Noor Hasima Nagoor
University of Malaya
CytotoxicityCancermicroRNACellCytotoxic T cellChemistryApoptosisIn vivoAlpinia conchigeraMTT assayProgrammed cell deathDNA fragmentationCancer researchCell growthMedicineCell cultureBiologyCell biologyCancer cellPharmacology
37Publications
11H-index
378Citations
Publications 37
Newest
#1Devanthiran Letchumanan (UM: University of Malaya)
#2Sophia P. M. Sok (UM: University of Malaya)H-Index: 3
Last. Norhafiza M. Arshad (UM: University of Malaya)H-Index: 4
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Plants are rich in phytoconstituent biomolecules that served as a good source of medicine. More recently, they have been employed in synthesizing metal/metal oxide nanoparticles (NPs) due to their capping and reducing properties. This green synthesis approach is environmentally friendly and allows the production of the desired NPs in different sizes and shapes by manipulating parameters during the synthesis process. The most commonly used metals and oxides are gold (Au), silver (Ag), and copper ...
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#1Sophia P. M. Sok (Nara Institute of Science and Technology)H-Index: 3
#2Daisuke Ori (Nara Institute of Science and Technology)H-Index: 8
Last. Taro Kawai (Nara Institute of Science and Technology)H-Index: 70
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The nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing (NLRP) 3 inflammasome is a multiprotein complex that triggers Caspase-1-mediated IL-1β production and pyroptosis, and its dysregulation is associated with the pathogenesis of inflammatory diseases. The 1'-acetoxychavicol acetate (ACA) is a natural compound in the rhizome of tropical ginger Alpinia species with anti-microbial, -allergic, and -cancer properties. In this study, we found that ACA suppres...
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#1Bavani SubramaniamH-Index: 1
Last. Noor Hasima NagoorH-Index: 11
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1′-acetoxychavicol acetate (ACA) extracted from the rhizomes of Alpinia conchigera Griff (Zingiberaceae) has been shown to deregulate the NF-ĸB signaling pathway and induce apoptosis-mediated cell death in many cancer types. However, ACA is a hydrophobic ester, with poor solubility in an aqueous medium, limited bioavailability, and nonspecific targeting in vivo. To address these problems, ACA was encapsulated in a nanostructured lipid carrier (NLC) anchored with plerixafor octahydrochloride (AMD...
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#1Bavani Subramaniam (UM: University of Malaya)H-Index: 1
#2Zahid H. Siddik (University of Texas MD Anderson Cancer Center)H-Index: 35
Last. Noor Hasima Nagoor (UM: University of Malaya)H-Index: 11
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Lipid-based nanoparticles for drug delivery have been employed in the development of nanomedicine for various applications. One such versatile nanoparticle type is nanostructured lipid carriers (NLCs) that include multiple combinations of lipids and drugs for diverse routes of administrations. Optimization of NLCs to achieve ideal particle size distribution, dispersion in the aqueous environment, long-term stability, drug protection ability, and targeting features is necessary for designing impr...
10 CitationsSource
#1Sharan Malagobadan (UM: University of Malaya)H-Index: 2
#2Chai San Ho (UM: University of Malaya)H-Index: 1
Last. Noor Hasima Nagoor (UM: University of Malaya)H-Index: 11
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Objective: Anoikis is apoptosis that is induced when cells detach from the extracellular matrix and neighboring cells. As anoikis servesas a regulatory barrier, cancer cells often acquire resistance towards anoikis during tumorigenesis to become metastatic. MicroRNAs(miRNAs) are short strand RNA molecules that regulate genes post-transcriptionally by binding to mRNAs and reducing theexpression of its target genes. This study aimed to elucidate the role of a novel miRNA, miR-6744-5p, in regulatin...
1 CitationsSource
#1Hani Sapili (UM: University of Malaya)H-Index: 1
#2Chai San Ho (UM: University of Malaya)H-Index: 1
Last. Noor Hasima Nagoor (UM: University of Malaya)H-Index: 11
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Geranylated 4-phenylcoumarins DMDP-1 and DMDP-2 isolated from Mesua elegans were elucidated for their role in inducing caspase-independent programmed cell death (CI-PCD) in prostate cancer cell lines, PC-3 and DU 145, respectively. Cell homeostasis disruption was demonstrated upon treatment, as shown by the increase in calcium ion through colourimetric assay and endoplasmic reticulum (ER) stress markers GRP 78 and p-eIF2α through western blot. Subsequently, cytoplasmic death protease calpain-2 a...
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#1Su Ki Liew (UM: University of Malaya)H-Index: 3
#2Sharan Malagobadan (UM: University of Malaya)H-Index: 2
Last. Noor Hasima Nagoor (UM: University of Malaya)H-Index: 11
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There are innumerable anticancer compounds derived from either natural or synthetic origins. Many of these compounds have been further developed through structural modifications to not only inhibit cancer cell growth but also to exert an antimetastatic effect. This is achieved by attaching different substituents to generate different structure–activity relationships. This review highlights the effectiveness of different functional groups known to have antimigration and antiproliferation activiti...
3 CitationsSource
#1Menaga Subramaniam (UM: University of Malaya)H-Index: 2
#2Norhafiza M. Arshad (UM: University of Malaya)H-Index: 4
Last. Noor Hasima Nagoor (UM: University of Malaya)H-Index: 11
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Cancer development and progression are extremely complex due to the alteration of various genes and pathways. In most cases, multiple agents are required to control cancer progression. The purpose of this study is to investigate, using a mouse model, the synergistic interactions of anti-cancer agents, 1′-S-1′-acetoxychavicol acetate (ACA), Mycobacterium indicus pranii (MIP), and cisplatin (CDDP) in double and triple combinations to treat chemo-sensitize and immune-sensitize breast cancer. Change...
1 CitationsSource
#1Nurhisyam ZakariaH-Index: 1
Last. Noor Hasima NagoorH-Index: 11
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Background: Pinnatane A from the bark of Walsura pinnata was investigated for its anti-cancer properties by analyzing the cytotoxic activities and cell cycle arrest mechanism induced in two different liver cancer cell lines. Methods: A 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was used to analyze the pinnatane A selectivity in inducing cell death in cancer and normal cells. Various biological assays were carried out to analyze the anti-cancer properties of pinn...
3 CitationsSource
#1Norahayu Othman (UM: University of Malaya)H-Index: 3
#2Noor Hasima Nagoor (UM: University of Malaya)H-Index: 11
: The silencing of Bcl‑xL in the non‑small cell lung cancer (NSCLC) cell line, A549, downregulates miR‑361‑5p expression. This study aimed to determine the biological effects of miR‑361‑5p on NSCLC, and to elucidate the molecular mechanisms through which apoptosis is regulated. MicroRNA (miRNA or miR) functional analyses were performed via transfection of miR‑361‑5p mimics and inhibitors, demonstrating that the inhibition of miR‑361‑5p induced the apoptosis of NSCLC cells. To elucidate the funct...
2 CitationsSource