Christian Hölscher
Shanxi Medical University
Insulin receptorEndocrinologyHippocampal formationNeuroscienceReceptorChemistryLong-term potentiationNeuroprotectionNeurodegenerationIncretinAgonistDiseaseInsulinParkinson's diseaseHippocampusLiraglutideMedicineBiologySynaptic plasticityPharmacology
Publications 245
#1Lin Li (Shanxi Medical University)H-Index: 20
#2Lingyu Zhang (Shanxi Medical University)H-Index: 3
Last. Christian Hölscher (Shanxi Medical University)H-Index: 60
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Patients with Parkinson's disease (PD) have impaired insulin signaling in the brain. Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), can re-sensitize insulin signaling. In a recent phase II clinical trial, the first GLP-1 mimic, exendin-4, has shown reliable curative effect in patients with PD. DA-CH5 is a novel GLP-1/GIP receptor unimolecular co-agonist with a novel peptide sequence added to cross the blood-brain barrier. Here...
1 CitationsSource
Type 2 diabetes (T2DM) and the associated de-sensitisation of insulin signalling has been identified as a risk factor for progressive neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), and others. Glucagon-like protein 1 (GLP-1) is a hormone that has growth-factor like and neuroprotective properties. Several clinical trials have been conducted, testing GLP-1R agonists in patients with AD, PD, or diabetes-induced memory impairments. The trials showed clear imp...
#1Grazia Daniela Femminella (Imperial College London)H-Index: 23
#2Nicholas R Livingston (Imperial College London)
Last. Paul Edison (Imperial College London)H-Index: 30
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BACKGROUND Type 2 diabetes is a risk factor for Alzheimer's disease (AD), and AD brain shows impaired insulin signalling. The role of peripheral insulin resistance on AD aetiopathogenesis in non-diabetic patients is still debated. Here we evaluated the influence of insulin resistance on brain glucose metabolism, grey matter volume and white matter lesions (WMLs) in non-diabetic AD subjects. METHODS In total, 130 non-diabetic AD subjects underwent MRI and [18F]FDG PET scans with arterial cannula ...
#1Gao Gai (Henan University)H-Index: 1
#2Xie Zhishen (Henan University)H-Index: 2
Last. Zhenqiang Zhang (Henan University)H-Index: 3
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The accumulation of iron-dependent lipid peroxides is one of the important causes of NAFLD. The purpose of this study is to explore the effect of dehydroabietic acid (DA) on ferroptosis in nonalcoholic fatty liver disease (NAFLD) mice and its possible mechanisms. DA improved NAFLD and reduced triglycerides (TG), total cholesterol (TC), and lipid peroxidation level and inhibited ferroptosis in the liver of HFD-induced mice. DA binds with Keap1 to form 3 stable hydrogen bonds at VAL512 and LEU557 ...
#1Bo Bai (Shanxi Medical University)
#2Dongfang Li (Shanxi Medical University)H-Index: 8
Last. Christian Hölscher (Shanxi Medical University)H-Index: 60
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Abstract Background and aims Diabetes is one of the most important risk factors and comorbidities of ischemic stroke. Endoplasmic reticulum stress (ERS) is considered to be the major injury mechanism of ischemic stroke with diabetes. Studies have found that incretin can inhibit ERS in ischemia-reperfusion injury of the liver and heart. We aimed to explore the effects of GLP-1/GIP double agonist DA3-CH and GLP-1 single agonist liraglutide on ERS and apoptosis in diabetic rats with cerebral ischem...
#2Zijuan Zhang (Henan University)H-Index: 1
Last. Christian Hölscher (Shanxi Medical University)H-Index: 60
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Glucagon-like peptide-2 (GLP-2) is a peptide hormone that belongs to the glucagon-derived peptide family. We have previously shown that analogues of the sister hormone Glucagon-like peptide-1 (GLP-1) showed neuroprotective effects. Here we investigated the effect of a GLP-2 agonist in a cell model of Parkinson's disease (PD) created by treating SH-SY5Y or Neuro-2a cells with 1-Methyl-4-phenyl-pyridine ion (MPP+). Cell viability and cell cytotoxicity was detected by MTT and LDH assays, respective...
1 CitationsSource
#1Mark Maskery (Lancaster University)H-Index: 1
#2Christian Hölscher (Henan University)H-Index: 60
Last. Hedley C. A. Emsley (Lancaster University)H-Index: 27
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Stroke mortality and morbidity is expected to rise. Despite considerable recent advances within acute ischemic stroke treatment, scope remains for development of widely applicable neuroprotective agents. Glucagon like peptide-1 receptor agonists (GLP-1RAs), originally licensed for the management of Type 2 Diabetes Mellitus, have demonstrated pre-clinical neuroprotective efficacy in a range of neurodegenerative conditions. This systematic scoping review reports the pre-clinical basis of GLP-1RAs ...
3 CitationsSource
#1Zijuan Zhang (Henan University)H-Index: 1
#2Hao Li (Henan University)
Last. Christian Hölscher (Henan University)H-Index: 60
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Parkinson's disease (PD) is a chronic neurodegenerative disease, and there is no cure for it at present. Recent research has indicated a link between type 2 diabetes mellitus (T2DM) and PD, which suggested that a treatment to improve insulin resistance for T2DM may be useful for PD patients. Glucose-dependent insulinotropic polypeptide (GIP) belongs to the incretin hormone family, which can promote insulin release and improve insulin resistance. Several GIP analogues have been developed as poten...
#1Li Yuan (Changzhi Medical College)H-Index: 9
#2Jun Zhang (Shanxi Medical University)H-Index: 9
Last. Jin-Shun Qi (Shanxi Medical University)H-Index: 19
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BACKGROUND Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive decline in cognitive function. Type 2 diabetes mellitus (T2DM) is an important risk factor for AD. Glucose-dependent insulinotropic polypeptide (GIP) has been identified to be effective in T2DM treatment and neuroprotection. OBJECTIVE The present study investigated the neuroprotective effects and possible mechanisms of DAla2GIP-Glu-PAL, a novel long-lasting GIP analogue, in APP/PS1 AD mice. METHODS Mu...