Brett L. Ecker
Wistar Institute
Internal medicineRadiologySurgeryOncologyRetrospective cohort studyPropensity score matchingTumor microenvironmentSurvival rateFistulaMelanomaAdjuvant therapyPancreatectomyPancreaticoduodenectomyMetastasisGastrectomyPancreatic fistulaPerioperativeCancer researchProportional hazards modelGeneral surgeryMedicineCohortAnastomosisBiologyGastroenterology
78Publications
19H-index
1,210Citations
Publications 74
Newest
#1Brett L. EckerH-Index: 19
#2Paul ShinH-Index: 1
Last. Michael I. D’AngelicaH-Index: 100
view all 16 authors...
Objective null To determine whether genomic risk groups identified by somatic mutation testing of colorectal liver metastasis (CRLM) can be used for "molecularly-guided" selection for adjuvant systemic chemotherapy and hepatic artery infusion of FUDR (SYS+HAI-FUDR). null Background null Several genomic biomarkers have been associated with clinical phenotype and survival for patients with resectable CRLM. It is unknown whether prognostication afforded by genomic stratification translates into enh...
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#1Fabio Casciani (UPenn: University of Pennsylvania)H-Index: 3
#2Maxwell T. Trudeau (UPenn: University of Pennsylvania)H-Index: 4
Last. Ronald R. SalemH-Index: 30
view all 55 authors...
Abstract Background The association between intraoperative estimated blood loss and outcomes after pancreatoduodenectomy has, thus far, been rarely explored. Methods In total, 7,706 pancreatoduodenectomies performed at 18 international institutions composing the Pancreas Fistula Study Group were examined (2003–2020). High estimated blood loss (>700 mL) was defined as twice the median. Propensity score matching (1:1 exact-match) was employed to adjust for variables associated with high estimated ...
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#1Fabio Casciani (UPenn: University of Pennsylvania)H-Index: 3
#2Maxwell T. Trudeau (UPenn: University of Pennsylvania)H-Index: 4
Last. John W. KunstmanH-Index: 18
view all 55 authors...
Abstract Background Pancreatoduodenectomies at high risk for clinically relevant pancreatic fistula are uncommon, yet intimidating, situations. In such scenarios, the impact of individual surgeon experience on outcomes is poorly understood. Methods The fistula risk score was applied to identify high-risk patients (fistula risk score 7–10) from 7,706 pancreatoduodenectomies performed at 18 international institutions (2003–2020). For each case, surgeon pancreatoduodenectomy career volume and years...
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#1Stephen M. Douglass (Johns Hopkins University)H-Index: 6
#2Mitchell Fane (Johns Hopkins University)H-Index: 11
Last. Ashani T. Weeraratna (Johns Hopkins University)H-Index: 54
view all 15 authors...
Metastatic dissemination remains a significant barrier to successful therapy for melanoma. Wnt5A is a potent driver of invasion in melanoma and is believed to be secreted from the tumor microenvironment. Our data suggest that myeloid-derived suppressor cells (MDSC) in the tumor microenvironment (TME) are a major source of Wnt5A and are reliant upon Wnt5A for multiple actions. Knockdown of Wnt5A specifically in the myeloid cells demonstrated a clear decrease in Wnt5A expression within the TME in ...
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Sarcomas are rare mesenchymal tumors with a propensity for hematogenous metastasis. Gastrointestinal stromal tumor (GIST) is the most common histologic subtype and the most common source of hepatic metastases. In the case of metastatic GIST, neoadjuvant imatinib can be used as a selection tool for the judicious application of surgery, where treatment-responsive patients who undergo resection to prevent the development of treatment-resistant clones have associated 10-year actuarial survival of 40...
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#1Maxwell T. Trudeau (UPenn: University of Pennsylvania)H-Index: 4
#2Fabio Casciani (UPenn: University of Pennsylvania)H-Index: 3
Last. Charles M. Vollmer (UPenn: University of Pennsylvania)H-Index: 67
view all 11 authors...
Abstract Background Weight change offers the simplest indication of a patient’s recovery after an operation. There have been no studies that have thoroughly investigated postoperative weight dynamics after pancreatectomy. The aim of this study was to define postoperative weight change after a pancreatectomy and determine factors associated with optimal and poor weight trajectories. Methods From 2004 to 2019, 1,090 proximal (65%) and distal (35%) pancreatectomies were performed in patients with a...
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#1Mitchell Fane (Johns Hopkins University)H-Index: 11
#2Brett L. Ecker (UPenn: University of Pennsylvania)H-Index: 19
Last. Ashani T. Weeraratna (Johns Hopkins University)H-Index: 54
view all 19 authors...
Purpose: Angiogenesis is thought to be critical for tumor metastasis. However, inhibiting angiogenesis using antibodies such as bevacizumab (Avastin), has had little impact on melanoma patient survival. We have demonstrated that both angiogenesis and metastasis are increased in older individuals, and therefore sought to investigate whether there was an age-related difference in response to bevacizumab, and if so, what the underlying mechanism could be. Experimental Design: We analyzed data from ...
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#2Mitchell FaneH-Index: 11
Last. Brett L. EckerH-Index: 19
view all 15 authors...
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#1Gretchen M. AliceaH-Index: 10
#2Vito W. RebeccaH-Index: 20
Last. Ashani T. WeeraratnaH-Index: 54
view all 11 authors...
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