Diana V. Pastrana
National Institutes of Health
SerotypeGeneGenotypeNeutralizationGenomePathologyMolecular biologyVirologyAntibodyPseudomonas exotoxinCapsidImmunologyVaccinationPlasmidVirusMerkel cell polyomavirusMerkel cell carcinomaImmunosuppressionHuman polyomavirus 6Polyomavirus InfectionsTiterRecombinant DNASerologyMonoclonal antibodyDNAMedicineBiologyImmune system
59Publications
30H-index
3,677Citations
Publications 56
Newest
3 CitationsSource
#1Samuel S. Porter (NIH: National Institutes of Health)H-Index: 2
#1Samuel S. Porter (UMD: University of Maryland, College Park)H-Index: 1
Last. Alison A. McBride (NIH: National Institutes of Health)H-Index: 50
view all 8 authors...
ABSTRACT An unusual feature of papillomaviruses is that their genomes are packaged into virions along with host histones. Viral minichromosomes were visualized as “beads on a string” by electron microscopy in the 1970s but, to date, little is known about the posttranslational modifications of these histones. To investigate this, we analyzed the histone modifications in HPV16/18 quasivirions, wart-derived bovine papillomavirus (BPV1), and wart-derived human papillomavirus type 1 (HPV1) using quan...
2 CitationsSource
#1Gabriel J. StarrettH-Index: 21
#2Michael J. TiszaH-Index: 7
Last. Christopher B. BuckH-Index: 52
view all 7 authors...
4 CitationsSource
#1Nicole L. WelchH-Index: 5
#2Michael J. TiszaH-Index: 7
Last. Christopher B. BuckH-Index: 52
view all 18 authors...
Abstract Adenoviruses, papillomaviruses, and polyomaviruses are collectively known as small DNA tumor viruses. Although it has long been recognized that small DNA tumor virus oncoproteins and capsid proteins show a variety of structural and functional similarities, it is unclear whether these similarities reflect descent from a common ancestor, convergent evolution, horizontal gene transfer among virus lineages, or acquisition of genes from host cells. Here, we report the discovery of a dozen ne...
6 CitationsSource
#1Gabriel J. StarrettH-Index: 21
#2Michael J. TiszaH-Index: 7
Last. Christopher B. BuckH-Index: 52
view all 7 authors...
Abstract Polintons (also known as Mavericks) were initially identified as a widespread class of eukaryotic transposons named for their hallmark type B DNA polymerase and retrovirus-like integrase genes. It has since been recognized that many polintons encode possible capsid proteins and viral genome-packaging ATPases similar to those of a diverse range of double-stranded DNA (dsDNA) viruses. This supports the inference that at least some polintons are viruses that remain capable of cell-to-cell ...
4 CitationsSource
#1Michael J. Tisza (NIH: National Institutes of Health)H-Index: 7
#2Diana V. Pastrana (NIH: National Institutes of Health)H-Index: 30
Last. Christopher B. Buck (NIH: National Institutes of Health)H-Index: 52
view all 26 authors...
When scientists hunt for new DNA sequences, sometimes they get a lot more than they bargained for. Such is the case in metagenomic surveys, which analyze not just DNA of a particular organism, but all the DNA in an environment at large. A vexing problem with these surveys is the overwhelming number of DNA sequences detected that are so different from any known microbe that they cannot be classified using traditional approaches. However, some of these “known unknowns” are undoubtedly viral sequen...
59 CitationsSource
#1Michael J. Tisza (NIH: National Institutes of Health)H-Index: 7
#2Diana V. Pastrana (NIH: National Institutes of Health)H-Index: 30
Last. Christopher B. Buck (NIH: National Institutes of Health)H-Index: 52
view all 26 authors...
7 CitationsSource
#1Nicole L. WelchH-Index: 5
#2Michael J. TiszaH-Index: 7
Last. Christopher B. BuckH-Index: 52
view all 18 authors...
Adenoviruses, papillomaviruses, parvoviruses and polyomaviruses are collectively known as small DNA tumor viruses. Although it has long been recognized that small DNA tumor virus oncoproteins and capsid proteins show a variety of structural and functional similarities, it is unclear whether these similarities reflect descent from a common ancestor, convergent evolution, horizontal gene transfer among virus lineages, or repeated acquisition of genes from host cells. We report the discovery of fou...
3 CitationsSource
#1Bahir H. Chamseddin (UTSW: University of Texas Southwestern Medical Center)H-Index: 5
#2Bao Anh Patrick D Tran (HU: Howard University)H-Index: 1
Last. Anna Yasmine Kirkorian (GW: George Washington University)H-Index: 2
view all 7 authors...
: A 6-year-old girl with a history of chronic immunosuppression following small bowel and colon transplantation for tufting enteropathy presented with a diffuse, facial-predominant eruption composed of pink-to-skin-colored papules with central white dystrophic spicules. Histology from a punch biopsy and polymerase chain reaction (PCR) from plucked spicules confirmed a diagnosis of trichodysplasia spinulosa (TS). Additional molecular studies identified several strains of the trichodysplasia spinu...
5 CitationsSource
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