Pierangela Totta
Roma Tre University
EndocrinologyEstrogen receptor alphaChemistryApoptosisPlatelet lysateStem cellBiochemistryMAPK/ERK pathwayCell growthSignal transductionProtein kinase BEndocytic cycleIntracellularEstrogen receptorPI3K/AKT/mTOR pathwayBiologyMitosisCell biologyCancer cellEstrogen receptor beta
Publications 35
#1Annarita Favia (National Research Council)H-Index: 8
#2Luisa Salvatori (National Research Council)H-Index: 17
Last. Barbara Illi (National Research Council)H-Index: 21
view all 11 authors...
Protein Arginine (R) methylation is the most common post-translational methylation in mammalian cells. Protein Arginine Methyltransferases (PRMT) 1 and 5 dimethylate their substrates on R residues, asymmetrically and symmetrically, respectively. They are ubiquitously expressed and play fundamental roles in tumour malignancies, including glioblastoma multiforme (GBM) which presents largely deregulated Myc activity. Previously, we demonstrated that PRMT5 associates with Myc in GBM cells, modulatin...
8 CitationsSource
#1Rita Businaro (Sapienza University of Rome)H-Index: 18
#2Eleonora Scaccia (Sapienza University of Rome)H-Index: 2
Last. Elena De Falco (Sapienza University of Rome)H-Index: 18
view all 14 authors...
Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets, which are source of clinical hemoderivates, such as platelet lysate (PL), routinely employed in several clinical applications as wound healing, and to preserve ex vivo the progenitor properties of the adipose stromal cells pool. So far, the pres...
8 CitationsSource
#1Maria Teresa Nuzzo (Roma Tre University)H-Index: 5
#2Marco Fiocchetti (Roma Tre University)H-Index: 12
Last. Maria Marino (Roma Tre University)H-Index: 34
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Among several mechanisms underlying the well-known trophic and protective effects of 17β-estradiol (E2) in the brain, we recently reported that E2 induces the up-regulation of two anti-apoptotic and neuroprotectant proteins: huntingtin (HTT) and neuroglobin (NGB). Here, we investigate the role of this up-regulation. The obtained results indicate that E2 promotes NGB-HTT association, induces the localization of the complex at the mitochondria, and protects SK-N-BE neuroblastoma cells and murine s...
14 CitationsSource
#1Raffaella FazzinaH-Index: 8
#2Paola IudiconeH-Index: 10
Last. Luca Pierelli (Sapienza University of Rome)H-Index: 33
view all 7 authors...
Background Mesenchymal stromal cells (MSCs) have been largely investigated, in the past decade, as potential therapeutic strategies for various acute and chronic pathological conditions. MSCs isolated from different sources, such as bone marrow (BM), umbilical cord tissue (UCT) and adipose tissue (AT), share many biological features, although they may show some differences on cumulative yield, proliferative ability and differentiation potential. The standardization of MSCs growth and their funct...
21 CitationsSource
#1Pierangela TottaH-Index: 16
#2Fabio GionfraH-Index: 1
Last. Filippo AcconciaH-Index: 30
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The sex hormone 17β-estradiol (E2) exerts pleiotropic effects by binding to the ligand-activated transcription factor estrogen receptor α (ERα). The E2:ERα complex regulates several physiological processes, including cell survival and proliferation, through transcriptional effects (i.e., estrogen responsive element [ERE]-based gene transcription) and non-transcriptional membrane-initiated effects (i.e., the activation of extra-nuclear signaling cascades), which derive from the activation of the ...
17 CitationsSource
#1Pierangela TottaH-Index: 16
#2Claudia BusoneroH-Index: 8
Last. Filippo AcconciaH-Index: 30
view all 5 authors...
17β-estradiol (E2) regulates diverse physiological effects, including cell proliferation, by binding to estrogen receptor α (ERα). ERα is both a transcription factor that drives E2-sensitive gene expression and an extra-nuclear localized receptor that triggers the activation of diverse kinase cascades. While E2 triggers cell proliferation, it also induces ERα degradation in a typical hormone-dependent feedback loop. Although ERα breakdown proceeds through the 26S proteasome, a role for lysosomes...
21 CitationsSource
#1Valeria PesiriH-Index: 7
#2Pierangela TottaH-Index: 16
Last. Filippo AcconciaH-Index: 30
view all 7 authors...
Abstract 17β-Estradiol (E2)-dependent cell proliferation requires both estrogen receptor α (ERα)-based integrated control of gene transcription and kinase pathways activation. Such coordination of intracellular E2:ERα-dependent signaling mechanisms is finely tuned by receptor association with specific partner proteins. Recently, we identified the leucine (L) 429 and alanine (A) 430 within the ERα ligand binding domain as important residues for receptor non-covalent interaction to ubiquitinated s...
13 CitationsSource
#1M Orticello (National Research Council)H-Index: 1
#2Mario Fiore (National Research Council)H-Index: 5
Last. Francesca Degrassi (National Research Council)H-Index: 30
view all 12 authors...
N-terminus-modified Hec1 suppresses tumour growth by interfering with kinetochore–microtubule dynamics
8 CitationsSource
#1Pierangela TottaH-Index: 16
#2Valeria PesiriH-Index: 7
Last. Filippo AcconciaH-Index: 30
view all 5 authors...
17β-estradiol (E2)-induced signaling and control of estrogen receptor (ER)α degradation both play a major role in breast cancer cell proliferation. We recently reported the involvement of lysosomal function in both E2-dependent ERα breakdown and E2-induced cell proliferation and thus hypothesized a role for endocytic proteins in ERα signaling. An small interfering RNA screen identified proteins that regulate intracellular endocytic traffic and whose silencing alters E2-induced ERα degradation. O...
14 CitationsSource
1 CitationsSource
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