Nina Øyen
Statens Serum Institut
EpidemiologyOffspringInternal medicineObstetricsDemographyOdds ratioPediatricsCohort studyBirth orderPregnancyFamily historyPopulationSudden infant death syndromeSudden deathConfidence intervalRisk factorNorwegianBirth weightMedicineCohortRelative risk
Publications 102
#1Jonas Ghouse (Copenhagen University Hospital)H-Index: 9
#2O Voegg (Gentofte Hospital)
Last. Heather A. Boyd (SSI: Statens Serum Institut)H-Index: 40
view all 15 authors...
#1Trude Gildestad (University of Bergen)H-Index: 3
#2Tone Bjørge (University of Bergen)H-Index: 59
Last. Nina Øyen (University of Bergen)H-Index: 36
view all 6 authors...
The association between folic acid supplementation and birth defects other than neural tube defects remains unclear. We used a log-binomial regression model to investigate if periconceptional folic acid and/or multivitamin use was associated with birth defects in Norway with prospectively collected data from the Medical Birth Registry of Norway (MBRN) during 1999-2013. We used the EUROCAT classification system to define 11 organ-specific major birth defect groups (nervous system, eye, ear-face-n...
3 CitationsSource
#1Amalie Bøggild Schmidt (SSI: Statens Serum Institut)
#2Marie Lund (SSI: Statens Serum Institut)H-Index: 11
Last. Mads Melbye (Stanford University)H-Index: 126
view all 6 authors...
BACKGROUND: Pre-pregnancy diabetes is a strong risk factor for congenital heart defects (CHDs), suggesting a role for glucose in the causal pathway. Oral corticosteroids may cause hyperglycemia and maternal use could affect embryonic heart development. The objective of this study was to determine the association between maternal intake of oral corticosteroids 0-8 weeks after conception and CHDs in offspring. METHODS: A register-based nationwide prevalence study including all live singleton birth...
#1Amalie Bøggild Schmidt (SSI: Statens Serum Institut)
#2Marie Lund (SSI: Statens Serum Institut)H-Index: 11
Last. Mads Melbye (Stanford University)H-Index: 126
view all 8 authors...
BACKGROUND: Prepregnancy diabetes, especially when severely dysregulated, is associated with an increased risk of congenital heart defects in offspring. This suggests that glucose plays a role in embryonic heart development. OBJECTIVE: The aim was to investigate the association between midpregnancy dietary glycemic index (GI), glycemic load (GL), and sugar-sweetened beverages and the risk of congenital heart defects in the offspring. METHODS: Offspring of mothers from the Danish National Birth C...
1 CitationsSource
#1Nina Øyen (University of Bergen)H-Index: 36
#2Sjurdur F. Olsen (SSI: Statens Serum Institut)H-Index: 69
Last. Mads Melbye (Stanford University)H-Index: 126
view all 12 authors...
Background Evidence linking individual‐level maternal folic acid supplementation to offspring risk of congenital heart defects is lacking. We investigated whether folic acid supplementation in earl...
15 CitationsSource
#1Maria T. Grønning Dale (University of Oslo)H-Index: 8
#1Maria Dale (University of Oslo)H-Index: 9
Last. Nina Øyen (University of Bergen)H-Index: 36
view all 9 authors...
Studies report increased risk of congenital heart defects (CHD) in the offspring of mothers with diabetes, where high blood glucose levels might confer the risk. We explored the association between intake of sucrose-sweetened soft beverages during pregnancy and risk of CHD. Prospective cohort data with 88,514 pregnant women participating in the Norwegian Mother and Child Cohort Study was linked with information on infant CHD diagnoses from national health registers and the Cardiovascular Disease...
11 CitationsSource
#1Anders Husby (Stanford University)H-Index: 5
#2Jan Wohlfahrt (SSI: Statens Serum Institut)H-Index: 72
Last. Mads Melbye (Stanford University)H-Index: 126
view all 4 authors...
Full-term pregnancies reduce a woman’s long-term breast cancer risk, while abortions have been shown to have no effect. The precise minimal duration of pregnancy necessary to lower a woman’s breast cancer risk is, however, unknown. Here we provide evidence which point to the protective effect of pregnancy on breast cancer risk arising precisely at the 34th pregnancy week. Using a cohort of 2.3 million Danish women, we found the reduction in breast cancer risk was not observed for pregnancies las...
20 CitationsSource
#1Jan Helge Seglem Mortensen (University of Bergen)H-Index: 9
#2Nina Øyen (University of Bergen)H-Index: 36
Last. Tone Bjørge (University of Bergen)H-Index: 59
view all 6 authors...
Background Maternal predictors of folic acid (FA) supplementation use to reduce offspring risk of neural tube defects are well known, while paternal determinants for maternal FA use are less known. Such knowledge is important to increase women’s compliance to recommended periconceptional FA use.
2 CitationsSource
#1Kristoffer Brodwall (University of Bergen)H-Index: 7
#2Gottfried Greve (University of Bergen)H-Index: 13
Last. Nina Øyen (University of Bergen)H-Index: 36
view all 7 authors...
AIM: We investigated the prevalence of Down syndrome in a nationwide birth cohort, focusing on congenital heart defects (CHDs), their associations with extracardiac malformations (ECM) and survival. METHODS: National registers were used to identify Norwegian births (1994-2009) and deaths (1994-2014) and updated with hospital diagnoses. We estimated birth defect frequencies in Down syndrome and the general population, the association between CHDs and ECM and hazard ratios for death from different...
10 CitationsSource
#1Heather A. Boyd (SSI: Statens Serum Institut)H-Index: 40
#2Saima Basit (SSI: Statens Serum Institut)H-Index: 12
Last. Nina Øyen (University of Bergen)H-Index: 36
view all 4 authors...
We thank Ziliang Ye and colleagues for their comments on our article, in which we reported associations between offspring congenital heart defects and maternal hypertensive disorders of pregnancy.1 They suggest 3 possible limitations that may have weakened our study. We contend that, although our study undoubtedly had limitations, those mentioned by Ye et al are not among them. First, Ye et al argue that our results may have been confounded by medication use, specifically the use of folic acid a...