Oded Langer
Mount Sinai St. Luke's and Mount Sinai Roosevelt
Internal medicineObstetricsEndocrinologySurgeryFetusIntensive care medicinePediatricsProspective cohort studyGestational agePregnancyInsulinGestational diabetesShoulder dystociaGlycemicGlucose tolerance testGynecologyGestationObesityDiabetes mellitusMedicine
Publications 246
The obesity and diabetes epidemic is an unintended consequence of economic, social, and technological changes. In nonpregnancy, people identified as high risk to develop type 2 diabetes may delay progression by 30–70% with lifestyle interventions and pharmacological agents. In pregnancy, lifestyle interventions have been the primary focus to prevent fetal short- and long-term complications that may evolve into substantial weight gain and gestational diabetes mellitus. The dilemma for obstetricia...
5 CitationsSource
Controversies persist over the most efficacious pharmacologic treatment for gestational diabetes mellitus. For purposes of accuracy in this article, the individual American College of Obstetricians and Gynecologists Practice Bulletin and American Diabetes Association Standards of Medical Care positions on each issue are quoted and then deliberated with evidence of counter claims presented in point/counterpoint. This is a review of all the relevant evidence for the most holistic picture possible....
10 CitationsSource
#1Julie A. Rosen (UMB: University of Maryland, Baltimore)H-Index: 1
#2Oded LangerH-Index: 58
Last. Menachem Miodovnik (NIH: National Institutes of Health)H-Index: 52
view all 4 authors...
The Diabetes in Pregnancy Study Group of North America (DPSG-NA) was founded in 1997 in San Antonio, Texas, out of the recognition that the field of maternal–fetal medicine should support and conduct research to address the specialized needs of pregnant women with type 1, type 2, or gestational diabetes mellitus. Since its inception, the DPSG-NA meetings have become a vehicle for the dissemination of data, gathered through collaboration among basic, translational, and clinical researchers and ca...
1 CitationsSource
#1Lois Brustman (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 6
#2Oded Langer (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 58
Last. Manal El Daouk (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 4
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AbstractObjective: To evaluate treatment effectiveness (diet alone, insulin or glyburide) on maternal weight gain in gestational diabetes (GDM).Methods: GDM patients were treated with diet alone, insulin or glyburide. Weight gain was stratified into: prior to GDM diagnosis, from diagnosis to delivery and total pregnancy weight gain. Good glycemic control was defined as mean blood glucose ≤105 mg/dl and obesity as Body Mass Index (BMI) ≥ 30 kg/m2, overweight BMI 25–29 kg/m2 and normal < 25 kg/m2....
8 CitationsSource
AbstractObjective: To examine impact on perinatal outcome of untreated gestational diabetes (GDM) and non-diabetics stratified by body mass index (BMI).Research design and methods: This is a secondary analysis of our investigation of the consequences of not treating GDM. We evaluated 555 untreated GDMs matched to 1100 non-diabetics. BMI was determined using subjects’ recalled pre-pregnancy weight. A primary composite variable consisted of stillbirth, neonatal macrosomia/large-for-gestational-age...
14 CitationsSource
: Lowering glucose is of pivotal importance in the treatment of diabetes in pregnancy. A spectrum of different glucose thresholds can be established and used appropriately to prevent each complication. This article outlines the concept of normality and what definition of normality should be used to evaluate the relationship between the level of glycemia and perinatal outcome.
9 CitationsSource
#1Oded LangerH-Index: 58
#2Jason G. Umans (MedStar Health)H-Index: 28
Last. Menachem Miodovnik (Georgetown University)H-Index: 52
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The new criteria for diagnosis of gestational diabetes mellitus proposed by the International Association of Diabetes in Pregnancy Study Group (IADPSG) transports back the controversy and the lack of agreement to the frontlines. The recommended criteria are based on results of the observational hyperglycemia and adverse pregnancy outcome study (HAPO). These criteria will increase the frequency of gestational diabetes diagnosis by 2–8 folds, depending upon ethnicity, and prevalence of obesity. Do...
22 CitationsSource
#1Oded LangerH-Index: 58
#2Jason G. UmansH-Index: 28
Last. Menachem MiodovnikH-Index: 78
view all 3 authors...
To date, The International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria for the diagnosis of gestational diabetes mellitus (GDM) have not been analyzed systematically for medical, social, and economic ramifications if used in substitution for the current GDM diagnostic criteria. The IADPSG dependence on expert opinion and consensus rather than on rigorously obtained outcome measures is concerning given the dramatic changes in clinical intervention and medical-resource...
27 CitationsSource
#1Orli MostH-Index: 3
#2Oded Langer (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 58
Objectives: We sought to determine the impact of maternal weight gain on fetal growth in gestational diabetes (GDM) in relation to treatment modality, body mass index (BMI) and glycemic control. Study design: Two thousand four hundred fifty-four GDMs were evaluated. Obesity was defined as BMI >29; good glycemic control ≤100 mg/dl; maternal age 30 years; parity ±1; large for gestational age (LGA) >90th percentile and small for gestational age (SGA) <10th percentile. Results: SGA rates were simila...
24 CitationsSource
#1Robert L. Andres (UofU: University of Utah)H-Index: 16
#2Yuan Zhao (GW: George Washington University)H-Index: 7
Last. Oded Langer (UTSA: University of Texas at San Antonio)H-Index: 58
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Preterm premature rupture of the membranes (pPROM) occurs in 0.7 to 3.0% of all pregnancies and has been implicated in 30% of preterm deliveries.1–3 The perinatal morbidity linked to this event is directly related to the gestational age at delivery. In addition to the risks inherent in prematurity (e.g., respiratory distress syndrome, intraventricular hemorrhage, and necrotizing enterocolitis), pregnancies complicated by pPROM are at an increased risk for intra-amniotic infection, neonatal sepsi...
1 CitationsSource