David E. Lanfear
Henry Ford Hospital
Internal medicineEndocrinologySurgeryCardiologyRetrospective cohort studyIntensive care medicineEmergency medicineHazard ratioNatriuretic peptideAsthmaHeart failureVentricular assist deviceDiseaseIn patientMyocardial infarctionProportional hazards modelPharmacogeneticsMedicineCohortEjection fraction
Publications 226
#1Jasmine A. Luzum (UM: University of Michigan)H-Index: 10
#2Ozioma Edokobi (UM: University of Michigan)
Last. David E. Lanfear (HFHS: Henry Ford Health System)H-Index: 31
view all 8 authors...
ABSTRACT null null Background null It remains unclear whether there is a racial disparity in the response to angiotensin inhibitors in patients with heart failure with reduced ejection fraction (HFrEF) and whether the role of genomic ancestry plays a part. Therefore, we compared survival rates associated with angiotensin inhibitors in patients with HFrEF by self-identified race and proportion of West African genomic ancestry. null null null Methods null Three datasets totaling 1153 and 1480 self...
#1Adam D. DeVore (Duke University)H-Index: 29
#2Bradi B. Granger (Duke University)H-Index: 23
Last. Clyde W. Yancy (NU: Northwestern University)H-Index: 121
view all 21 authors...
Importance null Adoption of guideline-directed medical therapy for patients with heart failure is variable. Interventions to improve guideline-directed medical therapy have failed to consistently achieve target metrics, and limited data exist to inform efforts to improve heart failure quality of care. null Objective null To evaluate the effect of a hospital and postdischarge quality improvement intervention compared with usual care on heart failure outcomes and care. null Design, setting, and pa...
1 CitationsSource
#1David E. Lanfear (HFH: Henry Ford Hospital)H-Index: 31
#2Jasmine A. Luzum (UM: University of Michigan)H-Index: 10
#1Hongsheng Gui (HFH: Henry Ford Hospital)H-Index: 18
#2Ruicong She (HFH: Henry Ford Hospital)H-Index: 3
Last. L. Keoki Williams (HFH: Henry Ford Hospital)H-Index: 53
view all 9 authors...
Background - It remains unclear whether the plasma proteome adds value to established predictors in heart failure (HF) with reduced ejection fraction (HFrEF). We sought to derive and validate a plasma proteomic risk score for survival in HFrEF patients (HFrEF-PRS). Methods - Patients meeting Framingham criteria for HF with EF<50% were enrolled (n=1017) and plasma underwent SOMAscan® profiling (4453 targets). Patients were randomly divided 2:1 into derivation and validation cohorts. The HFrEF-PRS...
#1Anthony Findley (WSU: Wayne State University)H-Index: 4
#2Monziani A (WSU: Wayne State University)H-Index: 1
Last. Francesca Luca (WSU: Wayne State University)H-Index: 23
view all 14 authors...
Genetic effects on gene expression and splicing can be modulated by cellular and environmental factors; yet interactions between genotypes, cell type and treatment have not been comprehensively studied together. We used an induced pluripotent stem cell system to study multiple cell types derived from the same individuals and exposed them to a large panel of treatments. Cellular responses involved different genes and pathways for gene expression and splicing, and were highly variable across conte...
4 CitationsSource
#1John A. Spertus (UMKC: University of Missouri–Kansas City)H-Index: 141
#2Mary Birmingham (Janssen Pharmaceutica)H-Index: 2
Last. John Whang (Janssen Pharmaceutica)
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Background The expense of clinical trials mandates new strategies to efficiently generate evidence and test novel therapies. In this context, we designed a decentralized, patient-centered randomized clinical trial leveraging mobile technologies, rather than in-person site visits, to test the efficacy of 12 weeks of canagliflozin for the treatment of heart failure, regardless of ejection fraction or diabetes status, on the reduction of heart failure symptoms. Methods One thousand nine hundred pat...
2 CitationsSource
#1Anuradha Lala (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 27
#2Keyur B. Shah (VCU: Virginia Commonwealth University)H-Index: 23
Last. Revival InvestigatorsH-Index: 4
view all 18 authors...
Abstract Objectives This study sought to determine cardiopulmonary exercise (CPX) predictors of the combined outcome of durable mechanical circulatory support (MCS), transplantation, or death at 1 year among patients with ambulatory advanced heart failure (HF). Background Optimal CPX predictors of outcomes in contemporary ambulatory advanced HF patients are unclear. Methods REVIVAL (Registry Evaluation of Vital Information for ventricular assist devices [VADs] in Ambulatory Life) enrolled 400 sy...
2 CitationsSource
#1Hongsheng Gui (HFHS: Henry Ford Health System)H-Index: 18
#2Albert M. Levin (HFHS: Henry Ford Health System)H-Index: 36
Last. L. Keoki Williams (HFHS: Henry Ford Health System)H-Index: 53
view all 30 authors...
Rationale: The 17q12-21.1 locus is one of the most highly replicated genetic associations with asthma. Individuals of African descent have lower LD in this region, which could facilitate identifyin...
4 CitationsSource
Abstract Background The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect ...
105 CitationsSource