Allan B. Dietz
Mayo Clinic
CancerInternal medicinePathologyMolecular biologyStromal cellAdipose tissueMesenchymal stem cellImmunologyT cellImmunotherapyDendritic cellCD14MonocyteStem cellCancer researchGeneticsMedicineBiologyImmune systemCell biology
217Publications
46H-index
6,048Citations
Publications 222
Newest
#2Scott M. RiesterH-Index: 21
Last. Andre J. van WijnenH-Index: 1
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#4Allan B. Dietz (Mayo Clinic)H-Index: 46
#5Andre J. van Wijnen (Mayo Clinic)H-Index: 68
Last. Alexander Y. Shin (Mayo Clinic)H-Index: 60
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It was hypothesized that mesenchymal stem cells (MSCs) could provide necessary trophic factors when seeded onto the surfaces of commonly used nerve graft substitutes. We aimed to determine the gene expression of MSCs when influenced by Avance® Nerve Grafts or NeuraGen® Nerve Guides. Human adipose-derived MSCs were cultured and dynamically seeded onto 30 Avance® Nerve Grafts and 30 NeuraGen® Nerve Guides for 12 hours. At six time points after seeding, quantitative polymerase chain reaction analys...
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#1Hayman Lui (Griffith University)H-Index: 3
#2Janet M. Denbeigh (Mayo Clinic)H-Index: 8
Last. Andre J. van Wijnen (Mayo Clinic)H-Index: 68
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Abstract Introduction Culture conditions and differentiation cocktails may facilitate cell maturation and extracellular matrix (ECM) secretion and support the production of engineered fibroblastic tissues with applications in ligament regeneration. The objective of this study is to investigate the potential of two connective tissue-related ligands (i.e., BMP6 and GDF5) to mediate collagenous ECM synthesis and tissue maturation in vitro under normoxic and hypoxic conditions based on the hypothesi...
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#1Elena AtanasovaH-Index: 9
#2Dragana MilosevicH-Index: 16
Last. Allan B. DietzH-Index: 46
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#1Timothy D. Wiltshire (Mayo Clinic)H-Index: 4
#2Michael C. Deeds (Mayo Clinic)H-Index: 6
Last. Dennis A. Gastineau (Mayo Clinic)H-Index: 65
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Abstract null null Background null The rise of investigative and commercially available cell therapy products adds a new dynamic to academic medical centers; that is, the management of patient-specific cell products. The scope of cell therapy has rapidly expanded beyond in-house collection and infusion of cell products such as bone marrow and peripheral blood transplant. The complexities and volumes of cell therapies are likely to continue to become more demanding. As patient-specific “living dr...
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#1Caroline Struijk (Mayo Clinic)H-Index: 1
#2Wouter Van Genechten (Mayo Clinic)H-Index: 2
Last. Daniel B.F. Saris (University Medical Center Utrecht)H-Index: 56
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Meniscus allograft transplantations (MAT) represent established surgical procedures with proven outcomes. Yet, storage as frozen specimens and limited cellular repopulation may impair graft viability. This proof of concept study tests the feasibility of injecting allogeneic mesenchymal stromal/stem cells (MSCs) in meniscus allograft tissue. We investigated the injectable cell quantity, survival rate, migration and proliferation ability of MSCs up to 28 days of incubation. In this controlled labo...
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#1Anupam Kotwal (UNMC: University of Nebraska Medical Center)H-Index: 11
#2Svetlana Bornschlegl (Mayo Clinic)H-Index: 7
Last. Mabel Ryder (Mayo Clinic)H-Index: 19
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#1Timothy D. Wiltshire (Mayo Clinic)H-Index: 4
#2Dragana Milosevic (Mayo Clinic)H-Index: 16
Last. Allan B. Dietz (Mayo Clinic)H-Index: 46
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Abstract Background Aims Viral vectors are commonly used to introduce chimeric antigen receptor (CAR) constructs into cell therapy products for the treatment of human disease. They are efficient at gene delivery and integrate into the host genome for subsequent replication but also carry risks if replication-competent lentivirus (RCL) remains in the final product. An optimal CAR T-cell product should contain sufficient integrated viral material and no RCL. Current product testing methods include...
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#1Stephen C. Textor (Mayo Clinic)H-Index: 78
#2Abdu Abumoawad (MU: University of Missouri)H-Index: 1
Last. Allan B. Dietz (Mayo Clinic)H-Index: 46
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Ischemic nephropathy reflects progressive loss of kidney function due to large vessel atherosclerotic occlusive disease. Recent studies indicate that this process is characterized by microvascular rarefaction, increased tissue hypoxia and activation of inflammatory processes of tissue injury. This review summarizes the rationale and application of functional MR imaging to evaluate tissue oxygenation in human subjects that defines the limits of renal adaptation to reduction in blood flow, develop...
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