Simon R. Cherry
University of California, Davis
Imaging phantomPhotomultiplierOpticsPhysicsBiomedical engineeringIterative reconstructionArtificial intelligenceScintillatorMaterials scienceImage resolutionPositron emission tomographyScannerPreclinical imagingNuclear medicineComputer scienceResolution (electron density)MedicineBiologyDetector
454Publications
93H-index
24.4kCitations
Publications 450
Newest
#1Junwei Du (UC Davis: University of California, Davis)H-Index: 11
#2Qian Wang (UC Davis: University of California, Davis)H-Index: 1
Last. Simon R. Cherry (UC Davis: University of California, Davis)H-Index: 93
view all 5 authors...
OBJECTIVE Dual-ended readout depth-encoding detectors based on bismuth germanate (BGO) scintillation crystal arrays are good candidates for high-sensitivity small animal positron emission tomography used for very-low-dose imaging. In this paper, the performance of three dual-ended readout detectors based on 15 × 15 BGO arrays with three different reflector arrangements and 8 × 8 silicon photomultiplier arrays were evaluated and compared. APPROACH The three BGO arrays, denoted wo-ILG (without int...
Source
#1Edwin Leung (UC Davis: University of California, Davis)H-Index: 3
#2Eric Berg (UC Davis: University of California, Davis)H-Index: 14
Last. Songsong TangH-Index: 2
view all 15 authors...
Absolute quantification of regional tissue concentration of radioactivity in positron emission tomography (PET) is a critical parameter-of-interest across various clinical and research applications and is affected by a complex interplay of factors including scanner calibration, data corrections, and image reconstruction. The emergence of long axial field-of-view (FOV) PET systems widens the dynamic range accessible to PET and creates new opportunities in reducing scan time and radiation dose, de...
Source
#1Yiran Wang (UC Davis: University of California, Davis)
#2Elizabeth Li (UC Davis: University of California, Davis)H-Index: 1
Last. Guobao Wang (UC Davis: University of California, Davis)H-Index: 17
view all 4 authors...
The uEXPLORER total-body PET/CT system provides a very high level of detection sensitivity and simultaneous coverage of the entire body for dynamic imaging for quantification of tracer kinetics. This article describes the fundamentals and potential benefits of total-body kinetic modeling and parametric imaging focusing on the noninvasive derivation of blood input function, multiparametric imaging, and high-temporal resolution kinetic modeling. Along with its attractive properties, total-body kin...
Source
Enhancing photon detection efficiency and time resolution in photodetectors in the entire visible range is critical to improve the image quality of time-of-flight (TOF)-based imaging systems and fluorescence lifetime imaging (FLIM). In this work, we evaluate the gain, detection efficiency, and timing performance of avalanche photodiodes (APD) with photon trapping nanostructures for photons with 450 nm and 850 nm wavelengths. At 850 nm wavelength, our photon trapping avalanche photodiodes showed ...
2 CitationsSource
#1Nicolas Aide (French Institute of Health and Medical Research)H-Index: 28
#2Charline Lasnon (French Institute of Health and Medical Research)H-Index: 12
Last. Daniel R. McGowan (Churchill Hospital)H-Index: 13
view all 11 authors...
1 CitationsSource
#1Benjamin Spencer (UC Davis: University of California, Davis)H-Index: 5
#2Eric Berg (UC Davis: University of California, Davis)H-Index: 14
Last. Simon R. Cherry (UC Davis: University of California, Davis)H-Index: 93
view all 16 authors...
The world’s first total-body PET scanner with an axial field-of-view (AFOV) of 194 cm is now in clinical and research use at our institution. The uEXPLORER PET/CT scanner, developed through a collaboration between the University of California, Davis (UC Davis) and United Imaging Healthcare (UIH), is the first commercially available total-body PET scanner. Here we present a detailed physical characterization of the uEXPLORER PET scanner based on NEMA NU-2-2018 along with a new set of measurements...
19 CitationsSource
#1Ryosuke Ota (Hamamatsu Photonics)H-Index: 10
#2Sun Il Kwon (UC Davis: University of California, Davis)H-Index: 13
Last. Simon R. Cherry (UC Davis: University of California, Davis)H-Index: 93
view all 10 authors...
Positron emission tomography, like many other tomographic imaging modalities, relies on an image reconstruction step to produce cross-sectional images from projection data. Detection and localization of the back-to-back annihilation photons produced by positron-electron annihilation defines the trajectories of these photons, which when combined with tomographic reconstruction algorithms, permits recovery of the distribution of positron-emitting radionuclides. Here we produce cross-sectional imag...
1 Citations
#1Tao FengH-Index: 9
#2Yizhang ZhaoH-Index: 1
Last. Terry L. Jones (UC Davis: University of California, Davis)H-Index: 30
view all 10 authors...
Parametric imaging has been shown to provide better quantitation physiologically compared with SUV imaging in PET. With the increased sensitivity from a recently developed total-body PET scanner, whole-body scans with higher temporal resolution become possible for dynamic analysis and parametric imaging. In this paper, we focus on deriving the parameter k1 using compartmental modeling, and on developing a method to acquire whole-body FDG-PET parametric images using only the first 90 seconds of t...
9 CitationsSource
#1Yasser Abdelhafez (UC Davis: University of California, Davis)H-Index: 5
#2Heather Hunt (UC Davis: University of California, Davis)H-Index: 1
Last. Abhijit J. Chaudhari (UC Davis: University of California, Davis)H-Index: 18
view all 10 authors...
1697 Purpose: Total-body PET/CT scanners offer the unique ability to evaluate the systemic inflammatory burden of autoimmune inflammatory arthritic (AIA) conditions using ultra-low dose protocols. However, AIA patients are unable to tolerate long scan times. We prospectively evaluated the influence of shortening the scan time on image quality in participants with AIA and non-AIA controls using a total-body PET/CT scanner. Methods: Participants with an established AIA condition (Rheumatoid Arthri...
#1Yasser Abdelhafez (UC Davis: University of California, Davis)H-Index: 5
#2Fatma Sen (UC Davis: University of California, Davis)
Last. Lorenzo Nardo (UC Davis: University of California, Davis)H-Index: 29
view all 8 authors...
1680 Purpose: The 60 min uptake protocol for oncological 18F-FDG PET imaging has been standard of care since the 1990s. The protocol was primarily determined by factors including the sensitivity of the scanners of the era and the necessity of performing transmission scans prior to the injection of radiotracer. Subsequently, post-injection transmission or CT scanning were adopted, delayed imaging has been demonstrated to improve lesion detectability and characterization of findings in a wide rang...