Filippo Zanetti
University of Geneva
Composite numberEnamel paintChemistryApoptosisBuccal administrationDentistryIn vitroImmunologyOxidative stressToothpasteLungAerosolNicotineContext (language use)Tooth discolorationSystems toxicologyCigarette smokeTobacco productProgrammed cell deathToxicologyPhysiologySmokeMedicineBiologyCell biologyPharmacology
30Publications
11H-index
291Citations
Publications 32
Newest
#1Weidong Weng (University of Tübingen)H-Index: 4
#2Filippo ZanettiH-Index: 11
Last. Romina H. Aspera-Werz (University of Tübingen)H-Index: 10
view all 10 authors...
The extracellular matrix regulates cell survival, proliferation, and differentiation. In vitro two-dimensional cell experiments are typically performed on a plastic plate or a substrate of a single extracellular matrix constituent such as collagen or calcium phosphate. As these approaches do not include extracellular matrix proteins or growth factors, they fail to mimic a complex cell microenvironment. The cell-derived matrix is an alternative platform for better representing the in vivo microen...
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#1Xiaoyi Zhao (PKU: Peking University)H-Index: 7
#2Filippo ZanettiH-Index: 11
Last. Yan-Fang Ren (UR: University of Rochester)H-Index: 23
view all 8 authors...
Purpose To compare the effects of whitening toothpaste and bleaching with 6% hydrogen peroxide (H2O2) on discoloration of dental resin composite caused by cigarette smoke (CS) and electronic vapor product (EVP) aerosol. Methods 40 resin composite discs were divided into three groups: 15 each for CS and EVP aerosol exposure and 10 for air exposure (control). Exposures were performed for 15 days, with daily brushing with regular toothpaste. Two whitening sessions, including 21 days of brushing wit...
#1Carine PoussinH-Index: 15
#2Anita R. IskandarH-Index: 20
Last. Walter K. SchlageH-Index: 24
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Abstract Electronic nicotine delivery products (ENDPs) emit lower levels of toxicants than cigarettes, and, consequently, ENPD aerosols have the potential to be less toxic than cigarette smoke (CS). Toxicological assessment of ENDPs relies heavily on in vitro studies to verify this assertion. First, a battery of standardized and validated regulatory toxicology assays is used to verify that ENDP aerosols are less cytotoxic and genotoxic than CS. Second, a systems toxicology approach is employed t...
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#1Alain SewerH-Index: 23
#2Filippo ZanettiH-Index: 11
Last. Julia HoengH-Index: 31
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Abstract The expression of some microRNAs (miRNA) is modulated in response to cigarette smoke (CS), which is a leading cause of major preventable diseases. However, whether miRNA expression is also modulated by the aerosol/extract from potentially reduced-risk products is not well studied. The present work is a meta-analysis of 12 in vitro studies in human organotypic epithelial cultures of the aerodigestive tract (buccal, gingival, bronchial, nasal, and small airway epithelia). These studies co...
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#1Adrian HaiducH-Index: 1
#2Filippo ZanettiH-Index: 11
Last. Philippe A. GuyH-Index: 41
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Abstract Tobacco smoking contributes to tooth discoloration. Pigmented compounds in the smoke generated by combustion of tobacco can cause discoloration of dental hard tissues. However, aerosols from heated tobacco products cause less discoloration than cigarette smoke (CS) in vitro. The objective of the present study was to optimize a method for extracting the colored chemical compounds deposited on tooth enamel following exposure to total particulate matter (TPM) from CS or a heated tobacco pr...
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#1Sanja Blaskovic (University of Geneva)H-Index: 5
#2Yves Donati (University of Geneva)H-Index: 22
Last. Constance Barazzone-Argiroffo (University of Geneva)H-Index: 17
view all 8 authors...
Harmful consequences of cigarette smoke (CS) exposure during lung development can already manifest in infancy. In particular, early life exposure to nicotine, the main component of CS, was shown to...
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#1Anita R. IskandarH-Index: 20
#2Filippo ZanettiH-Index: 11
Last. Julia HoengH-Index: 31
view all 21 authors...
We previously proposed a systems toxicology framework for in vitro assessment of e-liquids. The framework starts with the first layer aimed at screening the potential toxicity of e-liquids, followed by the second layer aimed at investigating the toxicity-related mechanism of e-liquids, and finally, the third layer aimed at evaluating the toxicity-related mechanism of the corresponding aerosols. In this work, we applied this framework to assess the impact of the e-liquid MESH Classic Tobacco and ...
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#1Xiaoyi Zhao (UR: University of Rochester)H-Index: 7
#2Filippo ZanettiH-Index: 11
Last. Yan-Fang Ren (UR: University of Rochester)H-Index: 23
view all 9 authors...
Abstract Objectives To compare the relative effects of cigarette smoke (CS), electronic cigarette (EC), red wine, coffee, and soy sauce on the color of enamel, dentin, and composite resin restorations, as well as the effects of whitening treatments. Methods Seventy premolars with composite restorations were exposed to CS, EC aerosol (a novel EC device with MESH™ technology [P4M3 version 1.0, Philip Morris International]), red wine, coffee, and soy sauce for 56 minutes/day for 15 days. Two whiten...
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#1Anita R. IskandarH-Index: 20
#2Filippo ZanettiH-Index: 11
Last. Julia HoengH-Index: 31
view all 19 authors...
In the context of tobacco harm-reduction strategy, the potential reduced impact of electronic cigarette (EC) exposure should be evaluated relative to the impact of cigarette smoke exposure. We conducted a series of in vitro studies to compare the biological impact of an acute exposure to aerosols of “test mix” (flavors, nicotine, and humectants), “base” (nicotine and humectants), and “carrier” (humectants) formulations using MarkTen® EC devices with the impact of exposure to smoke of 3R4F refere...
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