Alexander Marx
Heidelberg University
CancerPathologyOncologyAntigenMolecular biologyAutoantibodyEpitopeImmunologyImmunohistochemistryThymic carcinomaMyasthenia gravisThymomaLymphomaThymectomyAutoimmunityCancer researchMedicineAcetylcholine receptorBiologyCell biology
Publications 402
#1Thierry Jo Molina (University of Paris)H-Index: 22
#2M.V. BluthgenH-Index: 5
Last. Benjamin BesseH-Index: 54
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#1Lara ChalabreysseH-Index: 17
#2Romain DuboisH-Index: 3
Last. Thierry Jo Molina (University of Paris)H-Index: 22
view all 16 authors...
#1Sven Burgdorf (University of Bonn)H-Index: 25
#2Stefan Porubsky (University of Mainz)H-Index: 22
Last. Zoran V. Popovic (Heidelberg University)H-Index: 5
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1 CitationsSource
#1Janina L. Wolf (EUR: Erasmus University Rotterdam)
Last. Michael A. den Bakker (EUR: Erasmus University Rotterdam)H-Index: 31
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AIMS Thymic tumours are rare in routine pathology practice. Although the World Health Organization (WHO) classification describes a number of well-defined categories, the classification remains challenging. The aim of this study was to investigate the reproducibility of the WHO classification among a large group of international pathologists with expertise in thymic pathology and by using whole slide imaging to facilitate rapid diagnostic turnover. METHODS AND RESULTS Three hundred and five tumo...
#1Shunta Ishihara (Kyoto Prefectural University of Medicine)H-Index: 2
#2Satoru Okada (Kyoto Prefectural University of Medicine)H-Index: 5
Last. Masayoshi Inoue (Kyoto Prefectural University of Medicine)H-Index: 31
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Abstract Objectives Whether the extent of expression of programmed death-ligand 1 (PD-L1) is clinically significant remains uncertain, although immuno-oncological features have been studied in thymic epithelial cell tumors (TETs). We investigated the histological features of PD-L1 expression in TETs, and assessed PD-L1 expression using digital image analysis. Materials and Methods Participants comprised 66 patients with TET who underwent surgical resection between 2001 and 2016. We calculated tu...
#1Yosuke Yamada (Heidelberg University)
#2Cleo-Aron Weis (Heidelberg University)H-Index: 11
Last. Alexander Marx (Heidelberg University)H-Index: 51
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A unique feature of thymomas is their unrivaled frequency of associated myasthenia gravis (MG). Previous studies reported that MG+ thymomas contain a larger number of mature "pre-emigrant" CD4+ T cells than MG- thymomas and that most thymomas do not contain AIRE expressing cells irrespective of MG status. These findings suggest that CD4+ T cells that mature inside the abnormal microenvironment of thymomas and egress to the blood are critical to the development of thymoma-associated MG (TAMG) irr...
1 CitationsSource
#1Shuiping Yin (Anhui Medical University)H-Index: 5
#2Nan Wang (TJMC: Tongji Medical College)H-Index: 3
Last. Julia Kzhyshkowska (Tomsk State University)H-Index: 37
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: Chitinase-like proteins (CLP) are chitin-binding proteins that lack chitin hydrolyzing activity, but possess cytokine-like and growth factor-like properties, and play crucial role in intercellular crosstalk. Both human and mice express two members of CLP family: YKL-40 and stabilin-1 interacting chitinase-like protein (SI-CLP). Despite numerous reports indicating the role of YKL-40 in the support of angiogenesis, tumor cell proliferation, invasion and metastasis, the role of its structurally r...
6 CitationsSource
#1Stefan Porubsky (Heidelberg University)H-Index: 22
#2Peter Jessup (Royal Hobart Hospital)H-Index: 3
Last. Alexander Marx (Heidelberg University)H-Index: 51
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Our aim was to investigate sebaceous differentiation in thymus tumours and to identify new actionable genomic alterations. To this end we screened 35 normal and 23 hyperplastic thymuses, 127 thymomas and 41 thymic carcinomas for the presence of sebaceous differentiation as defined by morphology and expression of adipophilin and androgen receptor (AR). One primary thymic carcinoma showed morphology of sebaceous carcinomas (keratinizing and foam cells, calcifications, giant cells), a strong expres...
#1Alexander Marx (Heidelberg University)H-Index: 51
The chapter on Nonneoplastic Thymic Lesions will cover the epidemiological, etiological and clinicopathological features of common thymic lesions (congenital and acquired cysts, including dysplasia); thymic follicular, rebound and “true” hyperplasia) as well as rare or recently described non-neoplastic thymic alterations that may form mass lesions and can mimic thymic neoplasms (“Lesa-like thymic hyperplasia”; “Cholesteroloma”; Fibrosing mediastinitis, including IgG4-related disease). Criteria c...
#1Tao Lin (Heidelberg University)H-Index: 2
#2S Wang (Capital Medical University)H-Index: 2
Last. Honglei Weng (Heidelberg University)H-Index: 25
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