Hajime Hosoi
Kyoto Prefectural University of Medicine
Internal medicineEndocrinologySurgeryPathologyOncologyMolecular biologyChemistryApoptosisImmunologyChemotherapyNeuroblastomaRhabdomyosarcomaTransplantationCell cycleCancer researchCell growthMedicineCell cultureBiologyGastroenterology
Publications 229
#1Satoshi Sakaue (Kyoto Prefectural University of Medicine)H-Index: 2
#2Takashi Kasai (Kyoto Prefectural University of Medicine)H-Index: 18
Last. Toshiki Mizuno (Kyoto Prefectural University of Medicine)H-Index: 30
view all 14 authors...
Phosphoglycerate kinase 1 (PGK-1) is a glycolytic enzyme encoded by PGK-1, which maps to the X chromosome. PGK-1 deficiency causes X-linked recessive hereditary chronic hemolytic anemia, myopathy, and neurological disorders due to insufficient ATP regeneration. Early-onset parkinsonism has occasionally been reported as a neurological complication of this condition. However, heterozygous carriers of PGK-1 deficiency were thought to be neurologically asymptomatic. Here, we report a boy with PGK-1 ...
13 CitationsSource
#1Kazuki Kodo (Kyoto Prefectural University of Medicine)H-Index: 4
#2Satoru Sugimoto (Kyoto Prefectural University of Medicine)H-Index: 4
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 10 authors...
Erythropoietin (EPO), clinically used as a hematopoietic drug, has received much attention due to its nonhematopoietic effects. EPO reportedly has beneficial effects on obesity and diabetes mellitus. We investigated whether interscapular brown adipose tissue (iBAT: main part of classical BAT) could play a role in EPO’s anti-obesity and anti-diabetic effects in diet-induced obese mice. Four-week-old male C57BL/6J mice were fed a high-fat diet (HFD-Con), and half were additionally given an intrape...
16 CitationsSource
#1Kenichi Sakamoto (Kyoto Prefectural University of Medicine)H-Index: 7
#2Chihiro Tomoyasu (Kyoto Prefectural University of Medicine)H-Index: 3
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 13 authors...
HLA-Flow is a flow cytometry-based method using anti-HLA antibodies against mismatched HLA alleles combined with the antibodies against antigens expressed on leukemic cells. It is a sensitive assay to determine minimal residual disease (MRD) after HLA mismatched hematopoietic stem cell transplantation (HSCT). In this study, we report the results of our HLA-Flow using six-color based multicolor fluorescence-activated cell sorting for HLA-mismatched HSCT. We performed HLA-Flow monitoring after HLA...
#1Satoshi Kidowaki (Kyoto Prefectural University of Medicine)H-Index: 5
#2Masafumi Morimoto (Kyoto Prefectural University of Medicine)H-Index: 21
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 12 authors...
Abstract Purpose We used diffusion tensor imaging (DTI) to evaluate longitudinal changes in fractional anisotropy (FA) of white matter tracts in preterm infants without abnormal magnetic resonance imaging (MRI) findings. Imaging was conducted at term equivalent age (TEA) and 1 year of corrected age. Furthermore, we assessed correlations between FA and neurodevelopmental outcomes at 3 years of corrected age to investigate brain prematurity of preterm infants without MRI abnormalities. Methods Pre...
6 CitationsSource
#1Tomoya Isobe (UTokyo: University of Tokyo)H-Index: 6
#2Masafumi Seki (UTokyo: University of Tokyo)H-Index: 10
Last. Junko Takita (UTokyo: University of Tokyo)H-Index: 32
view all 37 authors...
Pancreatoblastoma is a rare pediatric pancreatic malignancy for which the molecular pathogenesis is not understood. In this study, we report the findings of an integrated multiomics study of whole-exome and RNA sequencing as well as genome-wide copy number and methylation analyses of ten pancreatoblastoma cases. The pancreatoblastoma genome was characterized by a high frequency of aberrant activation of the Wnt signaling pathway, either via somatic mutations of CTNNB1 (90%) and copy-neutral loss...
6 CitationsSource
#1Osamu Otabe (Kyoto Prefectural University of Medicine)H-Index: 6
#2Ken Kikuchi (Kyoto Prefectural University of Medicine)H-Index: 14
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 8 authors...
Abstract In alveolar rhabdomyosarcoma (ARMS) that is a highly malignant pediatric soft tissue tumor, MET, a receptor of hepatocyte growth factor (HGF), was reported to be downstream of the PAX3-FOXO1 fusion gene specific to ARMS, and a key mediator of metastatic behavior in RMS. So far, no studies have investigated the downstream signaling pathways of MET in ARMS, even though HGF and MET have been suggested to be deeply involved in the invasiveness of ARMS. In this study, we demonstrated the fun...
5 CitationsSource
#1Tomoko Tanaka (Kyoto Prefectural University of Medicine)H-Index: 4
#2Mayumi Higashi (Kyoto Prefectural University of Medicine)H-Index: 9
Last. Tatsuro Tajiri (Kyoto Prefectural University of Medicine)H-Index: 20
view all 9 authors...
Abstract Background A recent study reported that relapsed neuroblastomas had frequent RAS–ERK pathway mutations. We herein investigated the effects and pathways of MEK inhibitors, which inhibit the RAS–ERK pathway, as a new molecular-targeted therapy for refractory neuroblastomas. Method Five neuroblastoma cell lines were treated with trametinib (MEK inhibitor) or CH5126766 (RAF/MEK inhibitor). Growth inhibition was analyzed using a cell viability assay. ERK phosphorylation and the MYCN expressi...
18 CitationsSource
Inflammatory myofibroblastic tumor (IMT), which expresses cyclooxygenase-2 (COX-2), can be effectively treated with COX-2 inhibitor. Here, we report a case of urinary bladder IMT in a 13-year-old boy. Although total cystectomy was initially planned for complete resection of the tumor, neoadjuvant treatment with COX-2 inhibitor and prednisolone reduced the size of the tumor and enabled complete resection of the tumor by partial cystectomy. Neoadjuvant treatment with COX-2 inhibitor and prednisolo...
2 CitationsSource
#1Seishiro Nodomi (Kyoto University)H-Index: 6
#2Katsutsugu Umeda (Kyoto University)H-Index: 15
Last. Toshio Heike (Kyoto University)H-Index: 58
view all 16 authors...
Malignant rhabdoid tumor (MRT) is a rare, highly aggressive pediatric malignancy that primarily develops during infancy and early childhood. Despite the existing standard of intensive multimodal therapy, the prognosis of patients with MRT is dismal; therefore, a greater understanding of the biology of this disease is required to establish novel therapies. In this study, we identified a highly tumorigenic sub-population in MRT, based on the expression of CD146 (also known as melanoma cell adhesio...
9 CitationsSource