Małgorzata Starek
Jagiellonian University Medical College
Detection limitDensitometryDegradation (geology)ChemistryThin-layer chromatographyLipophilicityAcetic acidIsoxicamCefuroximePiroxicamSilica gelMethanolAlkaline hydrolysis (body disposal)ChromatographyCephalosporinMedicineImpurityQuantitative analysis (chemistry)Cancer cellAbsorbance
55Publications
10H-index
336Citations
Publications 61
Newest
The formation of cefuroxime axetil+cyclodextrin (CA+CD) complexes increases the aqueous solubility of CA, improves its physico-chemical properties, and facilitates a biomembrane-mediated drug delivery process. In CD-based tablet formulations, it is crucial to investigate the molecular details of complexes in final pharmaceutical preparation. In this study, Raman spectroscopy and mapping were applied for the detection and identification of chemical groups involved in α-, β-, γ-, and 2-hydroxyprop...
Source
#1Małgorzata StarekH-Index: 10
#2Monika DąbrowskaH-Index: 6
Last. Paweł GumułkaH-Index: 1
view all 3 authors...
Source
#1Aneta Kaczor (Jagiellonian University)
#2Nikoletta Szemerédi (University of Szeged)H-Index: 1
Last. Jadwiga Handzlik (Jagiellonian University)H-Index: 9
view all 8 authors...
ABCB1 modulation is an interesting strategy in search for new anticancer agents overcoming multidrug resistance (MDR). Hence, 17 new 5-arylideneimidazolones containing amine moiety, as potential ABCB1 inhibitors was designed, synthesized, and investigated. The series was tested in both, parental (PAR) and multidrug resistant (MDR) overproducing ABCB1, T-lymphoma cancer cells using cytotoxicity assay. The ABCB1 modulating activity was examined in the rhodamine 123 accumulation test, followed by P...
Source
#2Małgorzata StarekH-Index: 10
Last. Monika DąbrowskaH-Index: 6
view all 4 authors...
Currently, there is still a need for broad-spectrum antibiotics. The new cephalosporin antibiotics include, among others, ceftobiprole, a fifth-generation gram-positive cephalosporin, active against Staphylococcus aureus methicillin agonist (MRSA). The main focus of the work was to optimize the conditions of ceftobiprole qualitative determination and to validate the developed procedure according to ICH guidelines. As a result of the optimization process, HPTLC Cellulose chromatographic plates as...
Source
#1Małgorzata StarekH-Index: 10
Last. Monika DąbrowskaH-Index: 6
view all 4 authors...
Lipophilicity study of selected NSAIDs, the group of the bioactive compounds usually used in humans and animals medicine, with the use of experimental and calculation methods was evaluated. LogP values are proposed and compared as descriptors of the lipophilicity of eleven compounds (from oxicams and coxibs). Obtained data were designated by thin-layer chromatography (TLC) in various chromatographic conditions, with stationary phases with different properties. The mobile phase systems were prepa...
Source
#1Małgorzata Starek (Jagiellonian University Medical College)H-Index: 10
#2Justyna Mierzwa (Jagiellonian University Medical College)
Last. Monika Dąbrowska (Jagiellonian University Medical College)H-Index: 6
view all 4 authors...
Nowadays, topics related to the proper nutrition of the body, which requires a complex of compounds and supplementation of these ingredients have undoubtedly gained popularity, so it should come as...
Source
#1Paweł GumułkaH-Index: 1
#2Monika DąbrowskaH-Index: 6
Last. Małgorzata StarekH-Index: 10
view all 3 authors...
Source
#1Wesam Ali (Saarland University)H-Index: 5
#2Gabriella Spengler (University of Szeged)H-Index: 25
Last. Jadwiga Handzlik (Jagiellonian University Medical College)H-Index: 19
view all 15 authors...
Abstract Multidrug resistance (MDR) in cancer cells is a crucial aspect to consider for a successful cancer therapy. P-gp/ABCB1, a member of ABC transporters, is involved in the main tumour MDR mechanism, responsible for the efflux of drugs and cytotoxic substances. Herein, we describe a discovery of potent selenium-containing ABCB1 MDR efflux pump modulators with promising anticancer activity. On three groups of selenoethers comprehensive studies in terms of design, synthesis, and biological as...
4 CitationsSource
#1Paweł GumułkaH-Index: 1
#2Monika DąbrowskaH-Index: 6
Last. Małgorzata StarekH-Index: 10
view all 3 authors...
A class of drugs called coxibs (COX-2 inhibitors) were created to help relieve pain and inflammation of osteoarthritis and rheumatoid arthritis with the lowest amount of side effects possible. The presented paper describes a new developed, optimized and validated thin layer chromatographic (TLC)-densitometric procedure for the simultaneous assay of five coxibs: celecoxib, etoricoxib, firecoxib, rofecoxib and cimicoxib. Chromatographic separation was conducted on HPTLC F254 silica gel chromatogra...
Source