Hajime Yoshifuji
Kyoto University
Internal medicinePathologyAntibodyDermatologyAutoantibodyHuman leukocyte antigenRheumatologyImmunologyVasculitisArthritisTocilizumabRheumatoid arthritisDermatomyositisDiseaseIgG4-related diseasePathogenesisIn patientTakayasu arteritisMedicineBiologyGastroenterology
Publications 127
#1Atsushi Shima (Kyoto University)H-Index: 2
#2Takakuni Maki (Kyoto University)H-Index: 25
Last. Ryosuke Takahashi (Kyoto University)H-Index: 80
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Abstract null null The pathomechanisms and treatment strategy for rare presentations of reversible cerebral vasoconstriction syndrome (RCVS) with anti-phospholipid syndrome (APS) remain to be determined. We report a 67-year-old woman with APS who presented with ischemic stroke due to RCVS. She was treated with low-dose cilostazol and lomerizine hydrochloride, which resulted in functional improvement and recovery of vasoconstriction within 12 weeks. Her plasma endothelin-1 level was decreased aft...
#1Keiichiro Kadoba (Kyoto University)H-Index: 1
#2Ryu Watanabe (Kyoto University)H-Index: 19
Last. Masao Tanaka (Kyoto University)H-Index: 23
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HLA-B*52 is an established genetic factor in Takayasu arteritis (TAK). Recently, single nucleotide polymorphisms (SNPs) in IL12B (rs6871626) and LILRA3 (rs103294) were newly identified as non-HLA susceptibility loci in TAK. Here, we examined how these SNPs contribute to clinical characteristics and vascular damage in TAK. We retrospectively reviewed the medical records of 99 TAK patients enrolled in our previous genome-wide association study, and whose genotypes for IL12B rs6871626, LILRA3 rs103...
#1Yudai Takase (Kyoto University)H-Index: 1
#2Takeshi Iwasaki (Kyoto University)H-Index: 1
Last. Yuya Tabuchi (Kyoto University)H-Index: 2
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OBJECTIVES It is important to clarify the relationship between irreversible organ damage and the quality of life (QOL) by considering the unique factors of patients with systemic lupus erythematosus (SLE). We aimed to clarify their correlation using SLE-specific QOL assessment tools. We also aimed to identify which type of organ damage is adversely correlated with the QOL. METHODS We conducted a questionnaire-based survey of outpatients with SLE at Kyoto University Hospital and evaluated irrever...
#1Mineto Ota (UTokyo: University of Tokyo)H-Index: 4
#2Yasuo Nagafuchi (UTokyo: University of Tokyo)H-Index: 11
Last. Keishi Fujio (UTokyo: University of Tokyo)H-Index: 29
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Summary Genetic studies have revealed many variant loci that are associated with immune-mediated diseases. To elucidate the disease pathogenesis, it is essential to understand the function of these variants, especially under disease-associated conditions. Here, we performed a large-scale immune cell gene-expression analysis, together with whole-genome sequence analysis. Our dataset consists of 28 distinct immune cell subsets from 337 patients diagnosed with 10 categories of immune-mediated disea...
#1Yoshie Gon (Kyoto University)H-Index: 2
#2Hajime Yoshifuji (Kyoto University)H-Index: 23
Last. Chikashi Terao (Kyoto University)H-Index: 32
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Objectives: Biologics have been used to treat refractory Takayasu arteritis (TAK), but their efficacy and safety have not been sufficiently evaluated.Methods: We extracted clinical information from...
3 CitationsSource
#1Hiroshi Doi (Kyoto University)H-Index: 4
#2Koichiro Ohmura (Kyoto University)H-Index: 35
Last. Morinobu Akio (Kyoto University)
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ObjectiveThe systemic lupus erythematosus (SLE) symptom checklist (SSC) is a patient-reported outcome measure consisting of 38 queries. We translated SSC into Japanese and attempted to validate its...
#1Keiichiro Kadoba (Kyoto University)H-Index: 1
#2Ryu Watanabe (Kyoto University)H-Index: 19
Last. Hajime Yoshifuji (Kyoto University)H-Index: 23
view all 6 authors...
#1Emily Rose (NIH: National Institutes of Health)H-Index: 1
#2Marcela A. Ferrada (NIH: National Institutes of Health)H-Index: 5
Last. Peter C. Grayson (NIH: National Institutes of Health)H-Index: 25
view all 12 authors...
OBJECTIVE Relapsing polychondritis (RP) is a systemic inflammatory disorder of cartilage that lacks validated disease activity measures. Physician global assessment (PhGA), a measure of disease activity commonly used in rheumatologic diseases, has not been tested in a cohort of patients with RP. METHODS Adult patients in an observational cohort of RP underwent standardized, comprehensive evaluation at approximately 6-month intervals. PhGA was scored by three physicians from the evaluating instit...