Ken Walder
Deakin University
GeneInternal medicineEndocrinologyGene expressionNeuroscienceChemistryInflammationType 2 diabetesInsulin resistancePsammomysInsulinSkeletal muscleLeptinObesityGeneticsBiochemistryDiabetes mellitusBioinformaticsMedicineBiologyCell biology
Publications 248
#1Chiara C Bortolasci (Deakin University)H-Index: 12
#2Alyna Turner (University of Newcastle)H-Index: 19
Last. Felice N. Jacka (Deakin University)H-Index: 68
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N-acetylcysteine (NAC) acts on glutamatergic and redox systems, two systems implicated in the pathophysiology of bipolar disorder (BD). This has led to the investigation of NAC as a potential candidate for the treatment of BD. The aim of this study was to investigate metabolomic markers to identify predictors of NAC response in a cohort of BD participants. This study is a secondary analysis of a 16-week, multi-site, randomized, double-blinded, parallel-group, placebo-controlled trial in BD parti...
#1Bruna PanizzuttiH-Index: 13
#2Chiara C BortolasciH-Index: 12
Last. Jee Hyun KimH-Index: 27
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Weight gain and consequent metabolic alterations are common side-effects of many antipsychotic drugs. Interestingly, several studies have suggested that improvement in symptoms and adverse metabolic effects are correlated. We used next generation sequencing data from NT-2 (human neuronal) cells treated with aripiprazole, amisulpride, risperidone, quetiapine, clozapine, or vehicle control, and compared with the Pillinger P-score (ranked from 0 to 1, indicating greater increase in weight gain and ...
Abstract null null Chronic systemic inflammation is associated with an increased risk of cardiovascular disease in an environment of low low-density lipoprotein (LDL) and low total cholesterol and with the pathophysiology of neuroprogressive disorders. The causes and consequences of this lipid paradox are explored. Circulating activated neutrophils can release inflammatory molecules such as myeloperoxidase and the pro-inflammatory cytokines interleukin-1 beta, interleukin-6 and tumour necrosis f...
1 CitationsSource
#1Gerwyn Morris (Deakin University)H-Index: 28
#2Ken Walder (Deakin University)H-Index: 36
Last. Andre F. Carvalho (Deakin University)H-Index: 4
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The endocannabinoid system (ECS) comprises two cognate endocannabinoid receptors referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro-psychiatric disorders including but not limited to schizophrenia, major depressive disorder and potentially bipolar disorder. The aim of this paper is to review mechanisms whereby both receptors may interact with neuro-immune and neuro-oxidative pathways, which play a pathophysiological role in these disorders. CB1R is located in ...
1 CitationsSource
#1Rajas P. Kale (Deakin University)H-Index: 5
#2Thanh T. Nguyen (Mayo Clinic)H-Index: 6
Last. Susannah J. TyeH-Index: 23
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The antidepressant actions of deep brain stimulation (DBS) are associated with progressive neuroadaptations within the mood network, modulated in part, by neurotrophic mechanisms. We investigated the antidepressant-like effects of chronic nucleus accumbens (NAc) DBS and its association with change in glycogen synthase kinase 3 (GSK3) and mammalian target of rapamycin (mTOR) expression in the infralimbic cortex (IL), and the dorsal (dHIP) and ventral (vHIP) subregions of the hippocampus of antide...
Recent reports suggest a link between positive regulation of the Hippo pathway with bipolar disorder (BD), and the Hippo pathway is known to interact with multiple other signaling pathways previously associated with BD and other psychiatric disorders. In this study, neuronal-like NT2 cells were treated with amisulpride (10 µM), aripiprazole (0.1 µM), clozapine (10 µM), lamotrigine (50 µM), lithium (2.5 mM), quetiapine (50 µM), risperidone (0.1 µM), valproate (0.5 mM), or vehicle control for 24 h...
1 CitationsSource
#1Daniel Fraher (Deakin University)H-Index: 7
#2Robert J. Mann (Deakin University)H-Index: 1
Last. Yann Gibert (UMMC: University of Mississippi Medical Center)H-Index: 19
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Abstract Osteoporosis is an increasing burden on public health as the world-wide population ages and effective therapeutics are severely needed. Two pathways with high potential for osteoporosis treatment are the retinoic acid (RA) and endocannabinoid system (ECS) signaling pathways. We sought to elucidate the roles that these pathways play in bone development and maturation. Here, we use chemical treatments to modulate the RA and ECS pathways at distinct early, intermediate, and late times bone...
1 CitationsSource
#1Gerwyn Morris (Deakin University)H-Index: 28
#2Elizabeth Gamage (Deakin University)
Last. Wolfgang Marx (Deakin University)H-Index: 20
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The pathophysiology of psychiatric and neurodegenerative disorders is complex and multifactorial. Polyphenols possess a range of potentially beneficial mechanisms of action that relate to the implicated pathways in psychiatric and neurodegenerative disorders. There is now emerging, yet still limited, clinical data demonstrating potential efficacy in a range of neuropsychiatric disorders. However, the large interindividual differences in metabolism related to factors including the gut microbiome ...
#1Gerwyn Morris (Deakin University)H-Index: 28
#2Chiara C Bortolasci (Deakin University)H-Index: 12
Last. Michael Maes (Medical University Plovdiv)H-Index: 9
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Abstract An analysis of published data appertaining to the cytokine storms of COVID-19, H1N1 influenza, cytokine release syndrome (CRS), and macrophage activation syndrome (MAS) reveals many common immunological and biochemical abnormalities. These include evidence of a hyperactive coagulation system with elevated D-dimer and ferritin levels, disseminated intravascular coagulopathy (DIC) and microthrombi coupled with an activated and highly permeable vascular endothelium. Common immune abnormali...
2 CitationsSource
#1Yann Quidé (UNSW: University of New South Wales)H-Index: 14
#2Chiara C Bortolasci (Deakin University)H-Index: 12
Last. Melissa J. Green (UNSW: University of New South Wales)H-Index: 52
view all 10 authors...
BACKGROUND Elevated levels of systemic inflammation are consistently reported in both schizophrenia (SZ) and bipolar-I disorder (BD), and are associated with childhood trauma exposure. We tested whether childhood trauma exposure moderates associations between systemic inflammation and brain morphology in people with these diagnoses. METHODS Participants were 55 SZ cases, 52 BD cases and 59 healthy controls (HC) who underwent magnetic resonance imaging. Systemic inflammation was measured using a ...
6 CitationsSource