circadian rhythms, neurogenesis, angiogenesis and cancer progression, hematopoiesis, and nociception. Mutations in PKR2 or Bv8/PROK2 have been associated with Kallmann syndrome, a development...
20 CitationsSource
#1Hanna M Eilken (WWU: University of Münster)H-Index: 7
#2Rodrigo Diéguez-Hurtado (WWU: University of Münster)H-Index: 10
Last. Ralf H. Adams (WWU: University of Münster)H-Index: 82
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Pericytes adhere to the abluminal surface of endothelial tubules and are required for the formation of stable vascular networks. Defective endothelial cell-pericyte interactions are frequently observed in diseases characterized by compromised vascular integrity such as diabetic retinopathy. Many functional properties of pericytes and their exact role in the regulation of angiogenic blood vessel growth remain elusive. Here we show that pericytes promote endothelial sprouting in the postnatal reti...
80 CitationsSource
#1Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
5 CitationsSource
#1Mara E. Pitulescu (WWU: University of Münster)H-Index: 17
#2Inga Schmidt (WWU: University of Münster)H-Index: 6
Last. Ralf H. AdamsH-Index: 82
view all 16 authors...
Pitulescu et al. and Hasan et al. show that Dll4–Notch signalling in endothelial tip cells regulates angiogenesis through control of artery formation, linking sprouting angiogenesis and artery formation.
117 CitationsSource
#1Vera EreminaH-Index: 19
#2J. Ashley JeffersonH-Index: 21
Last. Susan E. QuagginH-Index: 68
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XUDATIVE AGE-RELATED MACULAR DEGENERAtion results in blindness due to the secondary effects of choroidal neovascularization. Vascular endothelial growth factor (VEGF) has been shown to play a role in the neovascularization associated with exudative age-related macular degeneration. 1-3 Anti-VEGF therapy has shown promise in treating this disease, along with other diseases that demonstrate pathological angiogenesis such as cancer. 4-7 With the success of treating pathological angiogenesis in dise...
#1Hong Xin (UCSD: University of California, San Diego)H-Index: 2
#2Zhong Cuiling (UCSD: University of California, San Diego)H-Index: 2
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
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The VEGF-A isoforms play a crucial role in vascular development, and the VEGF signaling pathway is a clinically validated therapeutic target for several pathological conditions. Alternative mRNA splicing leads to the generation of multiple VEGF-A isoforms, including VEGF165. A recent study reported the presence of another isoform, VEGF-Ax, arising from programmed readthrough translation. Compared to VEGF165, VEGF-Ax has a 22-amino-acid extension in the COOH terminus and has been reported to func...
30 CitationsSource