Hajime Hosoi
Kyoto Prefectural University of Medicine
Internal medicineEndocrinologySurgeryPathologyOncologyMolecular biologyChemistryApoptosisImmunologyChemotherapyNeuroblastomaRhabdomyosarcomaTransplantationCell cycleCancer researchCell growthMedicineCell cultureBiologyGastroenterology
230Publications
33H-index
4,497Citations
Publications 229
Newest
#1Tomoko Iehara (Kyoto Prefectural University of Medicine)H-Index: 21
#2Akihiro YonedaH-Index: 22
Last. Tatsuro Tajiri (Kyoto Prefectural University of Medicine)H-Index: 20
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BACKGROUND: Few clinical trials have been reported for patients with intermediate-risk neuroblastoma because of the scarcity of the disease and the variety of clinical and biological characteristics. A multidisciplinary treatment that consists of multidrug chemotherapy and surgery is expected to lead to a good prognosis with few complications. Therefore, a clinical trial for patients with intermediate-risk tumors was designed to establish a standard treatment that reduces complications and achie...
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#1Takashi Ishihara (Nara Medical University)H-Index: 5
#2Keiji Nogami (Nara Medical University)H-Index: 23
Last. Midori Shima (Nara Medical University)H-Index: 4
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BACKGROUND: L-asparaginase (L-Asp)-associated thromboembolisms are serious complications in pediatrics patients with acute lymphoblastic leukemia (ALL), especially at ≥10.0 years old, but the pathogenesis remains to be clarified. PROCEDURE: We conducted a multicenter, prospective study of 72 patients with ALL aged 1.0 to 15.2 years treated with either a Berlin-Frankfurt-Munster (BFM) 95-ALL oriented regimen or Japan Association of Childhood Leukemia Study ALL-02 protocol. We divided patients int...
1 CitationsSource
#1Yohei Sugimoto (Kyoto Prefectural University of Medicine)H-Index: 1
#2Masashi Nishida (Kyoto Prefectural University of Medicine)H-Index: 15
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
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#1Rika Hiramoto (Kyoto Prefectural University of Medicine)H-Index: 1
#2Mitsuru Miyachi (Kyoto Prefectural University of Medicine)H-Index: 11
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
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Abstract Introduction Cunninghamella bertholletiae although rarely causing mucormycosis, is responsible for the highest mortality among mucormycetes. The diagnosis of mucormycosis is challenged by the absence of specific biomarkers. Herein, we report a fatal case of C. bertholletiae infection and detection of its DNA in the serum by polymerase chain reaction (PCR). Presentation of case A 23-year-old male with refractory osteosarcoma was admitted with multiple lung metastases. He was on oral vori...
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#1Yuki Naito (Kyoto Prefectural University of Medicine)H-Index: 1
#2Jun Mori (Kyoto Prefectural University of Medicine)H-Index: 16
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
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: A 14-year-old girl was referred to our department because of headache and visual impairment following the resection of recurrent cardiac myxoma. Head magnetic resonance imaging (MRI) scan detected an intra- and supra-sellar tumor. Moreover, the patient showed the presence of spotty skin pigmentations on her cheeks and lower lip. Blood examination revealed hypothyrotropinemia, and ultrasonography results revealed multiple thyroid nodules. She was diagnosed with Carney complex (CNC). Her pituita...
1 CitationsSource
#1Mitsuru Miyachi (Kyoto Prefectural University of Medicine)H-Index: 11
#2Kunihiko Tsuchiya (Kyoto Prefectural University of Medicine)H-Index: 16
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
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BACKGROUND: Approximately 80% to 90% of patients with low-risk rhabdomyosarcoma can be cured. However, cured patients often face long-term complications associated with the treatment. An important factor in the treatment plan is the dose of cyclophosphamide administered because the dose can have both acute and long-term side effects. It is therefore essential to investigate whether the dose can be reduced without a negative effect on treatment outcome. The ARST0331 trial revealed that drasticall...
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#1Azusa Mayumi (Kyoto Prefectural University of Medicine)H-Index: 1
#2Toshihiro Tomii (Kyoto Prefectural University of Medicine)H-Index: 2
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
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#1Yasuhiro Kawabe (Kyoto Prefectural University of Medicine)H-Index: 4
#2Jun Mori (Kyoto Prefectural University of Medicine)H-Index: 16
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
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Angiotensin II (Ang II)/AngII type1 receptor (AT1R) axis is a key player in the pathophysiology of obesity. Angiotensin converting enzyme 2 (ACE2) counteracts Ang II/AT1R axis via converting Ang II...
21 CitationsSource
#1Masashi Nishida (Kyoto Prefectural University of Medicine)H-Index: 15
#2Shingo Kubo (Kyoto Prefectural University of Medicine)H-Index: 1
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
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OBJECTIVE: This study aims to investigate the changes in renal function and levels of urinary biomarkers before and after cardiac angiography in children with congenital heart disease (CHD). SETTING: Children with CHD are at a risk for kidney injury during contrast exposure in cardiac angiography. OUTCOME MEASURES: We measured urinary protein, albumin, N-acetyl-β-D-glucosaminidase (NAG), β2-microglobulin (BMG), and liver-type fatty acid-binding protein (L-FABP) levels, as well as serum creatinin...
2 CitationsSource
#1Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
Abstract Pediatric cancer is the leading cause of death among children. Hematopoietic tumors, which comprise approximately 40% of pediatric cancer cases, tend to be relatively self-contained in pediatric treatment centered on pediatricians, and the consolidation and standardization of clinical research are in progress. With respect to solid tumors, which comprise approximately 60% of the cases, there are many cancer types and various sites of occurrence, despite the unavailability of the absolut...
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