Christoph J. Auernhammer
Ludwig Maximilian University of Munich
Internal medicineRadiologyPET-CTEndocrinologyPathologyOncologyMolecular biologyReceptorChemistryImmunologyPositron emission tomographyCytokineNeuroendocrine tumorsNuclear medicineRadionuclide therapyCancer researchViability assaySignal transductionMedicineProtein kinase BCell culturePI3K/AKT/mTOR pathwayBiologyCell biology
157Publications
31H-index
4,046Citations
Publications 146
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#1Adrien Holzgreve (LMU: Ludwig Maximilian University of Munich)H-Index: 3
#2Matthias P. Fabritius (LMU: Ludwig Maximilian University of Munich)H-Index: 7
Last. Marcus Unterrainer (LMU: Ludwig Maximilian University of Munich)H-Index: 16
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Benign so-called “brown tumors” secondary to hyperparathyroidism are a rare diagnostic pitfall due to their impressively malignant-like character in various imaging modalities. We present the case of a 65-year-old male patient with multiple unclear osteolytic lesions on prior imaging suspicious for metastatic malignant disease. Eventually, findings of 18F-FDG PET/CT staging and 99mTc-MIBI scintigraphy resulted in revision of the initially suspected malignant diagnosis. This case illustrates how ...
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Radiolabelled somatostatin analogues targeting somatostatin receptors (SSR) are well established for combined positron emission tomography/computer tomography (PET/CT) imaging of neuroendocrine tumours (NET). [18F]SiTATE has recently been introduced showing high image quality, promising clinical performance and improved logistics compared to the clinical reference standard 68Ga-DOTA-TOC. Here we present the first dosimetry and optimal scan time analysis. Eight NET patients received a [18F]SiTATE...
1 CitationsSource
#1Paul Rogowski (LMU: Ludwig Maximilian University of Munich)H-Index: 5
#2Rieke von Bestenbostel (LMU: Ludwig Maximilian University of Munich)H-Index: 1
Last. Stefanie Corradini (LMU: Ludwig Maximilian University of Munich)H-Index: 19
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Purpose To assess the feasibility and early results of online adaptive MR-guided radiotherapy (oMRgRT) of liver tumors. Methods We retrospectively examined consecutive patients with primary or secondary liver lesions treated at our institution using a 0.35T hybrid MR-Linac (Viewray Inc., Mountain View, CA, USA). Online-adaptive treatment planning was used to account for interfractional anatomical changes, and real-time intrafractional motion management using online 2D cine MRI was performed usin...
7 CitationsSource
#1Xi-Feng JinH-Index: 3
#2Gerald SpöttlH-Index: 13
Last. Christoph J. AuernhammerH-Index: 31
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Objectives: This study assessed the antitumoral activity of the MEK inhibitor trametinib (TMT212) and the ERK1/2 inhibitor SCH772984, alone and in combination with the CDK4/6 inhibitor ribociclib (LEE011) in human neuroendocrine tumor (NET) cell lines in vitro. Methods: Human NET cell lines BON1, QGP-1, and NCI-H727 were treated with trametinib or SCH772984, alone and in combination with ribociclib, to assess cell proliferation, cell cycle distribution, and protein signaling using cell prolifera...
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#1Anja Rinke (University of Marburg)H-Index: 22
#2Christoph J. Auernhammer (LMU: Ludwig Maximilian University of Munich)H-Index: 31
Last. Thomas M. Gress (University of Marburg)H-Index: 82
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Gastroenteropancreatic neuroendocrine neoplasia (GEPNEN) comprises clinically as well as prognostically diverse tumour entities often diagnosed at late stage. Current classification provides a uniform terminology and a Ki67-based grading system, thereby facilitating management. Advances in the study of genomic and epigenetic landscapes have amplified knowledge of tumour biology and enhanced identification of prognostic and potentially predictive treatment subgroups. Translation of this genomic a...
1 CitationsSource
#2Moritz L Schnitzer (LMU: Ludwig Maximilian University of Munich)H-Index: 3
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Neuroendocrine tumors (NETs) are relatively rare neoplasms arising from the hormone-producing neuroendocrine system that can occur in various organs such as pancreas, small bowel, stomach and lung. As the majority of these tumors express somatostatin receptors (SSR) on their cell membrane, utilization of SSR analogs in nuclear medicine is a promising, but relatively costly approach for detection and localization. The aim of this study was to analyze the cost-effectiveness of 68Ga-DOTA-TATE PET/C...
1 CitationsSource
#1Christine Woischke (LMU: Ludwig Maximilian University of Munich)H-Index: 7
#2Peter Jung (LMU: Ludwig Maximilian University of Munich)H-Index: 3
Last. Jens Neumann (LMU: Ludwig Maximilian University of Munich)H-Index: 27
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We present two rare cases of mixed large cell neuroendocrine carcinoma and squamous cell carcinoma of the colon. A literature search revealed only three published cases with similar histology but none of these reports provided profound molecular and mutational analyses. Our two cases exhibited a distinct, colon-like immunophenotype with strong nuclear CDX2 and β-catenin expression in more than 90% of the tumour cells of both components. We analysed the two carcinomas regarding microsatellite sta...
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#1Florian Bösch (LMU: Ludwig Maximilian University of Munich)H-Index: 8
#2Annelore Altendorf-Hofmann (Schiller International University)H-Index: 5
Last. Thomas Knösel (LMU: Ludwig Maximilian University of Munich)H-Index: 34
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Introduction: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are an increasing tumor entity. Since many patients are diagnosed at an advanced stage, treatment is still challenging and dependent on many tumor and patient specific factors. Therefore, the aim of the present study was to elucidate the expression rates and the prognostic value of vascular endothelial growth factor receptor (VEGFR) 1-3 in GEP-NENs. A potential association to immune checkpoint markers was further investigat...
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#1Florian Bösch (LMU: Ludwig Maximilian University of Munich)H-Index: 8
#2Harun Ilhan (LMU: Ludwig Maximilian University of Munich)H-Index: 19
Last. Martin K. AngeleH-Index: 39
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Background: Radioembolization (RE) is well established in the treatment of neuroendocrine liver metastases. However surgery is rarely performed after RE, although liver resection is the gold standard in the treatment of localized neuroendocrine liver metastases. Therefore, aim of the present study was to evaluate the safety and feasibility of liver resection after RE in a homogenous cohort. Methods: From a prospective surgical (n=494) and nuclear medical (n=138) database patients with NELM who u...
3 CitationsSource