Gary R. Matyas
Walter Reed Army Institute of Research
Lipid AAntigenMolecular biologyVirologyAntibodyLiposomeChemistryEpitopeImmunologyVirusToxoidAdjuvantImmunogenicityMonophosphoryl Lipid AHaptenMonoclonal antibodyBiochemistryMedicineBiologyImmune system
112Publications
31H-index
2,523Citations
Publications 112
Newest
#1Christopher P Karch (Henry M. Jackson Foundation for the Advancement of Military Medicine)H-Index: 3
#1Christopher P. Karch (Henry M. Jackson Foundation for the Advancement of Military Medicine)H-Index: 1
Last. Gary R. Matyas (WRAIR: Walter Reed Army Institute of Research)H-Index: 31
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Introduction: An efficacious vaccine for HIV-1 has been sought for over 30 years to eliminate the virus from the human population. Many challenges have occurred in the attempt to produce a successf...
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#2Mangala Rao (WRAIR: Walter Reed Army Institute of Research)H-Index: 35
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A universal influenza candidate vaccine that targets multiple conserved influenza virus epitopes from hemagglutinin (HA), neuraminidase (NA) and matrix (M2e) proteins was combined with the potent Army liposomal adjuvant (ALFQ) to promote induction of broad immunity to seasonal and pandemic influenza strains. The unconjugated and CRM-conjugated composite peptides formulated with ALFQ were highly immunogenic and induced both humoral and cellular immune responses in mice. Broadly reactive serum ant...
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#1Wuertz Km (WRAIR: Walter Reed Army Institute of Research)H-Index: 1
#1Kathryn McGuckin Wuertz (WRAIR: Walter Reed Army Institute of Research)
Last. Akshaya Ganesh (WRAIR: Walter Reed Army Institute of Research)
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The emergence of SARS-CoV-2 variants of concern (VOC) requires adequate coverage of vaccine protection. We evaluated whether a spike ferritin nanoparticle vaccine (SpFN), adjuvanted with the Army Liposomal Formulation QS21 (ALFQ), conferred protection against the B.1.1.7 and B.1.351 VOCs in Syrian golden hamsters. SpFN-ALFQ was administered as either single or double-vaccination (0 and 4 week) regimens, using a high (10 μg) or low (0.2 μg) immunogen dose. Animals were intranasally challenged at ...
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#1Rodell C. Barrientos (WRAIR: Walter Reed Army Institute of Research)H-Index: 1
#1Rodell C. Barrientos (WRAIR: Walter Reed Army Institute of Research)H-Index: 6
Last. Gary R. Matyas (WRAIR: Walter Reed Army Institute of Research)H-Index: 31
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Opioid use disorders and fatal overdose due to consumption of fentanyl-laced heroin remain a major public health menace in the United States. Vaccination may serve as a promising potential remedy to combat accidental overdose and to mitigate the abuse potential of opioids. We previously reported the heroin and fentanyl monovalent vaccines carrying, respectively, a heroin hapten, 6-AmHap, and a fentanyl hapten, para-AmFenHap, conjugated to tetanus toxoid (TT). Herein, we describe the mixing of th...
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Opioid use disorder (OUD) is a serious health problem that has dramatically increased over the last decade. Although current therapies for the management of OUD can be effective, they have limitations. The complementary strategy to combat the opioid crisis is the development of a conjugate vaccine to generate high affinity antibodies in order to neutralize opioids in circulation before reaching the brain. The components of an opioid vaccine include an opioid hapten (6-AmHap) that is conjugated t...
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#1M. Gordon Joyce (WRAIR: Walter Reed Army Institute of Research)H-Index: 5
#2Wei-Hung Chen (WRAIR: Walter Reed Army Institute of Research)H-Index: 3
Last. Elaine B. Morrison (WRAIR: Walter Reed Army Institute of Research)H-Index: 2
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The need for SARS-CoV-2 next-generation vaccines has been highlighted by the rise of variants of concern (VoC) and the long-term threat of emerging coronaviruses. Here, we designed and characterized four categories of engineered nanoparticle immunogens that recapitulate the structural and antigenic properties of prefusion SARS-CoV-2 Spike (S), S1 and RBD. These immunogens induced robust S-binding, ACE2-inhibition, and authentic and pseudovirus neutralizing antibodies against SARS-CoV-2. A Spike-...
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#1Michael Gordon Joyce (WRAIR: Walter Reed Army Institute of Research)H-Index: 7
#1M.G. Joyce (WRAIR: Walter Reed Army Institute of Research)
Last. Kayvon Modjarrad (WRAIR: Walter Reed Army Institute of Research)H-Index: 30
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The need for SARS-CoV-2 next-generation vaccines has been highlighted by the rise of variants of concern (VoC) and the long-term threat of other coronaviruses. Here, we designed and characterized four categories of engineered nanoparticle immunogens that recapitulate the structural and antigenic properties of prefusion Spike (S), S1 and RBD. These immunogens induced robust S-binding, ACE2-inhibition, and authentic and pseudovirus neutralizing antibodies against SARS-CoV-2 in mice. A Spike-ferrit...
7 CitationsSource
#1Carmen Jm (WRAIR: Walter Reed Army Institute of Research)H-Index: 1
#1Joshua M. Carmen (WRAIR: Walter Reed Army Institute of Research)
Last. Mangala Rao (WRAIR: Walter Reed Army Institute of Research)H-Index: 35
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Potent cellular responses to viral infections are pivotal for long -lived protection. Evidence is growing that these responses are critical in SARS -CoV-2 immunity. Assessment of a SARS -CoV-2 spike ferritin nanoparticle (SpFN) immunogen paired with two distinct adjuvants, Alhydrogel(R) (AH) or Army Liposome Formulation containing QS-21 (ALFQ) demonstrated unique vaccine evoked immune signatures. SpFN+ALFQ enhanced recruitment of highly activated classical and non -classical antigen presenting c...
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#1Eugene S. Gutman (NIH: National Institutes of Health)H-Index: 1
Last. Rice K
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#1Eugene S. Gutman (NIH: National Institutes of Health)H-Index: 1
#2Thomas C. Irvin (NIH: National Institutes of Health)H-Index: 1
Last. Kenner C. Rice (NIH: National Institutes of Health)H-Index: 93
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Active immunization is being explored as a potential therapeutic to combat accidental overdose and to mitigate the abuse potential of opioids. Hapten design is one of the crucial factors that determines the efficacy of a candidate vaccine to substance abuse and remains one of the most active areas of research in vaccine development. Herein we report for the first time the synthesis of three novel opiate surrogates with the linker attachment site at C14, 1 (6,14-AmidoHap), 2 (14-AmidoMorHap), and...
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