Daniëlle Fiechter
Utrecht University
Internal medicineEndocrinologyImmunoglobulin ELipid AAntigenImmunotoxicologyAlkaline phosphataseChemistryImmunologyIn vivoAllergyFood allergyT cellSensitizationInflammationOral administrationPeanut allergyCytokineAcetaminophenLipopolysaccharideMesenteric lymph nodesFOXP3ToxicityT lymphocyteAllergic sensitizationAryl hydrocarbon receptorDegranulationMedicineIL-2 receptorBiologyImmune systemPharmacology
15Publications
8H-index
429Citations
Publications 15
Newest
#1Lydia M. Kwast (UU: Utrecht University)H-Index: 5
#2Tetsuo Aida (Daiichi Sankyo)H-Index: 6
Last. Raymond Pieters (UU: Utrecht University)H-Index: 36
view all 8 authors...
Immune-mediated drug hypersensitivity reactions (IDHR) may result from immuno-sensitization to a drug-induced neo-antigen. They rarely occur in patients and are usually not predicted preclinically using standard toxicity studies. To assess the potential of a drug to induce T-cell sensitization, trinitrophenyl (TNP)-Ficoll was used here as a bystander antigen in animal experiments. TNP-Ficoll will only elicit TNP-specific IgG antibodies in the presence of non-cognate T-cell help. Therefore, the p...
1 CitationsSource
#1Lydia M. Kwast (UU: Utrecht University)H-Index: 5
#2Daniëlle Fiechter (UU: Utrecht University)H-Index: 8
Last. Raymond Pieters (UU: Utrecht University)H-Index: 36
view all 8 authors...
The development of immune-dependent drug hypersensitivity reactions (IDHR) is likely to involve activation of the innate immune system to stimulate neo-antigen specific T-cells. Previously it has been shown that, upon oral exposure to several drugs with immune-adjuvant capacity, mice developed T-cell-dependent responses to TNP-OVA. These results were indicative of the adjuvant potential of these drugs. The present study set out to evaluate the nature of this adjuvant potential by focusing on ear...
2 CitationsSource
#1Shyamali Jayasena (NU: University of Nebraska–Lincoln)H-Index: 4
#2Mieke Smits (UU: Utrecht University)H-Index: 6
Last. Stef J. Koppelman (NU: University of Nebraska–Lincoln)H-Index: 31
view all 9 authors...
Six commercial peanut enzyme-linked immunosorbent assay kits were assessed for their ability to recover peanut from the standard reference material 2387 peanut butter and also for their specificity in detecting four major peanut allergens, Ara h 1, Ara h 2, Ara h 3, and Ara h 6. The percentage recovery of peanut from peanut butter differed across different kits as well as at different sample concentrations. The highest recovery was observed with the Romer and R-Biopharm kits, while four other ki...
45 CitationsSource
#1Veronica J. Schulz (UU: Utrecht University)H-Index: 1
#2Joost J. Smit (UU: Utrecht University)H-Index: 25
Last. Raymond Pieters (UU: Utrecht University)H-Index: 36
view all 13 authors...
Recently, we have shown that AhR activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppresses sensitization to peanut at least in part by inducing a functional shift toward CD4(+)CD25(+)Foxp3(+) T cells. Next to TCDD, numerous other AhR ligands have been described. In this study, we investigated the effect of three structurally different non-dioxin-like AhR ligands, e.g., 6-formylindolo[3,2-b]carbazole (FICZ), β-naphthoflavone (β-NF), and 6-methyl-1,3,8-trichlorodibenzofuran (6-MCDF), on ...
17 CitationsSource
#1Joost J. Smit (UU: Utrecht University)H-Index: 25
#2Karina Willemsen (UU: Utrecht University)H-Index: 3
Last. Raymond Pieters (UU: Utrecht University)H-Index: 36
view all 10 authors...
Food allergy affects approximately 5% of children and is the leading cause of hospitalization for anaphylactic reactions in westernized countries. However, the pathways of anaphylaxis in food allergy are still relatively unknown. We investigated the effector pathways of allergic and anaphylactic responses of different strains of mice in a clinical relevant model of peanut allergy. C3H/HeOuJ, C57BL/6 and BALB/c mice were sensitized by intragastric peanut extract and challenged by intragastric or ...
51 CitationsSource
#1Irene Antolino-Lobo (UU: Utrecht University)H-Index: 4
#2Irene S. Ludwig (UU: Utrecht University)H-Index: 12
Last. Majorie B.M. van Duursen (UU: Utrecht University)H-Index: 17
view all 9 authors...
Source
#1Daniëlle FiechterH-Index: 8
#2Suzanne Kats (Maastricht University Medical Centre)H-Index: 8
Last. Willem SeinenH-Index: 60
view all 7 authors...
Background : There has been increasing evidence suggesting that lipopolysaccharide or endotoxin may be an important activator of the innate immune system after acute myocardial infarction. Bovine intestinal alkaline phosphatase reduces inflammation in several endotoxin mediated diseases by dephosphorylation of the lipid A moiety of lipopolysaccharide. The aim of this study was to investigate the effect of bovine intestinal alkaline phosphatase on reducing inflammation after acute myocardial infa...
2 CitationsSource
#1V.J. Schulz (UU: Utrecht University)H-Index: 4
#2Joost J. Smit (UU: Utrecht University)H-Index: 25
Last. Raymond Pieters (UU: Utrecht University)H-Index: 36
view all 10 authors...
Food allergy is an increasing health problem in Western countries. Previously, it has been shown that the intensity of food allergic reactions can be regulated by regulatory T (Treg) cells. In addition, it has been shown that activation of the aryl hydrocarbon receptor (AhR) regulates T cell responses by induction of Treg cells. Therefore, we hypothesized that activation of the AhR-pathway can suppress development of food allergic responses through the induction of Treg cells. This was investiga...
52 CitationsSource
#1Joost J. Smit (UU: Utrecht University)H-Index: 25
#2M. Bol-Schoenmakers (UU: Utrecht University)H-Index: 14
Last. Raymond Pieters (UU: Utrecht University)H-Index: 36
view all 7 authors...
Cite this as: J. J. Smit, M. Bol-Schoenmakers, I. Hassing, D. Fiechter, L. Boon, R. Bleumink and R. H. H. Pieters, Clinical & Experimental Allergy, 2011 (41) 890–898. Summary Background Food allergy affects approximately 6% of children and is the leading cause of hospitalization for anaphylactic reactions in westernized countries. Crucial in the establishment of allergy is the activation of dendritic cells (DC) leading to T helper 2-mediated responses. Objective We, therefore, investigated wheth...
45 CitationsSource
#1Lydia M. Kwast (UU: Utrecht University)H-Index: 5
#2Daniëlle Fiechter (UU: Utrecht University)H-Index: 8
Last. Raymond Pieters (UU: Utrecht University)H-Index: 36
view all 7 authors...
Immune-mediated drug hypersensitivity reactions are important causes of black box warnings and drug withdrawals. Despite the high demand for preclinical screening tools, no validated in vitro or in vivo models are available. In the current study, we used a previously described oral administration model using trinitrophenyl-ovalbumin (TNP-OVA) as an antigen to report immuno-adjuvating effects of the analgesic drug acetaminophen (APAP) and its nonhepatotoxic regioisomer 3#-hydroxyacetanilide (AMAP...
8 CitationsSource