Hajime Yoshifuji
Kyoto University
Internal medicinePathologyAntibodyDermatologyAutoantibodyHuman leukocyte antigenRheumatologyImmunologyVasculitisArthritisTocilizumabRheumatoid arthritisDermatomyositisDiseaseIgG4-related diseasePathogenesisIn patientTakayasu arteritisMedicineBiologyGastroenterology
Publications 127
#1Koji Kitagori (Kyoto University)H-Index: 8
#2Hajime Yoshifuji (Kyoto University)H-Index: 23
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 19 authors...
We assessed the utility of two forms of osteopontin (OPN), OPN full and its cleaved form (OPN N-half), in plasma and urine as markers of disease activity in lupus nephritis (LN). Samples were collected from patients with systemic lupus erythematosus (SLE) (LN: N = 29, non-LN: N = 27), IgA nephropathy (IgAN) (N = 14), minimal change nephrotic syndrome (MCNS) (N = 5), diabetic nephropathy (DN) (N = 14) and healthy volunteers (HC) (N = 17). While there was no significant difference in urine OPN ful...
12 CitationsSource
#1Chikashi TeraoH-Index: 32
#2Hajime Yoshifuji (Kyoto University)H-Index: 23
Last. Fumihiko MatsudaH-Index: 77
view all 12 authors...
To uncover the genetic background of relapsing polychondritis (RPC), a rare autoimmune disease with unknown mechanisms characterized by systemic inflammation of the cartilage, to deepen our understanding of the pathophysiology of RPC and show its distinct genetic characteristics from other rheumatic diseases.A total of 102 patients with RPC and 1000 healthy subjects were recruited for a two-staged genetic association study and genotyped for six HLA classical loci. Haplotype association tests wer...
13 CitationsSource
#1Hideaki Tsuji (Kyoto University)H-Index: 8
#2Koichiro Ohmura (Kyoto University)H-Index: 35
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 9 authors...
Objective It is well known that grapefruit juice (GFJ) elevates the blood tacrolimus (TAC) concentration. We investigated the efficacy and safety of GFJ intake with TAC in cases of connective tissue diseases in which the TAC blood concentration was insufficiently high for clinical improvement, even when 3 mg/day or more of TAC was administered. Methods Seven patients took 200 mL of GFJ every day. The trough levels of the TAC blood concentration were measured before and after GFJ intake and the c...
2 CitationsSource
#1Toshiki Nakajima (Kyoto University)H-Index: 8
#2Hajime Yoshifuji (Kyoto University)H-Index: 23
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 10 authors...
Background We preliminarily found a SNP (rs6871626, A vs. C) in IL-12B region as a susceptibility gene to Takayasu arteritis (TAK) by genome-wide association study. IL-12B encodes IL-12p40 that is a component of both IL-12p70 and IL-23. The significance of IL-12p40 in pathophysiology of TAK has not been fully investigated yet. Moreover, there has been no consistent evidence about whether IL-12p70 or IL-23 is important in TAK. Objectives 1) To investigate the expression of IL-12p40 in patients wi...
#1Chikashi Terao (Kyoto University)H-Index: 32
#2Hajime Yoshifuji (Kyoto University)H-Index: 23
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 6 authors...
Takayasu arteritis (TAK) is a systemic vasculitis affecting the large arteries (1). Glucocorticoids and immunosuppressants including biological agents targeting tumour necrosis factor (TNF)-α and t...
38 CitationsSource
#1Noriyuki Yamakawa (Kyoto University)H-Index: 9
#2Kengo Oe (Kyoto University)H-Index: 1
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 13 authors...
: Hereditary hemochromatosis (HH) is an inherited disorder usually seen in Northern Europeans, which results in iron overload syndrome. A few cases have also been reported in Japan. We herein report a Japanese man presenting with fever, arthritis, liver dysfunction, and hyperferritinemia who was diagnosed with type 4 HH. He was heterozygous for the 1520A>G (His507Arg) mutation in the ferroportin-1 gene (SLC40A1). He had a familial cataract as an infant, but hereditary hyperferritinemia cataract ...
7 CitationsSource
#1Sumie HiramatsuH-Index: 1
#2Koichiro OhmuraH-Index: 35
Last. Tsuneyo MimoriH-Index: 77
view all 14 authors...
TAFRO syndrome is a newly defined disease entity which is characterized by thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly. A histological pattern of multiple lymphadenopathy of atypical Castleman's disease (CD) is also an important characteristic. A 48-year-old man was referred to our hospital with fever, asthenia, bilateral pleural effusion, ascites, generalized edema, dyspnea, hypoalbuminemia, severe thrombocytopenia, anemia, renal failure and proteinuria, where...
22 CitationsSource
#1Miyuki Kono (Hitachi)H-Index: 2
#2Naoto Miura (Hitachi)H-Index: 7
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 12 authors...
Objective To examine how connective tissue diseases affect finger-vein pattern authentication.
2 CitationsSource
#1Atsushi Ogata (Osaka University)H-Index: 53
#2Tatsuya Atsumi (Hokkaido University)H-Index: 65
Last. Akira NomuraH-Index: 4
view all 22 authors...
Objective To evaluate the efficacy and safety of switching from intravenous (IV) tocilizumab (TCZ) to subcutaneous (SC) TCZ monotherapy in rheumatoid arthritis patients. Methods Patients who had completed 24 weeks of TCZ-SC (162 mg/2 weeks) or TCZ-IV (8 mg/kg/4 weeks) monotherapy in the double-blind period of the MUSASHI study were enrolled in an 84-week open-label extension period. All received TCZ-SC (162 mg/2 weeks) monotherapy. Effects of the IV to SC switch were evaluated at week 36 (12 wee...
20 CitationsSource
Background Anti-cyclic citrullinated peptide antibody (aCCP) is a widely-used diagnostic marker for rheumatoid arthritis (RA). In spite of its very high specificity, it is also reported that 5 to 10% of non-RA connective tissue disease (CTD) patients are positive for aCCP [1]. It is unknown whether such aCCP-positive non-RA CTD patients may develop RA later. There are few reports that referred long term outcome of aCCP-positive CTD patients. Objectives To investigate whether aCCP-positive non-RA...