Hajime Hosoi
Kyoto Prefectural University of Medicine
Internal medicineEndocrinologySurgeryPathologyOncologyMolecular biologyChemistryApoptosisImmunologyChemotherapyNeuroblastomaRhabdomyosarcomaTransplantationCell cycleCancer researchCell growthMedicineCell cultureBiologyGastroenterology
230Publications
33H-index
4,497Citations
Publications 229
Newest
#1Yuko Sanada (UTokyo: University of Tokyo)H-Index: 1
#2Miyuki Harada (UTokyo: University of Tokyo)H-Index: 28
Last. Yutaka Osuga (UTokyo: University of Tokyo)H-Index: 62
view all 18 authors...
Aim: The survival rates of cancer patients have greatly improved owing to the advances in oncology. The preservation of fertility in cancer patients is an important task. To determine the reality of cryopreservation of embryos, oocytes and ovarian tissue in cancer patients, large-scale survey analysis was performed in Japan. Methods: We sent 613 Japan Society of Obstetrics and Gynecology-certified assisted reproductive technology institutions a questionnaire about their experience of performing ...
4 CitationsSource
#1Naohiro Okano (Kyorin University)H-Index: 9
#2Makoto UenoH-Index: 3
Last. J. Furuse (Kyorin University)H-Index: 11
view all 17 authors...
3 CitationsSource
#1Tomoko Iehara (Kyoto Prefectural University of Medicine)H-Index: 21
#2Shigeki Yagyu (Kyoto Prefectural University of Medicine)H-Index: 14
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 9 authors...
BACKGROUND: Our previous study reported a method for determining MYCN gene amplification (MNA) status using cell-free DNA in serum. We prospectively analyzed the serum MNA status using sera obtained before the initial diagnosis from patients with neuroblastoma and evaluated the utility of this method. METHODS: Eighty patients were enrolled in the study. The serum MYCN/NAGK ratio was assessed for all cases. RESULTS: Fifteen cases showed serum MNA, while 65 did not. Of the 80 total patients, tumor...
2 CitationsSource
#1Azusa Mayumi (Kyoto Prefectural University of Medicine)H-Index: 1
#2Toshihiko Imamura (Kyoto Prefectural University of Medicine)H-Index: 22
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 7 authors...
Gastrointestinal (GI) tract involvement in Langerhans cell histiocytosis (LCH) is extremely rare. Langerhans cell histiocytosis with GI tract involvement (GI-LCH) is frequently associated with multi-system disease, and usually presents with severe systemic symptoms, such as protein-losing enteropathy (PLE). Although the GI tract is not included among the organs at risk, the prognosis of GI-LCH is poor, and no effective chemotherapeutic regimen has been identified. Here, we report an infant case ...
Source
#1Yui Zen (Kyoto Prefectural University of Medicine)H-Index: 2
#2Tomohiro Chiyonobu (Kyoto Prefectural University of Medicine)H-Index: 16
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
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Abstract Aim We examined whether developmental status and behavioral problems at age five were related to the occurrence of behavioral and emotional problems in the lower grades of elementary school among non-clinical children who did not receive specialized support for developmental problems in early childhood. Methods The participants were 367 (non-clinical: 325) second- and third-grade elementary school children. The mean age at follow-up was 7.63 ( SD = 0.62). Parents completed a questionnai...
1 CitationsSource
#1Norio Nakagawa (Kyoto Prefectural University of Medicine)H-Index: 3
#2Ken Kikuchi (Kyoto Prefectural University of Medicine)H-Index: 14
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 8 authors...
Abstract Precision medicine strategies for treating rhabdomyosarcoma (RMS), a childhood malignancy, have not been developed. We examined the effect of CH5126766, a potent selective dual RAF/MEK inhibitor, on RMS cell lines. Among the eleven cell lines studied, one NRAS and two HRAS mutated cell lines were detected. CH5126766 inhibited the proliferation and growth in all of the RAS-mutated RMS cell lines, while it induced G1 cell cycle arrest in two of them. G1 cell cycle arrest was accompanied b...
3 CitationsSource
#1Yusuke Kita (Kyoto Prefectural University of Medicine)
#2Jun Mori (Kyoto Prefectural University of Medicine)H-Index: 16
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 3 authors...
Source
#1Akari Takai (Kyoto Prefectural University of Medicine)H-Index: 2
#2Tatsuji Hasegawa (Kyoto Prefectural University of Medicine)H-Index: 7
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 5 authors...
A 613 g girl was born at 23 weeks of gestation by vaginal delivery due to maternal chorioamnionitis. She developed constipation and abdominal distention on day 2, a small amount of peritoneal fluid and low blood pressure on day 4 and bloody stool on day 6. Abdominal X-ray showed a non-specific bowel gas pattern. Necrotising enterocolitis (NEC) was suspected and treated by fasting, vasopressor support …
1 CitationsSource
#1Yoshihiro Nitta (Kyoto Prefectural University of Medicine)H-Index: 2
#2Mitsuru Miyachi (Kyoto Prefectural University of Medicine)H-Index: 11
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 13 authors...
Abstract Lipoblastoma is a rare benign adipose tissue tumor that occurs mostly in infants and children. Histological diagnosis of lipoblastoma is sometimes difficult because it closely resembles other lipomatous tumors. The detection of PLAG1 gene rearrangement is useful for the diagnosis of lipoblastoma. Four PLAG1 fusion partner genes are known in lipoblastoma: HAS2 at 8q24.1, COL1A2 at 7q22, COL3A1 at 2q32, and RAB2A at 8q12. Herein, we describe a novel fusion gene in a case of lipoblastoma o...
9 CitationsSource
#1Yusuke Tsuma (Kyoto Prefectural University of Medicine)H-Index: 5
#2Jun Mori (Kyoto Prefectural University of Medicine)H-Index: 16
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 10 authors...
Abstract Erythropoietin (EPO) has been reported to exert a beneficial effect on glucose metabolism in obesity. However, the effect of EPO on lipid metabolism and non-alcoholic fatty liver disease (NAFLD) was unclear. Furthermore, the effect of long acting erythropoiesis stimulating agents (ESA) on metabolism has not been poorly understood. The objective of this study was to investigate the effect of EPO and long acting ESA on NAFLD and lipid metabolism. We administered EPO and darbepoetin alpha ...
8 CitationsSource