Hajime Yoshifuji
Kyoto University
Internal medicinePathologyAntibodyDermatologyAutoantibodyHuman leukocyte antigenRheumatologyImmunologyVasculitisArthritisTocilizumabRheumatoid arthritisDermatomyositisDiseaseIgG4-related diseasePathogenesisIn patientTakayasu arteritisMedicineBiologyGastroenterology
128Publications
23H-index
2,077Citations
Publications 127
Newest
#1Naoki YamamotoH-Index: 23
#2Hiroshi Yamaguchi (Kyoto University)H-Index: 3
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 11 authors...
ObjectiveImpaired clearance of apoptotic cells is a potential trigger of systemic lupus erythematosus (SLE). Milk fat globule epidermal growth factor 8 (MFG-E8) plays an important role in the clearance of dying cells. Previously, we reported serum MFG-E8 was elevated in some SLE patients. Here we further investigated the prevalence of MFG-E8 in active SLE and other autoimmune diseases and also tried to clarify the characteristics of MFG-E8-positive and -negative SLE.MethodsSerum MFG-E8 was measu...
13 CitationsSource
#1Tomoko Yokoyama (Kyoto University)H-Index: 4
#2Takao Fujii (Kyoto University)H-Index: 32
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 9 authors...
ObjectiveWe investigated possible associations between neurotoxic inflammatory mediators (IMs) and anti-U1RNP antibodies (Abs) in cerebrospinal fluid (CSF) of neuropsychiatric systemic lupus erythematosus (NPSLE).MethodsSerum and CSF anti-U1RNP Abs were detected using an RNA-immunoprecipitation assay and CSF anti-U1RNP Ab levels were measured by ELISA. IFN-α, MCP-1 and IL-8 levels in CSF were determined by quantitative multiplex cytokine analysis. IM levels were compared among anti-U1RNP-positiv...
11 CitationsSource
#1Kosuke Tanaka (Kyoto University)H-Index: 1
#2Chikashi Terao (Kyoto University)H-Index: 32
Last. Fumihiko MatsudaH-Index: 77
view all 12 authors...
Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases
5 CitationsSource
#1Noriyuki YamakawaH-Index: 9
#2Masakazu FujimotoH-Index: 14
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 21 authors...
Objective. Methotrexate-associated lymphoproliferative disorders (MTX-LPD) often regress spontaneously during MTX withdrawal, but the prognostic factors remain unclear. The aim of our study was to clarify the clinical, histological, and genetic factors that predict outcomes in patients with MTX-LPD. Methods. Patients with MTX-LPD diagnosed between 2000 and 2012 were analyzed retrospectively regarding their clinical course, site of biopsy, histological typing, Epstein-Barr virus (EBV) in situ hyb...
62 CitationsSource
#1Chikashi Terao (Kyoto University)H-Index: 32
#2Motomu Hashimoto (Kyoto University)H-Index: 21
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 13 authors...
Rheumatoid arthritis (RA) is a bone destructive autoimmune disease. Many patients with RA recognize fluctuations of their joint synovitis according to changes of air pressure, but the correlations between them have never been addressed in large-scale association studies. To address this point we recruited large-scale assessments of RA activity in a Japanese population, and performed an association analysis. Here, a total of 23,064 assessments of RA activity from 2,131 patients were obtained from...
10 CitationsSource
The prognosis of connective tissue disease (CTD)-associated pulmonary arterial hypertension (PAH) is so poor that early therapeutic intervention is advisable. Borderline PAH (21-24 mmHg mean pulmonary arterial pressure) is a concept created to distinguish cases that would become definite PAH. It is controversial whether borderline PAH cases with no symptoms should be treated, but therapeutic intervention in the case of borderline PAH is justified when systemic sclerosis (SSc) is in the backgroun...
Source
#1Chikashi Terao (Kyoto University)H-Index: 32
#2Hajime Yoshifuji (Kyoto University)H-Index: 23
Last. Fumihiko MatsudaH-Index: 77
view all 4 authors...
: Takayasu arteritis (TAK) is a systemic vasculitis affecting aorta and its large branches which were firstly reported from Japan. TAK develops mainly in young females and the number of patients with TAK in Japan is estimated about 6,000 to 10,000. This low prevalence has made genetic studies of TAK difficult to elucidate its genetic background. The HLA region, especially HLA-B locus, is the strongest susceptibility locus to TAK. The association between TAK and HLA-B*52:01 has been established b...
Source
#1Toshiki Nakajima (Kyoto University)H-Index: 8
#2Daisuke Kawabata (Kyoto University)H-Index: 21
Last. Tsuneyo Mimori (Kyoto University)H-Index: 77
view all 9 authors...
: A 75-year-old woman with rheumatoid arthritis (RA) presented with long-term painful erythema on the right upper arm and left elbow. The patient was diagnosed with intralymphatic histiocytosis (ILH) based on the biopsy findings. Because the patient was unresponsive to single-agent treatment with methotrexate, infliximab and etanercept, we switched to tocilizumab (TCZ) treatment, which induced remission of the ILH. Our case suggests that TCZ may be a treatment option for ILH in patients with RA.
9 CitationsSource
#1Masaki KatayamaH-Index: 11
#2Koichiro OhmuraH-Index: 35
Last. Tsuneyo MimoriH-Index: 77
view all 10 authors...
An error was introduced in the preparation of this article for publication. Figure 2, “Histopathology of ankle joints from arthritic IL-17KO and WT mice,” is incorrect. Please view Figure 2 here:
3 CitationsSource
#1Ryosuke HiwaH-Index: 5
#2Koichiro OhmuraH-Index: 35
Last. Tsuneyo MimoriH-Index: 77
view all 13 authors...