Lukas M. Löffel
University of Bern
Internal medicineSurgeryRenal functionCardiologyRandomized controlled trialCohort studyClinical endpointHazard ratioObservational studyCystectomyUrinary diversionRestenosisStentNorepinephrine (medication)CreatininePercutaneous coronary interventionAcute kidney injuryZotarolimusAnalgesicBupivacaineGastrointestinal functionPerioperativeAnesthesiaMyocardial infarctionRisk factorMedicineCohortComplication
18Publications
5H-index
176Citations
Publications 20
Newest
#1Marc A. Furrer (University of Melbourne)H-Index: 9
#2Janine Abgottspon (University of Bern)
Last. Patrick Y. Wuethrich (University of Bern)H-Index: 13
view all 8 authors...
OBJECTIVE To assess if uninterrupted anticoagulant agents' administration affects blood loss and blood transfusion during open radical cystectomy (RC) and urinary diversion. PATIENTS AND METHODS We conducted an observational single-centre cohort study of a consecutive series of 1430 RC patients, between 2000 and 2020. Blood loss was depicted according to body weight and duration of surgery (mL/kg/h), and blood transfusion. The group 'with anticoagulant agents' was considered if surgery was perfo...
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#1Lukas M. Löffel (University of Bern)H-Index: 5
#2Robert G. Hahn (KI: Karolinska Institutet)H-Index: 54
Last. Patrick Y. Wuethrich (University of Bern)H-Index: 13
view all 4 authors...
Background The intraoperative effect of 20% albumin on plasma volume during surgery involving major blood loss has not been explored extensively due to methodological difficulties. Crystalloids poorly expand the plasma volume, and using a colloid might then be a way to avoid fluid overload. As doubts have been raised about synthetic colloids, albumin solutions are currently used more extensively. This study presents a methodological development showing how plasma volume expansion can be studied ...
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#1Dominique Engel (University of Bern)H-Index: 2
#2Lukas M. Löffel (University of Bern)H-Index: 5
Last. Robert G. Hahn (KI: Karolinska Institutet)H-Index: 54
view all 4 authors...
Background. Postoperative elevation of plasma creatinine is a frequent complication to major surgery. A rise by 50% fulfils the criterion for Acute Kidney Injury. We studied the relationship between concentrated urine before surgery, which is a sign of dehydration or chronically low intake of water, and the perioperative change in plasma creatinine. Methods. The creatinine concentration was measured in plasma and urine just before and at 6 h, 1 day, and 2 days after major abdominal surgery in a ...
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#1Dominique Engel (University of Bern)H-Index: 2
#2Christian M. Beilstein (University of Bern)H-Index: 4
Last. Patrick Y. Wuethrich (University of Bern)H-Index: 13
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Open radical cystectomy is associated with a substantial rate of perioperative blood transfusion. Early detection of potentially modifiable perioperative factors could reduce the need for perioperative blood transfusion and thus positively impact the outcome. We conducted an observational, single-center cohort study of 1168 patients undergoing cystectomy. Perioperative blood transfusion was defined as the need for packed red blood cells and/or fresh frozen plasma units within the first 24 h afte...
Source
#1Lukas M. Löffel (University of Bern)H-Index: 5
#2Dominique Engel (University of Bern)H-Index: 2
Last. Patrick Y. Wuethrich (University of Bern)H-Index: 13
view all 3 authors...
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#1John-Patrik Burkhard (University of Bern)H-Index: 1
#2Jelena Pfister (University of Bern)
Last. Patrick Y. Wuethrich (University of Bern)H-Index: 13
view all 11 authors...
Objectives The aim of this study was to determine the influence of perioperative fluid management and administration of vasopressors on early surgical revision and flap-related complications in free tissue transfer. Materials and methods Intraoperative amount of fluid and of vasopressors, relevant perioperative parameters, and comorbidities were recorded in 131 patients undergoing head and neck microvascular reconstruction and compared with early surgical complications, defined as interventions ...
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#1Lukas M. Löffel (University of Bern)H-Index: 5
#2Kaspar F. Bachmann (University of Bern)H-Index: 3
Last. Patrick Y. Wuethrich (University of Bern)H-Index: 13
view all 4 authors...
Abstract Study objective To assess the risk for postoperative acute kidney injury (AKI) after major urologic surgery for different intraoperative hypotension thresholds in form of time below a fixed threshold. We hypothesize that the duration of hypotension below a certain hypotension threshold is a risk factor for AKI also in major urologic procedures. Design Retrospective observational cohort series. Setting Single tertiary high caseload center. Patients 416 consecutive patients undergoing ope...
Source
#1Dominique Engel (University of Bern)H-Index: 2
#2Christian M. Beilstein (University of Bern)H-Index: 4
Last. Patrick Y. Wuethrich (University of Bern)H-Index: 13
view all 4 authors...
Source
#1Dominique EngelH-Index: 2
#2Marc A. FurrerH-Index: 9
Last. Lukas M. LöffelH-Index: 5
view all 4 authors...
Purpose The aim of this review is to present an anesthesiological overview on surgical safety for radical cystectomy implementing the cornerstones of today's rapidly evolving field of perioperative medicine.
Source
#1Lukas M. Löffel (University of Bern)H-Index: 5
#2Tobias Gross (University of Bern)H-Index: 14
Last. Marc A. Furrer (University of Bern)H-Index: 9
view all 8 authors...
Abstract Objective To impartially optimize complication reporting in patients after open radical prostatectomy (ORP) and pelvic lymph node dissection (PLND) by adopting the modified Bern Comprehensive Complication Index (CCI). ORP and PLND are associated with relevant postoperative morbidity. The CCI—ranging from 0 (no complications) to 100 (death)—is a tool that aims to integrate all complications occuring within 90 days postoperatively weighted by severity in a single formula. Methods In an ob...
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