Antonio Torsello
University of Milano-Bicocca
NeuropeptideInternal medicineEndocrinologyReceptorChemistryIn vitroIn vivoStimulationSomatostatinAntagonistHypothalamusPilocarpineGhrelinGrowth hormone–releasing hormoneGrowth hormoneGrowth hormone secretionPeptide hormoneHormoneMedicineBiologyPharmacology
130Publications
36H-index
4,149Citations
Publications 132
Newest
#2Elena Bresciani (University of Milano-Bicocca)H-Index: 11
Last. Antonio Torsello (University of Milano-Bicocca)H-Index: 36
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Androgens in women, as well as in men, are intrinsic to maintenance of (i) reproductive competency, (ii) cardiac health, (iii) appropriate bone remodeling and mass retention, (iii) muscle tone and mass, and (iv) brain function, in part, through their mitigation of neurodegenerative disease effects. In recognition of the pluripotency of endogenous androgens, exogenous androgens, and selected congeners, have been prescribed off-label for several decades to treat low libido and sexual dysfunction i...
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1 CitationsSource
#1Ramona MeantiH-Index: 3
#2Laura RizziH-Index: 3
Last. Antonio TorselloH-Index: 36
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Hexarelin, a synthetic hexapeptide, exerts cyto-protective effects at the mitochondrial level in cardiac and skeletal muscles, both in vitro and in vivo, may also have important neuroprotective bioactivities. This study examined the inhibitory effects of hexarelin on hydrogen peroxide (H2O2)-induced apoptosis in Neuro-2A cells. Neuro-2A cells were treated for 24 h with various concentrations of H2O2 or with the combination of H2O2 and hexarelin following which cell viability and nitrite (NO2 −) ...
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#1Lorenza ScottiH-Index: 38
Last. Antonella Zambon (University of Milano-Bicocca)H-Index: 31
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ABSTRACT Objective To evaluate the association of all RAAS inhibitors, ACE inhibithors (ACEIs) and angiotensin II receptor blockers (ARBs) on dementia onset (any dementia, Alzheimer’s disease and vascular dementia) using a meta-analytic approach. Methods A systematic MEDLINE search was carried out to identify all observational studies published up to the 30th September 2020 evaluating the association between RAAS inhibitors and risk of dementia. Studies were included if original investigations c...
1 CitationsSource
Palmitoylethanolamide (PEA) is an endogenous lipid produced on demand by neurons and glial cells that displays neuroprotective properties. It is well known that inflammation and neuronal damage are strictly related processes and that microglia play a pivotal role in their regulation. The aim of the present work was to assess whether PEA could exert its neuroprotective and anti-inflammatory effects through the modulation of microglia reactive phenotypes. In N9 microglial cells, the pre-incubation...
3 CitationsSource
#1Marco TuratiH-Index: 10
#2Nicolò ZanchiH-Index: 3
Last. M Bigoni
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#1Ramona Meanti (University of Milano-Bicocca)H-Index: 3
#2Laura Rizzi (University of Milano-Bicocca)H-Index: 3
Last. Antonio Torsello (University of Milano-Bicocca)H-Index: 36
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Abstract Hexarelin, a synthetic hexapeptide, protects cardiac and skeletal muscles by inhibiting apoptosis, both in vitro and in vivo. Moreover, evidence suggests that hexarelin could have important neuroprotective bioactivity. Oxidative stress and the generation of free radicals has been implicated in the etiologies of several neurodegenerative diseases, including amyotrophic lateral sclerosis, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease and multiple sclerosis. In addition to...
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#1Marco TuratiH-Index: 10
#2Davide Maggioni (University of Milano-Bicocca)H-Index: 11
Last. Marco Bigoni (University of Milano-Bicocca)H-Index: 18
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The specific etiology of meniscal tears, including the mechanism of lesion, location, and orientation, is considered for its contribution to subsequent joint cytokine responsiveness, healing outcomes, and by extension, appropriate lesion-specific surgical remediation. Meniscal repair is desirable to reduce the probability of development of posttraumatic osteoarthritis (PTOA) which is strongly influenced by the coordinate generation of pro- and anti-inflammatory cytokines by the injured cartilage...
2 CitationsSource
#1Morris Losurdo (University of Milano-Bicocca)H-Index: 4
#2Matteo Pedrazzoli (University of Verona)H-Index: 3
Last. Silvia Coco (University of Milano-Bicocca)H-Index: 21
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The critical role of neuroinflammation in favoring and accelerating the pathogenic process in Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a potential therapeutic strategy to slow down the disease progression. In this scenario, mesenchymal stem cells (MSCs) have risen considerable interest thanks to their immunomodulatory properties, which have been largely ascribed to the release of extracellular vesicles (EVs), namely exosomes and microvesicles. Ind...
38 CitationsSource
#2Laura Rizzi (University of Milano-Bicocca)H-Index: 3
Last. Antonio Torsello (University of Milano-Bicocca)H-Index: 36
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Neurodegenerative diseases, including Alzheimer disease (AD), Parkinson disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Huntington disease, are characterized by the loss of neurons as well as neuronal function in multiple regions of the central and peripheral nervous systems. Several studies in animal models have shown that androgens have neuroprotective effects in the brain and stimulate axonal regeneration. The presence of neuronal androgen receptors in the peri...
2 CitationsSource