Roger Lijnen
Katholieke Universiteit Leuven
Matrix metalloproteinaseEndocrinologyPathologyMolecular biologyCardiologyAdipose tissueChemistryFibrinolysisUrokinaseStaphylokinasePlasminogen activatorPlasminogen activator inhibitor-1PlasminCancer researchFibrinBiochemistryMedicineBiologyCell biologyPharmacology
Publications 223
#1Ellen Vercalsteren (Katholieke Universiteit Leuven)H-Index: 2
#2Christine Vranckx (Katholieke Universiteit Leuven)H-Index: 4
Last. Ilse Scroyen (Katholieke Universiteit Leuven)H-Index: 15
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Obesity, caused by an excess adipose tissue, is one of the biggest health-threats of the 21st century. Adipose tissue expansion occurs through two processes: (i) hypertrophy, and (ii) hyperplasia, the formation of new adipocytes, also termed adipogenesis. Recently, serum amyloid A3 (Saa3) has been implicated in adipogenesis. Therefore, the aim of this study was to investigate the effect of Saa3 on adipogenesis using both an in vitro and in vivo murine model. Saa3 gene silenced pre-adipocytes ha ...
#1Claudia Tersteeg (Katholieke Universiteit Leuven)H-Index: 13
#2Bérangère S. Joly (Paris Diderot University)H-Index: 10
Last. Karen Vanhoorelbeke (Katholieke Universiteit Leuven)H-Index: 45
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Background Thrombotic thrombocytopenic purpura (TTP) is an acute life-threatening pathology, caused by occlusive von Willebrand factor (VWF)-rich microthrombi that accumulate in absence of ADAMTS13. We previously demonstrated that plasmin can cleave VWF and that plasmin is generated in patients during acute TTP. However, the exact role for plasmin in TTP remains unclear. Objectives Investigate if endogenous plasmin-mediated proteolysis of VWF can influence acute TTP episodes. Results Also in mic...
9 CitationsSource
#1Claudia TersteegH-Index: 13
#2Bérangère S. JolyH-Index: 10
Last. Karen VanhoorelbekeH-Index: 45
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#1Marijke Peetermans (Katholieke Universiteit Leuven)H-Index: 16
#2Thomas Vanassche (Katholieke Universiteit Leuven)H-Index: 24
Last. Peter Verhamme (Katholieke Universiteit Leuven)H-Index: 56
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AbstractBoth coagulation and fibrinolysis are tightly connected with the innate immune system. Infection and inflammation cause profound alterations in the otherwise well-controlled balance between coagulation and fibrinolysis. Many pathogenic bacteria directly exploit the host’s hemostatic system to increase their virulence. Here, we review the capacity of bacteria to activate plasminogen. The resulting proteolytic activity allows them to breach tissue barriers and evade innate immune defense, ...
30 CitationsSource
#1Samuel Hernandez-Anzaldo (U of A: University of Alberta)H-Index: 7
#2Vesna Brglez (CNRS: Centre national de la recherche scientifique)H-Index: 9
Last. Carlos Fernandez-Patron (U of A: University of Alberta)H-Index: 25
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Background The development of atherosclerosis is strongly linked to disorders of cholesterol metabolism. Matrix metalloproteinases (MMPs) are dysregulated in patients and animal models with atherosclerosis. Whether systemic MMP activity influences cholesterol metabolism is unknown. Methods and Results We examined MMP‐9–deficient ( Mmp9 −/− ) mice and found them to have abnormal lipid gene transcriptional responses to dietary cholesterol supplementation. As opposed to Mmp9 +/+ (wild‐type) mice, M...
11 CitationsSource
#1Lotte GeysH-Index: 4
#2Dries BautersH-Index: 11
Last. Ilse ScroyenH-Index: 15
view all 8 authors...
ADAMTS13 cleaves ultralarge multimeric von Willebrand Factor (VWF), thereby preventing formation of platelet-rich microthrombi. ADAMTS13 is mainly produced by hepatic stellate cells, and numerous studies have suggested a functional role of ADAMTS13 in the pathogenesis of liver diseases. The aim of our study was to investigate a potential role of ADAMTS13 in formation of hepatic microthrombi and development of non-alcoholic steatohepatitis (NASH), and furthermore to evaluate whether plasmin can c...
10 CitationsSource
#1Lotte GeysH-Index: 4
#2Elien RooseH-Index: 8
Last. Karen VanhoorelbekeH-Index: 2
view all 8 authors...
#1Dries BautersH-Index: 11
#2Ilse ScroyenH-Index: 15
Last. Roger LijnenH-Index: 15
view all 4 authors...
#1Lotte GeysH-Index: 4
#2Roger LijnenH-Index: 15
Last. Ilse ScroyenH-Index: 15
view all 3 authors...
#1Lotte GeysH-Index: 4
#2Elien RooseH-Index: 8
Last. Ilse ScroyenH-Index: 15
view all 6 authors...