Alexandre Moquin
McGill University
CytotoxicityMicelleQuantum dotBiophysicsDynamic light scatteringNanoparticleField flow fractionationOrganelleNeuroscienceNanotechnologyDendritic spineEnzymeNanocarriersChemistryPolymer chemistryMaterials scienceCombinatorial chemistrySelf-assemblyBiocompatibilityTemozolomideEthylene glycolMicroparticleLipopolysaccharideDrug deliveryMicrogliaChemical engineeringPolymerViability assayBiochemistryAmphiphileBiologyCell biology
21Publications
12H-index
311Citations
Publications 21
Newest
#1Parinaz Sabourian (McGill University)H-Index: 3
#2Jeff Ji (McGill University)H-Index: 6
Last. Ashok K. Kakkar (McGill University)H-Index: 43
view all 8 authors...
Easily assembled and biocompatible chitosan/hyaluronic acid nanoparticles with multiple stimuli-responsive ability are ideally suited for efficient delivery of therapeutic agents under specific endogenous triggers. We report a simple and versatile strategy to formulate oxidative stress and pH-responsive chitosan/hyaluronic acid nanocarriers with high encapsulation efficiencies of small drug molecules and nerve growth factor protein. This is achieved through invoking the dual role of a thioketal-...
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#1Alexandre Moquin (McGill University)H-Index: 12
#2Jessica Sturn (McGill University)H-Index: 1
Last. Ashok K. Kakkar (McGill University)H-Index: 43
view all 8 authors...
Amphiphilic architectural polymers of tunable compositions self-assemble into soft nanoparticles of varied stability that is dependent on the number of poly(ethylene glycol) tails. Cryo-electron microscopy- and freeze-fracture-technique-based evaluations of their internal structure display morphologies unlike those of conventional block-copolymer-based micelles, with a uniform and homogeneous composition that strongly influences drug-specific encapsulation and release characteristics. The subera...
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#1Alexandre Moquin (McGill University)H-Index: 12
#2Ramez Hanna (McGill University)H-Index: 2
Last. Ashok K. Kakkar (McGill University)H-Index: 43
view all 8 authors...
Polyethylene glycol grafted pyrrole-based conjugated polymers are synthesized through a one-pot multicomponent methodology, the self-assemblies of which enable nanoparticle size-selective encapsulation of drug molecules and their sustained release. Efficient loading of curcumin through drug–nanoparticle core interactions is probed using FRET, and the inherently fluorescent nature of polypyrrole could be used to detect these nanocarriers intracellularly.
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#1Jeff Ji (McGill University)H-Index: 6
#2Alexandre Moquin (McGill University)H-Index: 12
Last. Dusica Maysinger (McGill University)H-Index: 63
view all 8 authors...
AbstractGold nanoparticles (AuNP) have unique physicochemical properties and have been used as delivery vehicles, contrast agents, and therapeutic compounds. Although the effects of AuNPs on periph...
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#1Yiu Chung Tse (Douglas Mental Health University Institute)H-Index: 12
#2Joëlle Lopez (Douglas Mental Health University Institute)H-Index: 1
Last. Tak Pan Wong (McGill University)H-Index: 32
view all 6 authors...
N-methyl-d-aspartate receptors (NMDARs) have been highly implicated in the pathogenesis and treatment of depression. While NMDARs can be found inside and outside glutamate synapses, it remains unclear if NMDARs at synaptic (sNMDAR) and extrasynaptic locations (exNMDAR) play different roles in the formation of depression-related behaviors. Using chronic social defeat stress (CSDS), an animal model for anxiety- and depression-related behaviors, we found that mice susceptible to CSDS exhibited low ...
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#1Alexandre Moquin (McGill University)H-Index: 12
#2Jeff Ji (McGill University)H-Index: 6
Last. Dusica Maysinger (McGill University)H-Index: 63
view all 5 authors...
Polymersomes are attractive nanocarriers for hydrophilic and lipophilic drugs; they are more stable than liposomes, tunable, and relatively easy to prepare. The copolymer composition and molar mass are critical features that determine the physicochemical properties of the polymersomes including the rate of drug release. We used the triblock-copolymer, poly(2-methyl-2-oxazoline)-block-poly-(dimethysiloxane)-block-poly(2-methyl-2-oxazoline) (PMOXA–PDMS–PMOXA), to form amphipathic polymersomes capa...
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#1Dusica Maysinger (McGill University)H-Index: 63
#2Jeff Ji (McGill University)H-Index: 6
Last. Gerhard Multhaup (McGill University)H-Index: 17
view all 15 authors...
Dendritic polyglycerols (dPG), particularly dendritic polyglycerol sulfates (dPGS), have been intensively studied due to their intrinsic anti-inflammatory activity. As related to brain pathologies involving neuroinflammation, the current study examined if dPG and dPGS can (i) regulate neuroglial activation, and (ii) normalize the morphology and function of excitatory postsynaptic dendritic spines adversely affected by the neurotoxic 42 amino acid amyloid-β (Aβ42) peptide of Alzheimer disease (AD...
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#1Dusica Maysinger (McGill University)H-Index: 63
#2Alexandre Moquin (McGill University)H-Index: 12
Last. Ursula Stochaj (McGill University)H-Index: 24
view all 5 authors...
The physicochemical properties and cytotoxicity of diverse gold nanoparticle (AuNP) morphologies with smooth surfaces have been examined extensively. Much less is known about AuNPs with irregular surfaces. This study focuses on the effects of gold nanourchins in glioblastoma cells. With limited success of monotherapies for glioblastoma, multimodal treatment has become the preferred regimen. One possible example for such future therapeutic applications is the combination of AuNPs with the natural...
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#1Jason Choi (McGill University)H-Index: 2
#2Alexandre Moquin (McGill University)H-Index: 12
Last. Ashok K. Kakkar (McGill University)H-Index: 43
view all 6 authors...
New therapeutics for glioblastoma multiforme and our ability to deliver them using efficient nanocarriers constitute topical areas of research. We report a comparative study of temozolomide and quercetin in the treatment of glioblastoma (GBM) in three-dimensions, and their incorporation into micelles obtained from synthetically articulated architectural copolymers, and a commercially available linear polymer poly(ethylene glycol)-poly(lactic-co-glycolic acid) (PEG–PLGA). A versatile synthetic me...
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#1Abdolali Amiri (McGill University)H-Index: 2
#2Phuong Uyen Le (Montreal Neurological Institute and Hospital)H-Index: 8
Last. Dusica Maysinger (McGill University)H-Index: 63
view all 8 authors...
Abstract Carbonic anhydrase IX (CA IX) is a transmembrane enzyme upregulated in several types of tumors including glioblastoma multiforme (GBM). GBM is among the most aggressive tumors among gliomas. Temozolomide (TMZ) therapy combined with surgical or radiation approaches is the standard treatment but not effective in long term. In this study we tested the treatment with acetazolamide (ATZ), an inhibitor of CA IX, alone or combined with TMZ. The experiments were performed in 2D and 3D cultures ...
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