Luke P. Brewster
Emory University
RadiologyBiomedical engineeringSurgeryOdds ratioCardiologyRetrospective cohort studyIntensive care medicineMesenchymal stem cellAmputationVascular surgeryStentRevascularizationStenosisCarotid endarterectomyCritical limb ischemiaPopulationPerioperativePeripheralMedicineFibroblast growth factor
Publications 136
Last. Luke P. BrewsterH-Index: 19
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#1Ahmed Ismaeel (FSU: Florida State University)H-Index: 6
#2Evlampia Papoutsi (FSU: Florida State University)H-Index: 7
Last. Panagiotis Koutakis (FSU: Florida State University)H-Index: 15
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Peripheral artery disease (PAD) pathophysiology extends beyond hemodynamics to include other operating mechanisms, including endothelial dysfunction. Oxidative stress may be linked to endothelial dysfunction by reducing nitric oxide (NO) bioavailability. We aimed to investigate whether the NO system and its regulators are altered in the setting of PAD and to assess the relationship between NO bioavailability and oxidative stress. Sera from 35 patients with intermittent claudication (IC), 26 pati...
2 CitationsSource
#1Anurag Mehta (Emory University)H-Index: 10
#2Kreton Mavromatis (Emory University)H-Index: 22
Last. Arshed A. Quyyumi (Emory University)H-Index: 92
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Abstract Background Lower extremity peripheral arterial disease (PAD) is a public health problem and many patients with PAD experience claudication despite adequate medical and/or surgical management. Mobilization of endogenous progenitor cells using Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is a novel therapeutic option that has shown promising results in experimental models and phase I/IIA trials. The GPAD-3 trial will study the effect of two successive administrations of GM-CS...
#1Sanjay MisraH-Index: 41
#1Sanjay MisraH-Index: 22
Last. Kathleen RichH-Index: 5
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There are >12 million patients with peripheral artery disease in the United States. The most severe form of peripheral artery disease is critical limb ischemia (CLI). The diagnosis and management o...
22 CitationsSource
#1Adam Prasanphanich (Emory University)H-Index: 7
#2Christopher T. Johnson (Emory University)H-Index: 11
Last. J. David Prologo (Emory University)H-Index: 11
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Abstract Purpose To evaluate the feasibility of catheter-directed intra-arterial stem cell delivery of human mesenchymal stem cells (MSCs) to the small bowel in a porcine model. Materials and Methods The cranial mesenteric artery of 6 Yucatan minipigs was selectively catheterized under fluoroscopic guidance following cut-down and carotid artery access. A proximal jejunal branch artery was selectively catheterized for directed delivery of embolic microspheres (100–300 μm) or MSCs (0.1–10 million ...
1 CitationsSource
#1Sidd Dalal (Mercer University)H-Index: 2
#2Luke P. Brewster (Georgia Institute of Technology)H-Index: 19
Ethics in laboratory research has become a formalized training course, and the reasons for this are multiple. Given the multiple unique pressures experienced by surgeons, the concepts taught in these ethic courses are particularly relevant. Here the concepts will be discussed in a case-based format including issues highly relevant to surgeons.
#1Emily Lagergren (Emory University)H-Index: 1
#2Deena B. Chihade (Emory University)H-Index: 4
Last. Yazan Duwayri (Emory University)H-Index: 11
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Background Endovascular aneurysm repair (EVAR) accounts for the majority of all abdominal aortic aneurysm (AAA) repairs in the United States. EVAR utilization in the aging population is increasing due to the minimally invasive nature of the procedure, the low associated perioperative morbidity, and early survival benefit over open repair. The objective of this study is to compare the outcomes of octogenarians after elective EVAR to their younger counterparts, a question that can be answered by a...
10 CitationsSource
#1Tatiana Chadid (Emory University)H-Index: 4
#2Andrew D. Morris (Emory University)H-Index: 4
Last. Luke P. Brewster (Georgia Institute of Technology)H-Index: 19
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Abstract Objective Regenerative medicine seeks to stall or to reverse the pathologic consequences of chronic diseases. Many people with diabetes have peripheral arterial disease (PAD), which increases their already high risk of major amputation. Cellular therapies are a promising regenerative medicine approach to PAD that can be used to focally inject regenerative cells to endangered tissue beds. Mesenchymal stem cells (MSCs) are known to promote tissue regeneration through stromal support and p...
5 CitationsSource
#1Elise R. Breed (Emory University)H-Index: 11
#2Carolyn A. Hilliard (WashU: Washington University in St. Louis)H-Index: 4
Last. Craig M. Coopersmith (Emory University)H-Index: 50
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In vitro studies have implicated the small heat shock protein HSPB1 in a range of physiological functions. However, its in vivo relevance is unclear as the phenotype of unstressed HSPB1−/− mice is unremarkable. To determine the impact of HSPB1 in injury, HSPB1−/− and wild type (WT) mice were subjected to cecal ligation and puncture, a model of polymicrobial sepsis. Ten-day mortality was significantly higher in HSPB1−/− mice following the onset of sepsis (65% vs. 35%). Ex vivo mechanical testing ...
5 CitationsSource