Hajime Yoshifuji
Kyoto University
Internal medicinePathologyAntibodyDermatologyAutoantibodyHuman leukocyte antigenRheumatologyImmunologyVasculitisArthritisTocilizumabRheumatoid arthritisDermatomyositisDiseaseIgG4-related diseasePathogenesisIn patientTakayasu arteritisMedicineBiologyGastroenterology
Publications 127
#1Hajime Yoshifuji (Kyoto University)H-Index: 23
#2Sumika Kagebayashi (Kyoto University)
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 7 authors...
Pulmonary arterial hypertension (PAH) is a rare complication of ANCA-associated vasculitis (AAV). We report a 37-year-old man with PAH complicated by both AAV and SSc who presented with dyspnea, ca...
#1Takafumi Niwamoto (Kyoto University)H-Index: 1
#2Tomohiro Handa (Kyoto University)H-Index: 27
Last. Toyohiro Hirai (Kyoto University)H-Index: 37
view all 12 authors...
AbstractObjectives: Immunoglobulin G4-related disease (IgG4-RD) is a systemic, multiorgan disease of unknown etiology. We aimed to classify IgG4-RD by a combination pattern of affected organs and i...
4 CitationsSource
#1Hideaki Tsuji (Kyoto University)H-Index: 8
#2Hajime Yoshifuji (Kyoto University)H-Index: 23
Last. Koichiro Ohmura (Kyoto University)H-Index: 35
view all 13 authors...
We report a case of 68-year-old man with stable polymyositis complicated with primary hepatic lymphoma (PHL) as other iatrogenic immunodeficiency-related lymphoproliferative disorders (OIIA-LPD). Multiple liver masses were diagnosed as diffuse large B-cell lymphoma (DLBCL) by biopsy. The LPD was associated with Epstein-Barr virus (EBV) reactivation, because EBV-DNA was detected in peripheral blood, and EBV antigen was detected in the tumour. He presented with high fever, cytopenia and hyperferri...
#1Mirei ShirakashiH-Index: 4
#2Ran NakashimaH-Index: 21
Last. Tsuneyo MimoriH-Index: 77
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OBJECTIVES: Rapidly progressive interstitial lung disease (RP-ILD) with poor prognosis often accompanies anti-melanoma differentiation-associated gene 5 (MDA5)-positive DM. Combined immunosuppressive therapy, including glucocorticoids, calcineurin inhibitors and intravenous cyclophosphamide (IVCY) is reportedly effective in DM with RP-ILD, but some patients remain resistant to therapy. We examined the utility of plasma exchange (PE) in such intractable cases and investigated the prognostic facto...
6 CitationsSource
#1Takeshi Iwasaki (Kyoto University)H-Index: 1
#2Shuichiro Nakabo (Kyoto University)H-Index: 10
Last. Koichiro Ohmura (Kyoto University)H-Index: 35
view all 17 authors...
BACKGROUND The anti-cyclic citrullinated peptide (CCP) antibody is a diagnostic biomarker of rheumatoid arthritis (RA). However, some non-RA connective tissue disease (CTD) patients also test positive for the anti-CCP antibody and, thus, may ultimately develop RA. We retrospectively investigated whether anti-CCP-positive non-RA CTD patients developed RA and attempted to identify factors that may differentiate RA-overlapping CTD from pure CTD. METHODS In total, 842 CTD patients with a primary dia...
#1S. Kondo-Ishikawa (Kyoto University)H-Index: 2
#2Takao Fujii (Kyoto University)H-Index: 32
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 10 authors...
BackgroundAutoantibodies (auto Abs) and inflammatory mediators (IMs) in cerebrospinal fluid (CSF) may be involved in the pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE). It is...
1 CitationsSource
#1Yoshikazu Nakaoka (Osaka University)H-Index: 24
#2Mitsuaki IsobeH-Index: 69
Last. Norihiro Nishimoto (TMU: Tokyo Medical University)H-Index: 69
view all 25 authors...
OBJECTIVE: To investigate the long-term efficacy and safety of the IL-6 receptor antibody tocilizumab in patients with Takayasu arteritis (TAK). METHODS: Patients completing the randomized, double-blind, placebo-controlled period of the TAKT (Takayasu arteritis Treated with Tocilizumab) trial were followed up during open-label extended treatment with weekly s.c. tocilizumab 162 mg for up to 96 weeks or longer, with oral glucocorticoid tapering performed at the investigators' discretion. Endpoint...
14 CitationsSource
#1Yohei Korogi (Kyoto University)H-Index: 9
#2Nozomi Tanaka (Kyoto University)H-Index: 2
Last. Kiminobu Tanizawa (Kyoto University)H-Index: 21
view all 6 authors...
When a patient with Behcet disease presents with haemoptysis, pulmonary vascular involvement should be considered.
1 CitationsSource
#1Hajime Yoshifuji (Kyoto University)H-Index: 23
#2Chikashi Terao (University of Shizuoka)H-Index: 8
Takayasu arteritis (TAK) affects the aorta and its primary branches, mainly in young women. In its advanced stages, it can cause severe complications, such as cerebral infarction, impaired vision, and valvular heart diseases. In the aortic tissue of TAK, there is increased infiltration of cytotoxic lymphocytes, such as natural killer (NK) cells and CD8+T cells, and enhanced expression of accessory molecules, such as major histocompatibility complex (MHC) and MHC class I chain-related gene (MIC) ...
3 CitationsSource
#1Yuya Tabuchi (Kyoto University)H-Index: 2
#2Motomu Hashimoto (Kyoto University)H-Index: 21
Last. Koichiro Ohmura (Kyoto University)H-Index: 35
view all 8 authors...
Background: SKG mice have been known for their autoreactive Th17 cells resulting from the insufficient thymic negative selection due to a Zap70 mutation1,2). Under specific pathogen-free conditions, they acquire features of spondyloarthritis (SpA) by intraperitoneal injection of curdlan, a (1,3)-β-glucan3). Several reports have shown that Th17 cells also increase in human SpA4). However, CTLA4-Ig, which ameliorates rheumatoid arthritis by suppressing pathogenic cells such as effector T cells, wa...