Alison M. Dunning
University of Cambridge
GeneGenome-wide association studyCancerInternal medicineGenotypeSNPOncologyCase-control studySingle-nucleotide polymorphismOdds ratioAlleleGenetic associationProstate cancerPopulationBreast cancerGeneticsBioinformaticsGenetic predispositionMedicineBiology
Publications 485
#1Anna Morra (NKI-AVL: Netherlands Cancer Institute)H-Index: 1
#2Maria Escala-Garcia (NKI-AVL: Netherlands Cancer Institute)H-Index: 3
Last. Paul L. Auer (UWM: University of Wisconsin–Milwaukee)H-Index: 48
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BACKGROUND Given the high heterogeneity among breast tumors, associations between common germline genetic variants and survival that may exist within specific subgroups could go undetected in an unstratified set of breast cancer patients. METHODS We performed genome-wide association analyses within 15 subgroups of breast cancer patients based on prognostic factors, including hormone receptors, tumor grade, age, and type of systemic treatment. Analyses were based on 91,686 female patients of Euro...
#1Katherine S. Ruth (University of Exeter)H-Index: 26
#2Felix R. Day (University of Cambridge)H-Index: 40
Last. Jane L. Tarry-Adkins (University of Cambridge)H-Index: 22
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Reproductive longevity is essential for fertility and influences healthy ageing in women1,2, but insights into its underlying biological mechanisms and treatments to preserve it are limited. Here we identify 290 genetic determinants of ovarian ageing, assessed using normal variation in age at natural menopause (ANM) in about 200,000 women of European ancestry. These common alleles were associated with clinical extremes of ANM; women in the top 1% of genetic susceptibility have an equivalent risk...
3 CitationsSource
#1Hanla A Park (DKFZ: German Cancer Research Center)
#2Sonja Neumeyer (DKFZ: German Cancer Research Center)H-Index: 2
Last. Natalia AntonenkovaH-Index: 34
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Background null Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. null Methods null We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association stu...
#1Thomas U. Ahearn (Government of the United States of America)
Last. Francis Aitpillah (Komfo Anokye Teaching Hospital)H-Index: 8
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Background: Breast cancer risk estimates for women carrying germline mutations in breast cancer susceptibility genes are mainly based on studies of European ancestry women, with limited data for women in West African. Methods: We investigated associations between pathogenic variants in 34 putative susceptibility genes with breast cancer risk in 871 cases (307 estrogen receptor (ER)-positive, 321 ER-negative, and 243 ER-unknown) and 1,563 controls in a population-based study in Ghana, and estimat...
#1Charlotte SalmonH-Index: 1
Last. Janet L. Stanford (Fred Hutchinson Cancer Research Center)H-Index: 98
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#1Babatunde Adedokun (U of C: University of Chicago)H-Index: 15
#2Zhaohui Du (SC: University of Southern California)H-Index: 1
Last. Wei Zheng (Vandy: Vanderbilt University)H-Index: 170
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Our study describes breast cancer risk loci using a cross-ancestry GWAS approach. We first identify variants that are associated with breast cancer at P < 0.05 from African ancestry GWAS meta-analysis (9241 cases and 10193 controls), then meta-analyze with European ancestry GWAS data (122977 cases and 105974 controls) from the Breast Cancer Association Consortium. The approach identifies four loci for overall breast cancer risk [1p13.3, 5q31.1, 15q24 (two independent signals), and 15q26.3] and t...
#1Joseph S Baxter (ICR: Institute of Cancer Research)H-Index: 1
#2Nichola Johnson (ICR: Institute of Cancer Research)H-Index: 46
Last. Qin Wang (University of Cambridge)H-Index: 43
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A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. A recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 (signal 2), and 42 (signal 3) credible causal variants at these loci. We used publicly available in silico DNase I and ChIP-seq data with in vitro reporter gene and CRISPR assays to annotate signals 2 and 3. We identified putative regulatory elements that enhanced cell-type-specific trans...
1 CitationsSource
#1Joe Dennis (University of Cambridge)H-Index: 55
#2Tyrer Jp (University of Cambridge)H-Index: 2
Last. Doug Easton (University of Cambridge)H-Index: 62
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Background: Copy number variants (CNVs) are pervasive in the human genome but potential disease associations with rare CNVs have not been comprehensively assessed in large datasets. We analysed rare CNVs in genes and non-coding regions for 86,788 breast cancer cases and 76,122 controls of European ancestry with genome-wide array data. Results: Gene burden tests detected the strongest association for deletions in BRCA1 (P= 3.7E-18). Nine other genes were associated with a p-value < 0.01 including...
#1Xiaoliang WangH-Index: 6
Last. Sara LindströmH-Index: 60
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#1Juliette CoignardH-Index: 1
Last. Antonis C. Antoniou (University of Cambridge)H-Index: 83
view all 222 authors...