Sonia L. Bonifacio
Stanford University
PathologyMagnetic resonance imagingNeurointensive careRandomized controlled trialIntensive care medicinePediatricsProspective cohort studyCohort studyStatus epilepticusHypothermiaNeonatal encephalopathyEpilepsyGestational ageEncephalopathyMEDLINEPopulationHypoxic Ischemic EncephalopathyIntensive careAnesthesiaElectroencephalographyMedicine
68Publications
24H-index
2,006Citations
Publications 69
Newest
Neonatal encephalopathy due to perinatal hypoxia-ischemia (hypoxic-ischemic encephalopathy [HIE]) occurs at a rate of 1 to 3 per 1000 live births. Therapeutic hypothermia is the standard of care and the only currently available therapy to reduce the risk of death or disability in newborns with moderate to severe HIE. Hypothermia therapy needs to be initiated within 6 hours after birth in order to provide the best chance for neuroprotection. All pediatricians and delivery room attendants should b...
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#1Lina F. Chalak (UTSW: University of Texas Southwestern Medical Center)H-Index: 24
#2Lena Hellström-Westas (Uppsala University Hospital)H-Index: 57
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Several bedside and laboratory neuromonitoring tools are currently used in neonatal encephalopathy (NE) to assess 1) brain function [amplitude-integrated electroencephalogram (aEEG) and EEG], 2) cerebral oxygenation delivery and consumption [near-infrared spectroscopy (NIRS)] and 3) blood and cerebrospinal fluid biomarkers. The aim of the review is to provide the role of neuromonitoring in understanding the development of brain injury in these newborns and better predict their long-term outcome....
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#1Ashley M. Bach (UPenn: University of Pennsylvania)
#1Ashley M. Bach (UCSF: University of California, San Francisco)H-Index: 1
Last. Hannah C. Glass (UCSF: University of California, San Francisco)H-Index: 37
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Author(s): Bach, Ashley M; Fang, Annie Y; Bonifacio, Sonia; Rogers, Elizabeth E; Scheffler, Aaron; Partridge, J Colin; Xu, Duan; Barkovich, A James; Ferriero, Donna M; Glass, Hannah C; Gano, Dawn | Abstract: ObjectiveTo evaluate the association of therapeutic hypothermia with magnetic resonance imaging (MRI) findings and 30-month neurodevelopment in term neonatal encephalopathy.Study designCross-sectional analysis of 30-month neurodevelopment (IQR 19.0-31.4) in a prospective cohort of mild-to-se...
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#1Pia Wintermark (MUHC: McGill University Health Centre)H-Index: 2
#2Mohamed El Dib (Harvard University)
Last. Sonia L. Bonifacio (Stanford University)H-Index: 24
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#1Hemmen Sabir (Boston Children's Hospital)H-Index: 18
#2Sonia L. Bonifacio (Stanford University)H-Index: 24
Last. Lina F. Chalak (UTSW: University of Texas Southwestern Medical Center)H-Index: 24
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Therapeutic hypothermia (TH) is now well established to improve intact survival after neonatal encephalopathy (NE). However, many questions could not be addressed by the randomized controlled trials. Should late preterm newborns with NE be cooled? Is cooling beneficial for mild NE? Is the current therapeutic time window optimal, or could it be shortened or prolonged? Will either milder or deeper hypothermia be effective? Does infection/inflammation exposure in the perinatal period in combination...
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#1Pia Wintermark (Montreal Children's Hospital)H-Index: 19
#2Mohamed El Dib (Harvard University)
Last. Sonia L. Bonifacio (Stanford University)H-Index: 24
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#1Courtney J. Wusthoff (Stanford University)H-Index: 28
#2Vandana Sundaram (Stanford University)H-Index: 25
Last. Renée A. Shellhaas (UM: University of Michigan)H-Index: 32
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OBJECTIVE To determine whether screening continuous EEG monitoring (cEEG) is associated with greater odds of treatment success for neonatal seizures. METHODS We included term neonates with acute symptomatic seizures enrolled in the Neonatal Seizure Registry (NSR), a prospective, multicenter cohort of neonates with seizures. We compared two cEEG approaches: (1) Screening cEEG, initiated for indications of encephalopathy or paralysis without suspected clinical seizures, and (2) Confirmatory cEEG, ...
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#1Prashant Agarwal (WSU: Wayne State University)H-Index: 3
#2Seetha Shankaran (WSU: Wayne State University)H-Index: 88
Last. Krisa P. Van Meurs (Stanford University)H-Index: 49
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OBJECTIVE To determine the association of persistent pulmonary hypertension of the newborn (PPHN) with death or disability among infants with moderate or severe hypoxic ischemic encephalopathy (HIE) treated with therapeutic hypothermia. METHODS We compared infants with and without PPHN enrolled in the hypothermia arm from three randomized controlled trials (RCTs): Induced Hypothermia trial, "usual care" arm of Optimizing Cooling trial, and Late Hypothermia trial. Primary outcome was death or dis...
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#1Monica E. Lemmon (Duke University)H-Index: 14
#2Sonia L. Bonifacio (Stanford University)H-Index: 24
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Abstract Background Neonatal seizures are associated with death and neurologic morbidity; however, little is known about how neonates with seizures die. Methods This was a prospective, observational cohort study of neonates with seizures treated at seven sites of the Neonatal Seizure Registry. We characterized mode of death, evaluated the association between infant characteristics and mode of death, and evaluated predictors of death or transfer to hospice. Results We enrolled 611 consecutive neo...
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#1Linda S. Franck (UCSF: University of California, San Francisco)H-Index: 67
#2Renée A. Shellhaas (UM: University of Michigan)H-Index: 32
Last. Sonia L. BonifacioH-Index: 24
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OBJECTIVE: To characterize and determine risk factors for key dimensions of well-being at hospital discharge in families of neonates with acute symptomatic seizures. STUDY DESIGN: This prospective, observational cohort study enrolled 144 parent-infant dyads among neonates with acute symptomatic seizures from 9 pediatric hospitals in the Neonatal Seizure Registry. One parent per family completed a discharge survey, which included measures of anxiety and depression, health-related quality of life,...
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