Hajime Yoshifuji
Kyoto University
Internal medicinePathologyAntibodyDermatologyAutoantibodyHuman leukocyte antigenRheumatologyImmunologyVasculitisArthritisTocilizumabRheumatoid arthritisDermatomyositisDiseaseIgG4-related diseasePathogenesisIn patientTakayasu arteritisMedicineBiologyGastroenterology
128Publications
23H-index
2,077Citations
Publications 127
Newest
#1Nozomi IshigookaH-Index: 3
#2Takuma FujiiH-Index: 21
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 13 authors...
BackgroundMutated citrullinated vimentin (MCV) is one of the important targets of anti-citrullinated protein/peptide antibodies (ACPA) and is found in synovial fluid in patients with rheumatoid arthritis (RA). Serum anti-MCV antibody (anti-MCV) titer may be better correlated with RA disease activity
1 CitationsSource
#1Kosaku MurakamiH-Index: 14
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 13 authors...
Background Previously it has been described that lipid and lipid mediators are present in synovial fluid from patients with rheumatoid arthritis (RA). It is, however, currently unknown to what extent these lipid mediators are involved in disease pathophysiology. Objectives The aim of this study is to clarify which lipid mediators in plasma correlate with disease activity of RA. Methods We obtained blood from RA patients registered in the KURAMA (Kyoto University Rheumatoid Arthritis Management A...
Source
#1Chikashi Terao (Kyoto University)H-Index: 32
#2Takahisa Kawaguchi (Kyoto University)H-Index: 28
Last. Yannick Allanore (Paris V: Paris Descartes University)H-Index: 81
view all 54 authors...
Objectives Systemic sclerosis (SSc) is an autoimmune disease characterised by skin and systemic fibrosis culminating in organ damage. Previous genetic studies including genome-wide association studies (GWAS) have identified 12 susceptibility loci satisfying genome-wide significance. Transethnic meta-analyses have successfully expanded the list of susceptibility genes and deepened biological insights for other autoimmune diseases. Methods We performed transethnic meta-analysis of GWAS in the Japa...
35 CitationsSource
#1Adeeb Salah (Kyoto University)H-Index: 4
#2Hajime Yoshifuji (Kyoto University)H-Index: 23
Last. Aya Miyagawa-Hayashino (Kyoto University)H-Index: 22
view all 10 authors...
Objectives. Immunoglobulin G4-related disease (IgG4-RD) is a multiorgan condition manifesting itself in different forms. This study aimed to investigate protein expression profiles and to find the possible biomarker for IgG4-RD by liquid chromatography mass spectrometry (LC-MS) using tissue sections in IgG4-RD patients. Methods. Protein expression profiles in five IgG4-related pancreatitis and three normal pancreatic samples were compared using LC-MS and were validated by quantitative real-time ...
9 CitationsSource
#1Takahiko SugiharaH-Index: 15
#2Hitoshi Hasegawa (Ehime University)H-Index: 35
Last. Mitsuaki Isobe (Tokyo Medical and Dental University)H-Index: 69
view all 11 authors...
Source
#1Toshiki Nakajima (Kyoto University)H-Index: 8
#2Hajime Yoshifuji (Kyoto University)H-Index: 23
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 9 authors...
Source
#1Yuji Hosono (Kyoto University)H-Index: 16
#2Ran Nakashima (Kyoto University)H-Index: 21
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 9 authors...
Abstract Objective Anti-MDA5 antibody positive dermatomyositis (DM) and clinically amyopathic DM (CADM) often develop into rapidly progressive interstitial lung disease, but their pathogenesis remains unclear. We observed that sera from DM/CADM patients immunoprecipitated a common 110 kDa polypeptide. We investigated this autoantigen and its clinical significance. Methods Autoantibodies were screened in 333 patients with various connective tissue diseases (CTDs) and 20 healthy controls (HCs) by ...
9 CitationsSource
#1Masato MoriH-Index: 3
#2Motomu HashimotoH-Index: 21
Last. Tsuneyo MimoriH-Index: 77
view all 16 authors...
AbstractObjective: To determine how cell–cell contact with synovial fibroblasts (SF) influence on the proliferation and cytokine production of CD4+ T cells.Methods: Naive CD4+ T cells were cultured with SF from rheumatoid arthritis patients, stimulated by anti-CD3/28 antibody, and CD4+ T cell proliferation and IFN-γ/IL-17 production were analyzed. To study the role of adhesion molecules, cell contact was blocked by transwell plate or anti-intracellular adhesion molecule-1 (ICAM-1)/vascular cell ...
11 CitationsSource
: In systemic lupus erythematosus (SLE), lupus nephritis (LN) is an important complication as an intractable condition and considered to be a prognostic factor. Based on the past reports that explain immunological functions of OPN and its relationship with autoimmune diseases such as LN or IgA nephropathy, we measured OPN full and OPN N-half in serum and urine of SLE patients and examined the possibility as a disease biomarker. OPN N-half is known as a more physiologically active form than OPN f...
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#1Hideaki Tsuji (Kyoto University)H-Index: 8
#2Hajime Yoshifuji (Kyoto University)H-Index: 23
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 10 authors...
We report on a 30-year-old Japanese woman with granulomatosis with polyangiitis (GPA) complicated by pituitary diabetes insipidus and multiple lung granulomas. The granulomas disappeared with prednisolone (50 mg/day) and rituximab, although continuous nasal desmopressin was needed to control diabetes insipidus after immunosuppressive therapies. At the time of presentation, the patient had abdominal pain and disseminated intravascular coagulation but no rash. She died of continuous hemorrhage fro...
12 CitationsSource